Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer
Open accessAbstract
Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that PTT combined with chemotherapy can trigger potent anti-tumor immunity against disseminated tumors. Specifically, we have developed polydopamine-coated spiky gold nanoparticles as a new photothermal agent with extensive photothermal stability and efficiency. Strikingly, a single round of PTT combined with a sub-therapeutic dose of doxorubicin can elicit robust anti-tumor immune responses and eliminate local as well as untreated, distant tumors in >85% of animals bearing CT26 colon carcinoma. We also demonstrate their therapeutic efficacy against TC-1 submucosa-lung metastasis, a highly aggressive model for advanced head and neck squamous cell carcinoma (HNSCC). Our study sheds new light on a previously unrecognized, immunological facet of chemo-photothermal therapy and may lead to new therapeutic strategies against advanced cancer.
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BLI is used to assess nanodrug efficiency based on endogenic luminescence of tumors to confirm NPs diagnostics or theranostic prospects and to integrate with other imaging modalities.
“BLI is used to assess nanodrug efficiency based on the endogenic luminescence of tumors to confirm NPs diagnostics or theranostic prospects and to integrate with other imaging modalities [19,134,135,136].”
From Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis (2023) · cites this paper as [136]
The Results section (“Chemo-PTT against advanced head and neck cancer”) uses bioluminescence imaging to assess the efficacy of nanoparticle-based treatment, reporting reduced tumor signals. But the signal came from tumors made with firefly luciferase-expressing cells, not endogenous tumor luminescence. The paper does not establish nanoparticle diagnostic prospects or integration with other imaging modalities. (LLM, conf=0.88)
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- Authors
- Nam, J., Son, S., Ochyl, L. J., Kuai, R., Schwendeman, A., & Moon, J. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Moon, James J.
- Venue
- Nature Communications
- Published
- 2018-03-14
- Volume
- 9
- Issue
- 1
- Pages
- 1074-1074
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5852008
- OpenAlex
- W2791998350
- Cited by
- 808
- References
- 59
- Citations by year
- 2026: 43 · 2025: 68 · 2024: 81 · 2023: 86 · 2022: 120 · 2021: 152 · 2020: 127 · 2019: 98 · 2018: 32
- FWCI
- 40.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Science Foundation (1553831, R01EB022563, CAREER, R01CA210273, HHSN272201300006C)
- U.S. Department of Defense (W81XWH1610369, W81XWH)
- American Heart Association (15PRE25090050)
- Melanoma Research Alliance (348774)
- American Foundation for Pharmaceutical Education
- Johns Hopkins University
- Emerald Foundation
- National Institutes of Health (HHSN272201300006C), W81XWH, 1553831)
- National Cancer Institute (R01CA210273)
- National Institute of Allergy and Infectious Diseases (HHSN-272201300006C)
- National Institute of Biomedical Imaging and Bioengineering (R01EB022563)
- Congressionally Directed Medical Research Programs (W81XWH-16-1-0369)
- DOD Peer Reviewed Cancer Research Program (W81XWH-16)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- photothermal therapy, chemo-photothermal therapy, antitumor immunity, metastatic cancer, doxorubicin, CT26 cells, lung metastasis, head and neck squamous cell carcinoma, photothermal stability
- MeSH terms
- Animals, Combined Modality Therapy, Doxorubicin, Drug Therapy, Combination, Humans, Neoplasm Metastasis, Photochemotherapy, Phototherapy, Cell Line, Tumor
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