Black Mn-containing layered double hydroxide coated magnesium alloy for osteosarcoma therapy, bacteria killing, and bone regeneration
Open accessAbstract
Osteosarcoma (OS) tissue resection with distinctive bactericidal activity, followed by regeneration of bone defects, is a highly demanded clinical treatment. Biodegradable Mg-based implants with desirable osteopromotive and superior mechanical properties to polymers and ceramics are promising new platforms for treating bone-related diseases. Integration of biodegradation control, osteosarcoma destruction, anti-bacteria, and bone defect regeneration abilities on Mg-based implants by applying biosafe and facile strategy is a promising and challenging topic. Here, a black Mn-containing layered double hydroxide (LDH) nanosheet-modified Mg-based implants was developed. Benefiting from the distinctive capabilities of the constructed black LDH film, including near-infrared optical absorption and reactive oxygen species (ROS) generation in a tumor-specific microenvironment, the tumor cells and tissue could be effectively eliminated. Concomitant bacteria could be killed by localized hyperthermia. Furthermore, the enhanced corrosion resistance and synergistic biofunctions of Mn and Mg ions of the constructed black LDH-modified Mg implants significantly facilitated cell adhesion, spreading and proliferation and osteogenic differentiation in vitro, and accelerated bone regeneration in vivo. This work offers a new platform and feasible strategy for OS therapeutics and bone defect regeneration, which broadens the biomedical application of Mg-based alloys.
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Uncontrolled Mg corrosion causes harmful accumulation of degradation by-products (e.g., H2 and Mg(OH)2), compromising peri-implant biocompatibility and biointegration and limiting clinical applicability.
“Nonetheless, uncontrolled Mg corrosion incurs the harmful accumulation of degradation by-products (e.g., H2 and Mg(OH)2), which compromises peri-implant biocompatibility and biointegration, thereby limiting the clinical applicability [23,45].”
From Nanocatalytic magnesium osteoimplants with biodegradable self-adaptive interfaces for therapeutic repair of infected bone defects (2026) · cites this paper as [45]
The Introduction says Mg corrosion can cause excess hydrogen, Mg ions and alkalinity near an implant, resulting in poor biocompatibility and restricting orthopedic use. The In vitro biocompatibility section also links corrosion-derived hydrogen and excessive Mg²⁺ and OH⁻ to inhibited surrounding cell activity. Our copy does not identify Mg(OH)₂ accumulation specifically or directly establish impaired biointegration as a consequence. (LLM, conf=0.86)
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- Authors
- Zhang, D., Cheng, S., Tan, J., Xie, J., Zhang, Y., Chen, S., Du, H., Qian, S., Qiao, Y., Peng, F., & Liu, X.
- Affiliations
- Chinese Academy of Sciences (CN)
- Guangdong Academy of Medical Sciences (CN)
- Corresponding author
- Zhang, Yu
- Peng, Feng
- Liu, Xuanyong
- ORCID
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2022-11
- Volume
- 17
- Pages
- 394-405
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- PMC
- PMC8965036
- OpenAlex
- W4210440120
- Cited by
- 79
- References
- 58
- Citations by year
- 2026: 6 · 2025: 19 · 2024: 18 · 2023: 23 · 2022: 13
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Bioactive Materials (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- osteosarcoma, magnesium alloy implants, layered double hydroxides, near-infrared photothermal therapy, reactive oxygen species, local hyperthermia, antibacterial activity, bone regeneration, bone defect repair, osteogenic differentiation, corrosion resistance, biodegradable implants
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