Cited by 49Neuroscience and Neural EngineeringTissue Engineering and Regenerative MedicineMicrobial Fuel Cells and Bioremediation

Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities

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Wang, Donghui, Tan, Ji, Zhu, Hongqin, Mei, Yongfeng, Liu, Xuanyong·2021·Advanced Science

Abstract

Transmembrane charge (ion/electron) transfer is essential for maintaining cellular homeostasis and is involved in many biological processes, from protein synthesis to embryonic development in organisms. Designing implant devices that can detect or regulate cellular transmembrane charge transfer is expected to sense and modulate the behaviors of host cells and tissues. Thus, charge transfer can be regarded as a bridge connecting living systems and human‐made implantable devices. This review describes the mode and mechanism of charge transfer between organisms and nonliving materials, and summarizes the strategies to endow implants with charge‐transfer regulating or monitoring abilities. Furthermore, three major charge‐transfer controlling systems, including wired, self‐activated, and stimuli‐responsive biomedical implants, as well as the design principles and pivotal materials are systematically elaborated. The clinical challenges and the prospects for future development of these implant devices are also discussed.

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Crossref · 10.1002/advs.202004393

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Authors
Wang, D., Tan, J., Zhu, H., Mei, Y., & Liu, X.
Affiliations
  • Hebei University of Technology (CN)
  • Chinese Academy of Sciences (CN)
  • Fudan University (CN)
Corresponding author
  • Mei, Yongfeng
  • Liu, Xuanyong
Venue
Advanced Science
Publisher
Wiley
Published
2021-06-24
Volume
8
Issue
16
Pages
e2004393-e2004393
ISSN
2198-3844 (ISSN-L)
OpenAlex
W3176994442
Cited by
49
References
422
Citations by year
2026: 6 · 2025: 14 · 2024: 10 · 2023: 7 · 2022: 10 · 2021: 2
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Advanced Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Key Research and Development Program of China (2017YFB0702600, 2017YFB0702602)
  • National Natural Science Foundation of China (51831011, 51901239, 61975035, 51961145108)
  • Science and Technology Commission of Shanghai Municipality (19JC1415500, 18YF1426900)
  • Program of Shanghai Academic Research Leader (19XD1400600)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
Keywords
biomedical implants, implant materials, cellular homeostasis
MeSH terms
Electron Transport, Humans, Biosensing Techniques, Prostheses and Implants

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