RBM4: A multifunctional RNA-binding protein

The multifunctional nucleolus

Boisvert, F., van Koningsbruggen, S., Navascués, J., & Lamond, A. (2007) · Nature reviews. Molecular cell biology · doi:10.1038/nrm2184 · Cited by 1,581 · see citing works

RNA regulons: coordination of post-transcriptional events

Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321 · see citing works

A tumor suppressor and oncogene: the WT1 story

Yang, L., Han, Y., Saiz, F. S., & Minden, M. D. (2007) · Leukemia · doi:10.1038/sj.leu.2404624 · Cited by 472 · see citing works

Proteomic and functional analysis of Argonaute‐containing mRNA–protein complexes in human cells

Höck, J., Weinmann, L., Ender, C., Rüdel, S., Kremmer, E., Raabe, M., Urlaub, H., & Meister, G. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401088 · Cited by 332 · see citing works

Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesisPreprint

Rao, M. K., Pham, J. W., Imam, J. S., MacLean, J. A., Murali, D., Furuta, Y., Sinha‐Hikim, A. P., & Wilkinson, M. (2006) · Genes & Development · doi:10.1101/gad1367806 · Cited by 115 · see citing works

A novel splicing regulator shares a nuclear import pathway with SR proteins

Lai, M., Kuo, H., Chang, W., & Tarn, W. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg126 · Cited by 109 · see citing works

A Molecular Rhythm Mediating Circadian Clock Output in Drosophila

McNeil, G. P., Zhang, X., Genova, G., & Jackson, F. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80457-2 · Cited by 107 · see citing works

Cell stress modulates the function of splicing regulatory protein RBM4 in translation control

Lin, J.-C., Hsu, M., & Tarn, W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611015104 · Cited by 100 · see citing works

LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1

Kojima, S., Matsumoto, K., Hirose, M., Shimada, M., Nagano, M., Shigeyoshi, Y., Hoshino, S.-I., Ui‐Tei, K., Saigo, K., Green, C. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607567104 · Cited by 93 · see citing works

The post-transcriptional roles of WT1, a multifunctional zinc-finger protein

Morrison, A. A., Viney, R. L., & Ladomery, M. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.10.002 · Cited by 93 · see citing works

Exon Selection in α-Tropomyosin mRNA Is Regulated by the Antagonistic Action of RBM4 and PTB

Lin, J.-C., & Tarn, W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10111-10121.2005 · Cited by 74 · see citing works

Identification of Interaction Partners and Substrates of the Cyclin A1-CDK2 Complex

Diederichs, S., Bäumer, N., Ji, P., Metzelder, S., Idos, G., Cauvet, T., Wang, W., Möller, M., Pierschalski, S., Gromoll, J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401708200 · Cited by 73 · see citing works

RBM4 Interacts with an Intronic Element and Stimulates Tau Exon 10 Inclusion

Kar, A. N., Havlioglu, N., Tarn, W., & Wu, J. Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603971200 · Cited by 59 · see citing works

SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations

Gao, L., Wang, J., Wang, Y., & Andreadis, A. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.10.004 · Cited by 57 · see citing works

WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo

Markus, M. A., Heinrich, B., Raitskin, O., Adams, D. J., Mangs, H., Goy, C., Ladomery, M., Sperling, R., Stamm, S., & Morris, B. J. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.07.008 · Cited by 51 · see citing works

Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain

Bernert, G., Fountoulakis, M., & Lübec, G. (2002) · PROTEOMICS · doi:10.1002/1615-9861(200212)2:12 · Cited by 42 · see citing works

The LARK RNA-Binding Protein Selectively Regulates the Circadian Eclosion Rhythm by Controlling E74 Protein Expression

Huang, Y., Genova, G., Roberts, M. A., & Jackson, F. R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001107 · Cited by 38 · see citing works

Genetic Analysis of Functional Domains Within the Drosophila LARK RNA-Binding Protein

McNeil, G. P., Schroeder, A. J., Roberts, M. A., & Jackson, F. R. (2001) · Genetics · doi:10.1093/genetics/159.1.229 · Cited by 26 · see citing works

Lark Is the Splicing Factor RBM4 and Exhibits Unique Subnuclear Localization Properties

Markus, M. A., & Morris, B. J. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.457 · Cited by 20 · see citing works

The inturned protein of Drosophila melanogaster is a cytoplasmic protein located at the cell periphery in wing cells

Yun, U. J., Kim, S. Y., Liu, J., Adler, P. N., Bae, E., Kim, J., & Park, W. J. (1999) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1999)25:4 · Cited by 16 · see citing works

Gene Expression Profiling in Apoptotic K562 Cells Treated by Homoharringtonine

Jin, W., Wu, J., Zhuang, Z., Li, J., Fei, F., Di, G., Chen, Y., Yao, M., & Shao, Z. (2007) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2007.00364.x · Cited by 7 · see citing works

A compendium of RNA-binding motifs for decoding gene regulation

Ray, D., Kazan, H., Cook, K. B., Weirauch, M. T., Najafabadi, H. S., Li, X., Gueroussov, S., Albu, M., Zheng, H., Yang, A., et al. (2013) · Nature · doi:10.1038/nature12311 · Cited by 1,480 · see citing works

MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-α during TLR4-induced gene reprogramming

Gazzar, M. E., Church, A., Liu, T., & McCall, C. E. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0211074 · Cited by 129 · see citing works

The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA

Nowak, U. M., Matthews, A. J., Zheng, S., & Chaudhuri, J. (2010) · Nature Immunology · doi:10.1038/ni.1977 · Cited by 121 · see citing works

RNA Helicase p68 (DDX5) Regulates tau Exon 10 Splicing by Modulating a Stem-Loop Structure at the 5′ Splice Site

Kar, A. N., Fushimi, K., Zhou, X., Ray, P., Chen, S., Chen, X., Liu, Z., Chen, S., & Wu, J. Y. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01149-10 · Cited by 120 · see citing works

Proteomics Analysis of the Nucleolus in Adenovirus-infected Cells

Lam, Y. W., Evans, V. C., Heesom, K. J., Lamond, A. I., & Matthews, D. A. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900338-mcp200 · Cited by 119 · see citing works

High-throughput characterization of protein-RNA interactions

Cook, K. B., Hughes, T., & Morris, Q. (2014) · Briefings in Functional Genomics · doi:10.1093/bfgp/elu047 · Cited by 82 · see citing works

Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing

Rambout, X., Dequiedt, F., & Maquat, L. E. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00470 · Cited by 83 · see citing works

Nuclear Aurora kinase A switches m6A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

Li, S., Qi, Y., Yu, J., Hao, Y., He, B., Zhang, M., Dai, Z., Jiang, T., Li, S., Huang, F., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00905-3 · Cited by 76 · see citing works

The distinct roles of zinc finger CCHC-type (ZCCHC) superfamily proteins in the regulation of RNA metabolism

Wang, Y., Yu, Y., Pang, Y., Yu, H., Zhang, W., Zhao, X., & Yu, J. (2021) · RNA Biology · doi:10.1080/15476286.2021.1909320 · Cited by 55 · see citing works

Genome-wide analysis of CCHC-type zinc finger (ZCCHC) proteins in yeast, Arabidopsis, and humans

Aceituno-Valenzuela, U., Micol‐Ponce, R., & Ponce, M. R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03518-7 · Cited by 54 · see citing works

A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

Gowen, B. G., Chim, B., Marceau, C. D., Greene, T. T., Burr, P., Gonzalez, J. R., Hesser, C. R., Dietzen, P. A., Russell, T. A., Iannello, A., et al. (2015) · eLife · doi:10.7554/elife.08474 · Cited by 52 · see citing works

Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs

Hsu, J. C.-C., Reid, D. W., Hoffman, A. M., Sarkar, D., & Nicchitta, C. V. (2018) · RNA · doi:10.1261/rna.063313.117 · Cited by 51 · see citing works

RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression

Han, H., Lin, T., Wang, Z., Song, J., Fang, Z., Zhang, J., You, X., Du, Y., Ye, J., & Zhou, G. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106593 · Cited by 46 · see citing works

Lewis K. Dahl Memorial Lecture

Diz, D. I. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.108985 · Cited by 38 · see citing works

RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function

Zhang, P., Wu, W., Ma, C., Du, C., Huang, Y., Xu, H., Li, C., Cheng, X., Hao, R., & Xu, Y. (2022) · Cells · doi:10.3390/cells11152357 · Cited by 35 · see citing works

Circadian mRNA expression: insights from modeling and transcriptomics

Lück, S., & Westermark, P. O. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2072-2 · Cited by 32 · see citing works

rbm47, a novel RNA binding protein, regulates zebrafish head development

Guan, R., El‐Rass, S., Spillane, D. R., Lam, S., Wang, Y., Wu, J., Chen, Z., Wang, A., Jia, Z., Keating, A., et al. (2013) · Developmental Dynamics · doi:10.1002/dvdy.24039 · Cited by 32 · see citing works

Modulation of alternative splicing during early infection of human primary B lymphocytes with Epstein-Barr virus (EBV): a novel function for the viral EBNA-LP protein

Manet, É., Polvèche, H., Mure, F., Mrozek-Górska, P., Roisné-Hamelin, F., Hammerschmidt, W., Auboeuf, D., & Gruffat, H. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab787 · Cited by 25 · see citing works

Prognostic value of decreased expression of RBM4 in human gastric cancer

Yong, H., Zhu, H., Zhang, S., Zhao, W., Wang, W., Chen, C., Ding, G., Zhu, L., Zhu, Z., Liu, H., et al. (2016) · Scientific Reports · doi:10.1038/srep28222 · Cited by 25 · see citing works

Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction

Lu, L.-F., Zhang, C., Zhou, X.-Y., Li, Z.-C., Chen, D., Zhou, Y., Zhou, F. J., Zhang, Y., & Li, S. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901387 · Cited by 24 · see citing works

Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants

Moreira‐Filho, C. A., Bando, S. Y., Bertonha, F. B., Silva, F. N., Costa, L. D. F., Ferreira, L., Furlanetto, G., Chaccur, P., Zerbini, M. C. N., & Carneiro-Sampaio, M. M. S. (2016) · Oncotarget · doi:10.18632/oncotarget.7120 · Cited by 23 · see citing works

G-Quadruplex Regulation of VEGFA mRNA Translation by RBM4

Niu, K., Zhang, X., Song, Q., & Feng, Q. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020743 · Cited by 19 · see citing works

The quantitative impact of 3′UTRs on gene expression

West, J. D., Smith, H. J., Vu, L. T., Fogarty, E. A., Matreyek, K. A., Fowler, D. M., & Grimson, A. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf568 · Cited by 17 · see citing works

RBM4 modulates the proliferation and expression of inflammatory factors via the alternative splicing of regulatory factors in HeLa cells

Wang, W.-Y., Quan, W., Yang, F., Wei, Y., Chen, J., Yu, H., Xie, J., Zhang, Y., & Li, Z. (2019) · Molecular Genetics and Genomics · doi:10.1007/s00438-019-01606-3 · Cited by 14 · see citing works

Phylogenetic and Molecular Characterization of the Splicing Factor RBM4

Lu, C., Chen, T.-H., Wu, J.-R., Chen, H.-H., Yu, H.-Y., & Tarn, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059092 · Cited by 12 · see citing works

CircRNA GRAMD4 induces NBR1 expression to promote autophagy and immune escape in renal cell carcinoma

Zhou, M., Chen, M., Zheng, Z., Li, Q., Liao, L., Wang, Y., Xu, Y., Shu, G., Luo, J., Yang, T., et al. (2025) · Autophagy · doi:10.1080/15548627.2025.2503560 · Cited by 11 · see citing works

The health status alters the pituitary function and reproduction of mice in aCxcr2-dependent manner

Timaxian, C., Raymond‐Letron, I., Bouclier, C., Gulliver, L., Corre, L. L., Chébli, K., Guillou, A., Mollard, P., Balabanian, K., & Lazennec, G. (2020) · Life Science Alliance · doi:10.26508/lsa.201900599 · Cited by 11 · see citing works

The zinc-ribbon domain of Helicobacter pylori HP0958: requirement for RpoN accumulation and possible roles of homologs in other bacteria

Pereira, L. E., Tsang, J., Mrázek, J., & Hoover, T. R. (2011) · Microbial Informatics and Experimentation · doi:10.1186/2042-5783-1-8 · Cited by 9 · see citing works

Long-read subcellular fractionation and sequencing reveals the translational fate of full-length mRNA isoforms during neuronal differentiationPreprint

Ritter, A. J., Draper, J. M., Vollmers, C., & Sanford, J. R. (2024) · Genome Research · doi:10.1101/gr.279170.124 · Cited by 9 · see citing works

RNA binding motif 4 inhibits the replication of ebolavirus by directly targeting 3′-leader region of genomic RNA

Fan, L., Wang, Y., Huang, H., Wang, Z., Liang, C., Yang, X., Ye, P., Lin, J., Shi, W., Zhou, Y., et al. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2023.2300762 · Cited by 7 · see citing works

The N6‐methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4

Xu, M., Li, B., Huang, J., Jia, R., & Guo, J. (2023) · International Endodontic Journal · doi:10.1111/iej.13975 · Cited by 6 · see citing works

Signaling pathways involved in the expression of SZNF and the target genes binding with SZNF related to cyadox

Cui, L., Xing, D., Huang, D., Li, D., Lu, Q., Wang, X., Wang, Y., Huang, L., Cheng, G., Hao, H., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.141 · Cited by 6 · see citing works

Portrait of Transcriptional Expression Profiles Displayed by Different Glioblastoma Cell Lines

Godoy, P. R. D. V., Stephano, S., Daniele, A., Flavia, S., Ana, P., Nicolucci, P., Eduardo, A., Passos, G. A. S., & Elza, T. (2011) · InTech eBooks · doi:10.5772/22322 · Cited by 4 · see citing works

The role and mechanism of BmsPLA2-1-1 in the IMD pathway in silkworm, Bomybx mori

Wei, H., Li, T., Xiong, B., Shen, L., & Chen, P. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137297 · Cited by 4 · see citing works

Renin, Genes, and Beyond

Morris, B. J. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.166967 · Cited by 4 · see citing works

Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1

Sun, W., Fang, X., Zhang, H., Lu, Y., Wang, P., Li, J., & Li, M. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024103 · Cited by 3 · see citing works

A Comprehensive Prognostic and Immune Infiltration Analysis of RBM4 in Pan-Cancer

Ding, J.-J., Wu, J., Bian, H.-L., Zong, Y., Lü, B., & Li, N. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2902089 · Cited by 3 · see citing works

Thymus Gene Coexpression Networks: A Comparative Study in Children with and Without Down Syndrome

Moreira‐Filho, C. A., Bando, S. Y., Bertonha, F. B., Silva, F. N., Costa, L. D. F., & Carneiro-Sampaio, M. M. S. (2014) · Springer eBooks · doi:10.1007/978-3-319-11985-4_7 · Cited by 3 · see citing works

Crystal structure of theMSMEG_4306gene product fromMycobacterium smegmatis

Kumar, A. M., & Karthikeyan, S. (2018) · Acta Crystallographica Section F Structural Biology Communications · doi:10.1107/s2053230x18002236 · Cited by 2 · see citing works

Identification of a naturally processed HLA ‐Cw7‐binding peptide that cross‐reacts with HLA‐A24 ‐restricted ovarian cancer‐specific CTLs

Yamada, E., Demachi‐Okamura, A., Kondo, S., Akatsuka, Y., Suzuki, S., Shibata, K., Kikkawa, F., & Kuzushima, K. (2015) · Tissue Antigens · doi:10.1111/tan.12607 · Cited by 2 · see citing works

Chemoproteomic Profiling of 8-Oxoguanosine-Sensitive RNA–Protein Interactions

Villers, J., Smith, E. M., DeLiberto, A. N., Arguello, A. E., Nyaanga, J., & Kleiner, R. E. (2023) · Biochemistry · doi:10.1021/acs.biochem.3c00461 · Cited by 2 · see citing works

Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction

Shen, C.-L., Tsai, Y.-Y., & Tarn, W. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1608185 · Cited by 1 · see citing works

Novel role of NR1D1 and SLC7A5 in gestational diabetes mellitus: regulation of polyamine metabolism

Wang, Z., Fang, G., Yao, Y., & Wang, J. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01691-9 · Cited by 1 · see citing works

INVESTIGATIONS INTO THE EFFECTS OF ALTERED TITIN ISOFORM EXPRESSION IN STRIATED MUSCLE

Pleitner, J. M. (2013) · Cited by 1 · see citing works

Efeitos do Silenciamento de E2F1 e HEB, Fatores de Transcrição Preditos In Silico, em Células de Glioblastoma Irradiadas com Raios Gama.

Godoy, P. R. D. V. (2013) · doi:10.11606/t.17.2013.tde-13062013-094602

A mechanism for co-transcriptional recruitment of mRNA localization factor on nascent mRNAs in budding yeast

Shen, Z. F. (2010) · doi:10.71781/26303

Regulation and Genetic Manipulation of Ligands for the Immunoreceptor NKG2D

Gowen, B. G. (2015) · eScholarship (California Digital Library)

The translation landscape of ovarian clear cell carcinoma indicates that RBM4 plays a pro-oncogenic role in tumor progression

Chen, Y., Lu, D., Xing, Y., He, J., Zhang, S., Wang, X., Li, M., Wang, Y., Gao, Y., Wang, A., et al. (2026) · Oncogene · doi:10.1038/s41388-026-03840-7

RBM4 Promotes Nasopharyngeal Carcinoma Growth and Metastasis by Stabilizing HOXB13 mRNA

Chen, Z., Liang, D., Liu, Z., Ren, Y., Wang, Z., Wan, J., Tang, Y., & Zhou, Y. (2026) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-026-02139-4

The RNA Recognition Motif and Messenger RNA

Hall, K. B. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4954-6_6

The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum

Pfuhl, T., Mamiani, A., Dürr, M., Welter, S., Stieber, J., Ankara, J., Liss, M. A., Dobner, T., Schmitt, A., Falkai, P., et al. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.017 · Cited by 6 · see citing works

Lark Is the Splicing Factor RBM4 and Exhibits Unique Subnuclear Localization Properties

Markus, M. A., & Morris, B. J. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.457 · Cited by 20 · see citing works

RBM4 modulates the proliferation and expression of inflammatory factors via the alternative splicing of regulatory factors in HeLa cells

Wang, W.-Y., Quan, W., Yang, F., Wei, Y., Chen, J., Yu, H., Xie, J., Zhang, Y., & Li, Z. (2019) · Molecular Genetics and Genomics · doi:10.1007/s00438-019-01606-3 · Cited by 14 · see citing works

RBM4-Regulated Alternative Splicing Suppresses Tumorigenesis

(2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2014-198 · Cited by 10 · see citing works

RNA binding motif 47 (RBM47): emerging roles in vertebrate development, RNA editing and cancer

Shivalingappa, P. K. M., Sharma, V., Shiras, A., & Bapat, S. A. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04256-5 · Cited by 52 · see citing works