Clastic cells: Mineralized tissue resorption in health and disease
Abstract
Clastic cells are responsible for mineralized tissue resorption. Bone resorbing cells are called osteoclasts; however, they are able to resorb mineralized dental tissues or calcified cartilage and then they are called odontoclasts and chondroclasts, respectively. They derive from mononuclear precursors of the monocyte-macrophage lineage from hemopoietic tissue, reach target mineralized tissues and degrade them under many different physiologic or pathologic stimuli. Clastic cells play a key role in calcium homeostasis, and participate in skeletal growth, tooth movement, and other physiological and pathological events. They interact tightly with forming cells in bone and dental hard tissues; their unbalance may result in disturbed resorptive activity thus, causing local or systemic diseases.
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During bone remodeling osteoclasts polarize into four membrane domains: the sealing zone, ruffled border, basolateral domain, and functional secretory domain.
“During bone remodeling osteoclasts polarize; then, four types of osteoclast membrane domains can be observed: the sealing zone and ruffled border that are in contact with the bone matrix (Figures 4(b) and 4(d)), as well as the basolateral and functional secretory domains, which are not in contact with the bone matrix [94, 95].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [95]
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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works
- Authors
- Arana-Chavez, V. E., & Bradaschia-Correa, V.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Arana-Chavez, Victor E.
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 41
- Issue
- 3
- Pages
- 446-450
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W2118413209
- Cited by
- 69
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 8 · 2013: 5 · 2012: 3
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Alkaline Phosphatase Research Studies
- Keywords
- osteoclasts, odontoclasts, chondroclasts, bone resorption, calcium homeostasis, tooth movement, skeletal development, monocyte/macrophage lineage, dental hard tissue, calcified cartilage, bone disease
- MeSH terms
- Animals, Bone Diseases, Bone Regeneration, Bone Resorption, Calcification, Physiologic, Calcium, Cell Differentiation, Humans, Macrophages, Odontogenesis, Osteoclasts, Osteogenesis, Tooth, Cell Lineage
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