Mechanistic insight into osteoclast differentiation in osteoimmunology
Abstract
Recently a close relationship between the immune and skeletal systems or the interdisciplinary field called osteoimmunology has attracted much attention due to the observations that bone destruction is caused by an abnormal activation of the immune system in rheumatoid arthritis, and that mice lacking immunomodulatory molecules often exhibit an unexpected bone phenotype. Osteoclasts are cells of monocyte/macrophage origin that degrade the bone matrix. They are among the key players in the control of bone metabolism in health and disease. Receptor activator of NF-kappaB ligand (RANKL), a tumor necrosis factor (TNF) family cytokine, induces the differentiation of osteoclasts in the presence of macrophage-colony stimulating factor. RANKL activates TRAF6, c-Fos, and calcium signaling pathways, all of which are indispensable for the induction and activation of nuclear factor of activated T cells (NFAT) c1, the master transcription factor for osteoclastogenesis. The autoamplification of NFATc1 gene results in the efficient induction of osteoclast-specific genes. An AP-1 transcription factor complex containing c-Fos plays a crucial role in these processes, although results in conditional knockout mice show that Jun family members have a redundant role. The immunoreceptor tyrosine-based activation motif (ITAM) is an important signaling component for a number of receptors in the immune system including T-cell, B-cell, NK-cell, and Fc receptors, but its contribution to the skeletal sys…
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The calcineurin pathway is a key costimulatory pathway of NFATc1 and an important signaling component of a number of immune cell receptors.
“This activates cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) and the calcineurin pathway [21,24,25,27], a key costimulatory pathway of NFATc1 [21,23] and an important signaling component of a number of immune cell receptors [28] (Figure 4 and Figure 5).”
From Osteoclasts and Microgravity (2020) · cites this paper as [28]
Cites
Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
Almilaji, A., Szteyn, K., Fein, E., Pakladok, T., Muñoz, C., Elvira, B., Towhid, S. T., Alesutan, I., Shumilina, E. V., Bock, C. –., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350083 · Cited by 8,675 · see citing works
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · cited 1× · see citing works
“Based on the fact that the addition of RANKL and M-CSF can induce osteoclast differentiation in culture, it has been generally believed that RANKL and M-CSF are not only essential but also sufficient for osteoclastogenesis [24].”
BackgroundThe versatility and universality of calcium signalling
Berridge, M. J., Lipp, P., & Bootman, M. D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036035 · Cited by 5,701 · see citing works
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439 · see citing works
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224 · see citing works
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351 · see citing works
Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701 · see citing works
Self-citationTRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Rao, A., Luo, C. H., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,592 · see citing works
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483 · see citing works
Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., & Martin, T. J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0367 · Cited by 2,317 · see citing works
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290 · see citing works
Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856 · see citing works
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789 · see citing works
Genetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. (2003) · Nature reviews genetics · doi:10.1038/nrg1122 · Cited by 1,733 · see citing works
Reaching a Genetic and Molecular Understanding of Skeletal Development
Karsenty, G., & Wagner, E. F. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00157-0 · Cited by 1,594 · see citing works
T-Cell mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ.
Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A., Yokochi, T., Oda, H., Tanaka, K., et al. (2000) · Nature · doi:10.1038/35046102 · Cited by 1,358 · see citing works
Self-citationCrabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323 · see citing works
Bohmann, D., Bos, T. J., Admon, A., Nishimura, T., Vogt, P. K., & Tjian, R. (1987) · Science · doi:10.1126/science.2825349 · Cited by 1,321 · see citing works
c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
Grigoriadis, A. E., Wang, Z., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., & Wagner, E. F. (1994) · Science · doi:10.1126/science.7939685 · Cited by 1,260 · see citing works
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint
Lomaga, M. A., Yeh, W., Sarosi, I., Duncan, G. S., Furlonger, C. L., Ho, A. P., Morony, S., Capparelli, C., Van, G. Y., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,253 · see citing works
Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?
Feldmann, M., & Maini, R. N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.163 · Cited by 1,252 · see citing works
Ninomiya‐Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J., Cao, Z., & Matsumoto, K. (1999) · Nature · doi:10.1038/18465 · Cited by 1,187 · see citing works
Wong, B. R., Rho, J., Arron, J. R., Robinson, E. A., Orlinick, J. R., Chao, M. V., Kalachikov, S. M., Cayani, E., Bartlett, F. S., Frankel, W. N., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25190 · Cited by 1,042 · see citing works
Requirement for NF-κB in osteoclast and B-cell development
Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., & Siebenlist, U. (1997) · Genes & Development · doi:10.1101/gad.11.24.3482 · Cited by 996 · see citing works
Identification of a Putative Regulator of Early T Cell Activation Genes
Shaw, J., Utz, P. J., Durand, D. B., Toole, J. J., Emmel, E. A., & Crabtree, G. R. (1988) · Science · doi:10.1126/science.3260404 · Cited by 946 · see citing works
OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION
Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J. M., Martin, T. J., & Suda, T. (1988) · Endocrinology · doi:10.1210/endo-123-5-2600 · Cited by 934 · see citing works
Natural killer cells, viruses and cancer
Cerwenka, A., & Lanier, L. L. (2001) · Nature reviews. Immunology · doi:10.1038/35095564 · Cited by 874 · see citing works
Arron, J. R., & Choi, Y. (2000) · Nature · doi:10.1038/35046196 · Cited by 828 · see citing works
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., et al. (2004) · Nature · doi:10.1038/nature02444 · Cited by 826 · see citing works
Self-citationRANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution
Theill, L. E., Boyle, W. J., & Penninger, J. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064753 · Cited by 817 · see citing works
Bekker, P. J., Holloway, D. L., Rasmussen, A. S., Murphy, R., Martin, S. W., Leese, P. T., Holmes, G. B., Dunstan, C. R., & DePaoli, A. M. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040305 · Cited by 770 · see citing works
McGill, G. G., Horstmann, M. A., Widlund, H. R., Du, J., Motyckova, G., Nishimura, E. K., Lin, Y., Ramaswamy, S., Avery, W., Ding, H., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00762-6 · Cited by 760 · see citing works
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β
Takayanagi, H., Kim, S., Matsuo, K., Suzuki, H. I., Suzuki, T., Sato, K., Yokochi, T., Oda, H., Nakamura, K., Ida, N., et al. (2002) · Nature · doi:10.1038/416744a · Cited by 719 · see citing works
Self-citationPaloneva, J., Manninen, T., Christman, G., Hovanes, K., Mandelin, J., Adolfsson, R., Bianchin, M., Bird, T., Miranda, R., Salmaggi, A., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342259 · Cited by 683 · see citing works
Roles of Fc receptors in autoimmunity
Takai, T. (2002) · Nature reviews. Immunology · doi:10.1038/nri856 · Cited by 627 · see citing works
Naito, A., Azuma, S., Tanaka, S., Miyazaki, T., Takaki, S., Takatsu, K., Nakao, K., Nakamura, K., Katsuki, M., Yamamoto, T. S., et al. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00265.x · Cited by 626 · see citing works
Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos
Matsuo, K., Galson, D. L., Chen, Z., Peng, L., Laplace, C., Wang, K. Z. Q., Bachler, M. A., Amano, H., Aburatani, H., Ishikawa, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313973200 · Cited by 569 · see citing works
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1
Tondravi, M. M., McKercher, S. R., Anderson, K., Erdmann, J. M., Quiroz, M. E., Maki, R. A., & Teitelbaum, S. L. (1997) · Nature · doi:10.1038/386081a0 · Cited by 537 · see citing works
Franza, B. R., Rauscher, F. J., Josephs, S. F., & Curran, T. (1988) · Science · doi:10.1126/science.2964084 · Cited by 515 · see citing works
Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
Hughes, A. E., Ralston, S. H., Marken, J., Bell, C., Macpherson, H. K., Wallace, R. G. H., Hul, W. V., Whyte, M. P., Nakatsuka, K., Hovy, L., et al. (2000) · Nature Genetics · doi:10.1038/71667 · Cited by 481 · see citing works
Fra-1 replaces c-Fos-dependent functions in micePreprint
Fleischmann, A., Hafezi, F., Elliott, C., Remé, C. E., Rüther, U., & Wagner, E. F. (2000) · Genes & Development · doi:10.1101/gad.187900 · Cited by 472 · see citing works
Segregation of TRAF6‐mediated signaling pathways clarifies its role in osteoclastogenesis
Kobayashi, N., Kadono, Y., Naito, A., Matsumoto, K., Yamamoto, T. S., Tanaka, S., & Inoue, J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1271 · Cited by 467 · see citing works
Ikeda, F., Nishimura, R., Matsubara, T., Tanaka, S., Inoue, J., Reddy, S. V., Hata, K., Yamashita, K., Hiraga, T., Watanabe, T., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419657 · Cited by 461 · see citing works
The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor
Wong, B. R., Josien, R., Lee, S. Y., Vologodskaia, M., Steinman, R. M., & Choi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28355 · Cited by 458 · see citing works
Osteoprotegerin Deficiency and Juvenile Paget's Disease
Whyte, M. P., Obrecht, S. E., Finnegan, P. M., Jones, J. L., Podgornik, M. N., McAlister, W. H., & Mumm, S. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013096 · Cited by 446 · see citing works
Mócsai, A., Humphrey, M., Ziffle, J. V. V., Hu, Y., Burghardt, A., Spusta, S. C., Majumdar, S., Lanier, L., Lowell, C., & Nakamura, M. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401602101 · Cited by 436 · see citing works
Matsumoto, M., Kogawa, M., Wada, S., Takayanagi, H., Tsujimoto, M., Katayama, S., Hisatake, K., & Nogi, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408795200 · Cited by 436 · see citing works
Self-citationIshida, N., Hayashi, K., Hoshijima, M., Ogawa, T., Koga, S., Miyatake, Y., Kumegawa, M., Kimura, T., & Takeya, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205063200 · Cited by 377 · see citing works
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
Kaifu, T., Nakahara, J., Inui, M., Mishima, K., Momiyama, T., Kaji, M., Sugahara, A., Koito, H., Ujike, A., Nakamura, A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16923 · Cited by 342 · see citing works
Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation
Matsuo, K., Owens, J., Tonko, M., Elliott, C., Chambers, T. J., & Wagner, E. F. (2000) · Nature Genetics · doi:10.1038/72855 · Cited by 341 · see citing works
David, J., Sabapathy, K., Hoffmann, O., Idarraga, M. H., & Wagner, E. F. (2002) · Journal of Cell Science · doi:10.1242/jcs.00082 · Cited by 334 · see citing works
DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features
Paloneva, J., Mandelin, J., Kiialainen, A., Böhling, T., Prudlo, J., Hakola, P., Haltia, M., Konttinen, Y. T., & Peltonen, L. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030027 · Cited by 318 · see citing works
Lagasse, E., & Weissman, I. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80290-1 · Cited by 287 · see citing works
Kim, S., Koga, T., Isobe, M., Kern, B., Yokochi, T., Chin, Y. E., Karsenty, G., Taniguchi, T., & Takayanagi, H. (2003) · Genes & Development · doi:10.1101/gad.1119303 · Cited by 278 · see citing works
Self-citationA Novel Member of the Leukocyte Receptor Complex Regulates Osteoclast Differentiation
Kim, N., Takami, M., Rho, J., Josien, R., & Choi, Y. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011681 · Cited by 274 · see citing works
Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1
Muegge, K., Williams, T. M., Kant, J. A., Karin, M., Chiu, R., Schmidt, A., Siebenlist, U. K., Young, H. A., & Durum, S. K. (1989) · Science · doi:10.1126/science.2799385 · Cited by 263 · see citing works
Impaired Differentiation of Osteoclasts in TREM-2–deficient Individuals
Cella, M., Buonsanti, C., Strader, C., Kondo, T., Salmaggi, A., & Colonna, M. (2003) · Journal of Experimental Medicine · doi:10.1084/jem.20022220 · Cited by 256 · see citing works
Hai, T., Liu, F., Allegretto, E. A., Karin, M., & Green, M. R. (1988) · Genes & Development · doi:10.1101/gad.2.10.1216 · Cited by 251 · see citing works
Takeshita, S., Namba, N., Zhao, J. J., Jiang, Y., Genant, H. K., Silva, M. J., Brodt, M. D., Helgason, C. D., Kalesnikoff, J., Rauh, M. J., et al. (2002) · Nature Medicine · doi:10.1038/nm752 · Cited by 250 · see citing works
Genetic control of skeletal development
Wagner, E. F., & Karsenty, G. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00228-8 · Cited by 226 · see citing works
Suppression of oncogene-induced transformation by a deletion mutant of c-jun.
Brown, P. H., Alani, R. M., Preis, L. H., Szabo, E. M., & Birrer, M. J. (1993) · PubMed · Cited by 224 · see citing works
Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects
Kenner, L., Hoebertz, A., Beil, F. T., Keon, N., Karreth, F. A., Eferl, R., Scheuch, H., Szremska, A., Amling, M., Schorpp‐Kistner, M., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200308155 · Cited by 208 · see citing works
Mechanism of action of a dominant-negative mutant of c-Jun.
Brown, P. H., Chen, T. K., & Birrer, M. J. (1994) · PubMed · Cited by 205 · see citing works
Whyte, M. P., & Hughes, A. E. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.26 · Cited by 180 · see citing works
Shirakawa, F., Chedid, M., Suttles, J., Pollok, B. A., & Mizel, S. B. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.3.959 · Cited by 178 · see citing works
Linkage of M-CSF Signaling to Mitf, TFE3, and the Osteoclast Defect in Mitfmi/mi Mice
Weilbaecher, K. N., Motyckova, G., Huber, W. E., Takemoto, C. M., Hemesath, T. J., Xu, Y., Hershey, C. L., Dowland, N., Wells, A. G., & Fisher, D. E. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00360-4 · Cited by 168 · see citing works
Aoki, K., DiDomenico, E., Sims, N. A., Mukhopadhyay, K., Neff, L., Houghton, A., Amling, M., Levy, J. B., Horne, W. C., & Baron, R. (1999) · Bone · doi:10.1016/s8756-3282(99)00174-x · Cited by 109 · see citing works
High dose M‐CSF partially rescues the Dap12−/− osteoclast phenotype
Faccio, R., Zou, W., Colaianni, G., Teitelbaum, S. L., & Ross, F. P. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10694 · Cited by 98 · see citing works
So, H., Rho, J., Jeong, D., Park, R., Fisher, D. E., Ostrowski, M. C., Choi, Y., & Kim, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302940200 · Cited by 96 · see citing works
Interfering with bone remodelling
Alliston, T. N., & Derynck, R. (2002) · Nature · doi:10.1038/416686a · Cited by 91 · see citing works
Shirakawa, F., Chedid, M., Suttles, J., Pollok, B. A., & Mizel, S. B. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.3.959-964.1989 · Cited by 55 · see citing works
Murine Matrix Metalloproteinase 9 Gene
Munaut, C., Salonurmi, T., Kontusaari, S., Reponen, P., Morita, T., Foidart, J., & Tryggvason, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5588 · Cited by 52 · see citing works
Baron, R. (2004) · Nature Medicine · doi:10.1038/nm0504-458 · Cited by 50 · see citing works
Dong, Z., Xu, R.-H., Kim, J., Zhan, S.-N., Ma, W.-Y., Colburn, N. H., & Kung, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9942 · Cited by 44 · see citing works
Hayashi, S., Tsuneto, M., Yamada, T., Nose, M., Yoshino, M., Shultz, L., & Yamazaki, H. (2004) · Endocrinology · doi:10.1210/en.2004-0172 · Cited by 16 · see citing works
Gravellese (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200002)43:2 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878 · see citing works
Self-citationFunctions of RANKL/RANK/OPG in bone modeling and remodeling
Boyce, B. F., & Xing, L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.018 · Cited by 1,844 · see citing works
Pathogenesis of osteoporosis: concepts, conflicts, and prospects
Raisz, L. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27071 · Cited by 1,779 · see citing works
Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061775 · Cited by 1,554 · see citing works
Self-citationThe molecular understanding of osteoclast differentiation
Asagiri, M., & Takayanagi, H. (2007) · Bone · doi:10.1016/j.bone.2006.09.023 · Cited by 1,363 · see citing works
Self-citationRANKL–RANK signaling in osteoclastogenesis and bone disease
Wada, T., Nakashima, T., Nishina, H., & Penninger, J. M. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.11.007 · Cited by 1,207 · see citing works
Biology of RANK, RANKL, and osteoprotegerin
Boyce, B. F., & Xing, L. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2165 · Cited by 962 · see citing works
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner, E. F., Mak, T. W., Serfling, E., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051150 · Cited by 849 · see citing works
Self-citationOSTEOIMMUNOLOGY: Interplay Between the Immune System and Bone Metabolism
Walsh, M. C., Kim, N., Kadono, Y., Rho, J., Lee, S. Y., Lorenzo, J., & Choi, Y. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090646 · Cited by 724 · see citing works
Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond
Walsh, M. C., & Choi, Y. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00511 · Cited by 599 · see citing works
Osteoimmunology: Interactions of the Bone and Immune System
Lorenzo, J., Horowitz, M. C., & Choi, Y. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0038 · Cited by 566 · see citing works
Fos/AP‐1 proteins in bone and the immune system
Wagner, E. F., & Eferl, R. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00332.x · Cited by 537 · see citing works
NFAT and Osterix cooperatively regulate bone formation
Koga, T., Matsui, Y., Asagiri, M., Kodama, T., Crombrugghe, B. D., Nakashima, K., & Takayanagi, H. (2005) · Nature Medicine · doi:10.1038/nm1270 · Cited by 490 · see citing works
Self-citationInflammatory mediators in the pathogenesis of periodontitis
Yucel‐Lindberg, T., & Båge, T. (2013) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2013.8 · Cited by 473 · see citing works
RANK/RANKL: Regulators of Immune Responses and Bone Physiology
Leibbrandt, A., & Penninger, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.016 · Cited by 420 · see citing works
Yamashita, T., Yao, Z., Li, F., Zhang, Q., Badell, I., Schwarz, E., Takeshita, S., Wagner, E., Noda, M., Matsuo, K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610701200 · Cited by 412 · see citing works
The Early Fracture Hematoma and Its Potential Role in Fracture Healing
Kolar, P., Schmidt‐Bleek, K., Schell, H., Gaber, T., Toben, D., Schmidmaier, G., Perka, C., Buttgereit, F., & Duda, G. N. (2010) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2009.0687 · Cited by 404 · see citing works
Bone Remodeling in Post-menopausal Osteoporosis
Lerner, U. H. (2006) · Journal of Dental Research · doi:10.1177/154405910608500703 · Cited by 348 · see citing works
Boyce, B. F., & Xing, L. (2007) · Current Osteoporosis Reports · doi:10.1007/s11914-007-0024-y · Cited by 339 · see citing works
Immunology of Osteoporosis: A Mini-Review
Pietschmann, P., Mechtcheriakova, D., Meshcheryakova, A., Föger‐Samwald, U., & Ellinger, I. (2015) · Gerontology · doi:10.1159/000431091 · Cited by 289 · see citing works
Inflammatory bone destruction and osteoimmunology
Takayanagi, H. (2005) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2005.00814.x · Cited by 267 · see citing works
Self-citationMafB negatively regulates RANKL-mediated osteoclast differentiation
Kim, K., Kim, J. H., Lee, J., Jin, H. M., Kook, H. Y., Kim, K. K., Lee, S. Y., & Kim, N. (2006) · Blood · doi:10.1182/blood-2006-09-048249 · Cited by 264 · see citing works
Weitzmann, M. (2013) · Scientifica · doi:10.1155/2013/125705 · Cited by 270 · see citing works
Mechanisms and control of pathologic bone loss in periodontitis
Bartold, P. M., Cantley, M. D., & Haynes, D. R. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00347.x · Cited by 252 · see citing works
Kim, K., Kim, J. H., Lee, J., Jin, H., Lee, S., Fisher, D. E., Kook, H. Y., Kim, K. K., Choi, Y., & Kim, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505815200 · Cited by 247 · see citing works
Role of ITAM‐containing adapter proteins and their receptors in the immune system and bone
Humphrey, M. B., Lanier, L. L., & Nakamura, M. C. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00325.x · Cited by 241 · see citing works
Flavonoids: Classification, Function, and Molecular Mechanisms Involved in Bone Remodelling
Ramesh, P., Jagadeesan, R., Sekaran, S., Dhanasekaran, A., & Vimalraj, S. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.779638 · Cited by 232 · see citing works
Osteoclast precursors, RANKL/RANK, and immunology
Xing, L., Schwarz, E. M., & Boyce, B. F. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00336.x · Cited by 234 · see citing works
Osteoclasts, rheumatoid arthritis, and osteoimmunology
Sato, K., & Takayanagi, H. (2006) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000231912.24740.a5 · Cited by 222 · see citing works
Self-citationKim, M. S., Yang, Y., Son, A., Tian, Y. S., Lee, S.-I., Kang, S. W., Muallem, S., & Shin, D. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.051557 · Cited by 207 · see citing works
Kim, Y., Sato, K., Asagiri, M., Morita, I., Soma, K., & Takayanagi, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505820200 · Cited by 198 · see citing works
Self-citationOsteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption
Boyce, B. F., Yao, Z., & Xing, L. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i3.10 · Cited by 197 · see citing works
Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells
Soltanoff, C. S., Yang, S., Chen, W., & Li, Y. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i1.10 · Cited by 196 · see citing works
High glucose concentrations alter the biomineralization process in human osteoblastic cells
García‐Hernández, A. L., Arzate, H., Gil-Chavarría, I., Rojo, R., & Moreno‐Fierros, L. (2011) · Bone · doi:10.1016/j.bone.2011.10.032 · Cited by 216 · see citing works
Interplay between interferon and other cytokine systems in bone metabolism
Takayanagi, H., Sato, K., Takaoka, A., & Taniguchi, T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00337.x · Cited by 192 · see citing works
Self-citationBoon and Bane of Inflammation in Bone Tissue Regeneration and Its Link with Angiogenesis
Schmidt‐Bleek, K., Kwee, B. J., Mooney, D. J., & Duda, G. N. (2015) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2014.0677 · Cited by 182 · see citing works
Regulation of osteoclast function and bone mass by RAGE
Zhou, Z., Immel, D., Xi, C.-X., Bierhaus, A., Feng, X., Mei, L., Nawroth, P., Stern, D. M., & Xiong, W.-C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051947 · Cited by 178 · see citing works
Walsh, M. C., Kim, G. K., Maurizio, P. L., Molnar, E. E., & Choi, Y. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004064 · Cited by 175 · see citing works
Palmqvist, P., Lundberg, P., Persson, E., Johansson, A., Lundgren, I., Lie, A., Conaway, H. H., & Lerner, U. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510160200 · Cited by 167 · see citing works
Role of nuclear factor‐κB in the immune system and bone
Jimi, E., & Ghosh, S. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00329.x · Cited by 164 · see citing works
Huang, H., Chang, E.-J., Ryu, J., Lee, Z. H., Lee, Y., & Kim, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.011 · Cited by 161 · see citing works
HMGB1 Regulates RANKL-Induced Osteoclastogenesis in a Manner Dependent on RAGE
Zhou, Z., Han, J.-Y., Xi, C.-X., Xie, J.-X., Feng, X., Wang, C.-Y., Mei, L., & Xiong, W.-C. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080234 · Cited by 160 · see citing works
Calcineurin regulates bone formation by the osteoblast
Sun, L., Blair, H. C., Peng, Y., Zaidi, N., Adebanjo, O. A., Wu, X. B., Wu, X. Y., Iqbal, J. Z., Epstein, S., Abe, E., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508480102 · Cited by 159 · see citing works
MicroRNA-124 regulates osteoclast differentiation
Lee, Y., Kim, H. J., Park, C., Kim, Y., Lee, H., Kim, J., & Kim, H. (2013) · Bone · doi:10.1016/j.bone.2013.07.007 · Cited by 158 · see citing works
Ji, J.-D., Park‐Min, K., Shen, Z., Fajardo, R. J., Goldring, S. R., McHugh, K. P., & Ivashkiv, L. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900072 · Cited by 158 · see citing works
Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts
Komano, Y., Nanki, T., Hayashida, K., Taniguchi, K., & Miyasaka, N. (2006) · Arthritis Research & Therapy · doi:10.1186/ar2046 · Cited by 154 · see citing works
Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1
Anderson, G., Gries, M., Kurihara, N., Honjo, T., Anderson, J., Donnenberg, V. S., Donnenberg, A. D., Ghobrial, I. M., Mapara, M. Y., Stirling, D., et al. (2005) · Blood · doi:10.1182/blood-2005-08-3450 · Cited by 148 · see citing works
Koga, Y., Tsurumaki, H., Aoki‐Saito, H., Sato, M., Yatomi, M., Takehara, K., & Hisada, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061346 · Cited by 149 · see citing works
TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3
Besse, A., Lamothe, B., Campos, A. D., Webster, W. K., Maddineni, U., Lin, S., Wu, H., & Darnay, B. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608867200 · Cited by 145 · see citing works
Secretion of tartrate‐resistant acid phosphatase by osteoclasts correlates with resorptive behavior
Kirstein, B., Chambers, T. J., & Fuller, K. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20835 · Cited by 145 · see citing works
Kyere, K. A., Than, K. D., Wang, A., Rahman, S. U., Valdivia–Valdivia, J. M., Marca, F. L., & Park, P. (2012) · European Spine Journal · doi:10.1007/s00586-012-2325-9 · Cited by 138 · see citing works
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation
Lamothe, B., Webster, W. K., Gopinathan, A., Besse, A., Campos, A. D., & Darnay, B. G. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.06.017 · Cited by 134 · see citing works
Osteoclast differentiation and gene regulation
Zhao, Q. (2006) · Frontiers in bioscience · doi:10.2741/2252 · Cited by 129 · see citing works
Kameda, Y., Takahata, M., Komatsu, M., Mikuni, S., Hatakeyama, S., Shimizu, T., Angata, T., Kinjo, M., Minami, A., & Iwasaki, N. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1989 · Cited by 128 · see citing works
The Regulation of Cathepsin K Gene Expression
Troen, B. R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1346.018 · Cited by 125 · see citing works
Park‐Min, K., Ji, J.-D., Antoniv, T. T., Reid, A. C., Silver, R. B., Humphrey, M. B., Nakamura, M. C., & Ivashkiv, L. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804165 · Cited by 122 · see citing works
Nagasawa, T., Kiji, M., Yashiro, R., Hormdee, D., Lu, H., Kunze, M., Suda, T., Koshy, G., Kobayashi, H., Oda, S., et al. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00185.x · Cited by 121 · see citing works
Pathological role of osteoclast costimulation in arthritis-induced bone loss
Ochi, S., Shinohara, M., Sato, K., Gober, H.-J., Koga, T., Kodama, T., Takai, T., Miyasaka, N., & Takayanagi, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701971104 · Cited by 119 · see citing works
Self-citationMechanisms of Disease: molecular insights into aseptic loosening of orthopedic implants
Drees, P., Eckardt, A., Gay, R. E., Gay, S., & Huber, L. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0428 · Cited by 119 · see citing works
Crotti, T. N., Dharmapatni, A. A. S. S. K., Alias, E., & Haynes, D. R. (2015) · Journal of Immunology Research · doi:10.1155/2015/281287 · Cited by 112 · see citing works
Cross-Presentation by Osteoclasts Induces FoxP3 in CD8+ T Cells
Kiesel, J. R., Buchwald, Z. S., & Aurora, R. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803897 · Cited by 109 · see citing works
Algate, K., Haynes, D. R., Bartold, P. M., Crotti, T. N., & Cantley, M. D. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12339 · Cited by 108 · see citing works
The role of SH3BP2 in the pathophysiology of cherubism
Reichenberger, E., Levine, M. A., Olsen, B. R., Papadaki, M. E., & Lietman, S. A. (2012) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-7-s1-s5 · Cited by 108 · see citing works
Kim, H., Choi, H. K., Shin, J. H., Kim, K., Huh, J. Y., Lee, S. A., Ko, C., Kim, H.-S., Shin, H.-I., Jeong, D., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36809 · Cited by 106 · see citing works
Cellular and molecular pathways of structural damage in rheumatoid arthritis
Steffen, U., & Schett, G. A. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0634-0 · Cited by 105 · see citing works
Joyce-Shaikh, B., Bigler, M. E., Chao, C., Murphy, E. E., Blumenschein, W. M., Adamopoulos, I. E., Heyworth, P. G., Antonenko, S. V., Bowman, E. P., McClanahan, T. K., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20090516 · Cited by 101 · see citing works
Wnt signalling pathway: a new target for the treatment of osteoporosis
Rawadi, G., & Roman‐Roman, S. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.5.1063 · Cited by 93 · see citing works
Murine Osteoclast Formation and Function: Differential Regulation by Humoral Agents
Fuller, K., Kirstein, B., & Chambers, T. J. (2005) · Endocrinology · doi:10.1210/en.2005-1340 · Cited by 88 · see citing works
Kalliolias, G. D., Zhao, B., Triantafyllopoulou, A., Park‐Min, K., & Ivashkiv, L. B. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27200 · Cited by 88 · see citing works
Bisphosphonates, Old Friends of Bones and New Trends in Clinics
Barbosa, J. S., Paz, F. A. A., & Braga, S. S. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01292 · Cited by 87 · see citing works
Darnay, B. G., Besse, A., Poblenz, A. T., Lamothe, B., & Jacoby, J. J. (2007) · Springer eBooks · doi:10.1007/978-0-387-70630-6_12 · Cited by 84 · see citing works
Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis
Cantley, M. D., Fairlie, D. P., Bartold, P. M., Marino, V., Gupta, P. K., & Haynes, D. R. (2015) · Rheumatology · doi:10.1093/rheumatology/kev022 · Cited by 81 · see citing works
Wu, H., Hu, B., Zhou, X., Zhou, C., Meng, J., Yang, Y., Zhao, X., Shi, Z., & Yan, S. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0540-y · Cited by 81 · see citing works
Venkatesha, S. H., Berman, B., & Moudgil, K. D. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.10.053 · Cited by 80 · see citing works
Calmodulin is a critical regulator of osteoclastic differentiation, function, and survival
Seales, E. C., Micoli, K., & McDonald, J. M. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20659 · Cited by 79 · see citing works
Tanshinone IIA inhibits osteoclast differentiation through down-regulation of c-Fos and NFATc1
Kwak, H. B., Yang, D., Ha, H., Lee, J.-H., Kim, H., Woo, E.-R., Lee, S., Kim, H., & Lee, Z. H. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.31 · Cited by 78 · see citing works
Lee, W., Lee, E., Sung, M.-S., & Yoo, W. (2014) · Inflammation · doi:10.1007/s10753-014-9849-6 · Cited by 77 · see citing works
Inflammation-Induced Bone Loss: Can it Be Prevented?
Romas, E., & Gillespie, M. T. (2006) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2006.07.004 · Cited by 78 · see citing works
Shang, W., Zhao, L.-J., Dong, X., Zhao, Z.-M., Li, J., Zhang, B., & Cai, H. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5674 · Cited by 77 · see citing works
BSP and RANKL Induce Osteoclastogenesis and Bone Resorption Synergistically
Valverde, P., Tu, Q., & Chen, J. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050511 · Cited by 76 · see citing works
VEGF and RANKL Regulation of NFATc1 in Heart Valve Development
Combs, M. D., & Yutzey, K. E. (2009) · Circulation Research · doi:10.1161/circresaha.109.196469 · Cited by 76 · see citing works
César‐Neto, J. B., Duarte, P. M., Oliveira, M. C. G., Tambeli, C. H., Sallum, E. A., & Nociti, F. H. (2006) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00934.x · Cited by 76 · see citing works
Water-soluble fullerene (c60) inhibits the development of arthritis in the rat model of arthritis
Yudoh, K. (2009) · International Journal of Nanomedicine · doi:10.2147/ijn.s7653 · Cited by 75 · see citing works
Li, B., Wang, P., Jiao, J., Wei, H., Xu, W., & Zhou, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.824117 · Cited by 77 · see citing works
Lee, S.-Y., Lee, K.-S., Yi, S. H., Kook, S., & Lee, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080873 · Cited by 72 · see citing works
Novel osteoclast signaling mechanisms
Shinohara, M., & Takayanagi, H. (2007) · Current Osteoporosis Reports · doi:10.1007/s11914-007-0005-1 · Cited by 72 · see citing works
Self-citationPike, J. W., Lee, S. M., & Meyer, M. B. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.216 · Cited by 71 · see citing works
Bone inflammation and altered gene expression with type I diabetes early onset
Motyl, K. J., Boțolin, S., Irwin, R., Appledorn, D. M., Kadakia, T., Amalfitano, A., Schwartz, R. C., & McCabe, L. R. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21626 · Cited by 71 · see citing works
Liu, F.-X., Zhu, Z., Mao, Y.-Q., Liu, M., Tang, T.-T., & Qiu, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.018 · Cited by 68 · see citing works
Clastic cells: Mineralized tissue resorption in health and disease
Arana-Chavez, V. E., & Bradaschia-Correa, V. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.09.007 · Cited by 69 · see citing works
Tsubaki, M., Komai, M., Itoh, T., Imano, M., Sakamoto, K., Shimaoka, H., Takeda, T., Ogawa, N., Mashimo, K., Fujiwara, D., et al. (2014) · Journal of Biomedical Science · doi:10.1186/1423-0127-21-10 · Cited by 70 · see citing works
Thummuri, D., Naidu, V. G. M., & Chaudhari, P. R. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1553-1 · Cited by 69 · see citing works
Balkan, W., Martinez, A. F., Fernández, I. C., Rodriguez, M. A., Pang, M., & Troen, B. R. (2009) · Gene · doi:10.1016/j.gene.2009.06.013 · Cited by 68 · see citing works
Osteoclasts—the innate immune cells of the bone
Wu, Y., Humphrey, M. B., & Nakamura, M. C. (2008) · Autoimmunity · doi:10.1080/08916930701693180 · Cited by 67 · see citing works
Pang, M., Rodríguez‐Gonzalez, M., Hernandez, M., Recinos, C. C., Seldeen, K. L., & Troen, B. R. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28504 · Cited by 66 · see citing works
Inhibitory effect of luteolin on osteoclast differentiation and function
Lee, J., Ahn, J.-Y., Hasegawa, S., Cha, B., Yonezawa, T., Nagai, K., Seo, H.-J., Jeon, W., & Woo, J. (2009) · Cytotechnology · doi:10.1007/s10616-010-9253-5 · Cited by 62 · see citing works
Inositol Polyphosphate 4-Phosphatase B as a Regulator of Bone Mass in Mice and Humans
Ferron, M., Boudiffa, M., Arsenault, M., Rached, M., Pata, M., Giroux, S., Elfassihi, L., Kisseleva, M. V., Majerus, P. W., Rousseau, F., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.013 · Cited by 61 · see citing works
MSU crystal deposition contributes to inflammation and immune responses in gout remission
Gu, H., Yu, H., Qin, L., Yu, H., Song, Y., Chen, G., Zhao, D., Wang, S., Xue, W., Wang, L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113139 · Cited by 59 · see citing works
Mundy, G. R., Oyajobi, B. O., Gutierrez, G. E., Sterling, J. A. R., Padalecki, S. S., Elefteriou, F., & Zhao, M. (2008) · Elsevier eBooks · doi:10.1016/b978-012370544-0.50020-3 · Cited by 59 · see citing works
Zhu, S., Yan, M.-Q., Masson, A., Chen, W. "., & Li, Y. (2026) · Cell Discovery · doi:10.1038/s41421-025-00853-6 · Cited by 64 · see citing works
- Authors
- Takayanagi, H.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Corresponding author
- Takayanagi, Hiroshi
- Venue
- Journal of Molecular Medicine
- Published
- 2005-01-26
- Volume
- 83
- Issue
- 3
- Pages
- 170-179
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2124273389
- Cited by
- 413
- References
- 76
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 13 · 2017: 17 · 2016: 16 · 2015: 24 · 2014: 24 · 2013: 18 · 2012: 26
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Takeda Science Foundation
- Mitsubishi Foundation
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- osteoclastogenesis, osteoimmunology, RANKL, TRAF6, c-fos, NFATc1, AP-1, ITAM signaling, FcRγ, DAP12, osteoclast-associated receptor, traps, TLR2, TLR4, phospholipase C-gamma, calcium signaling
- MeSH terms
- Animals, Carrier Proteins, Cell Differentiation, Humans, Membrane Glycoproteins, Osteoclasts, Receptors, Immunologic, Transcription Factors, Signal Transduction, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B
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