Histone deacetylase inhibitors: Anticancer compounds

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

Minucci, S., & Pelicci, P. G. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1779 · Cited by 2,211 · see citing works

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,889 · see citing works

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Finnin, M. S., Donigian, J. R., Cohen, A., Richon, V. M., Rifkind, R. A., Marks, P. A., Breslow, R., & Pavletich, N. P. (1999) · Nature · doi:10.1038/43710 · Cited by 1,714 · see citing works

Acetylation and deacetylation of non-histone proteins

Glozak, M. A., Sengupta, N., Zhang, X., & Seto, E. (2005) · Gene · doi:10.1016/j.gene.2005.09.010 · Cited by 1,584 · see citing works

FDA Approval Summary: Vorinostat for Treatment of Advanced Primary Cutaneous T-Cell Lymphoma

Mann, B. S., Johnson, J. R., Cohen, M. H., Justice, R., & Pazdur, R. (2007) · The Oncologist · doi:10.1634/theoncologist.12-10-1247 · Cited by 1,365 · see citing works

Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

Richon, V. M., Sandhoff, T. W., Rifkind, R. A., & Marks, P. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180316197 · Cited by 1,090 · see citing works

Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer

Kelly, W. K., O’Connor, O. A., Krug, L. M., Chiao, J. H., Heaney, M. L., Curley, T., MacGregor‐Cortelli, B., Tong, W. P., Secrist, J. P., Schwartz, L. B., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.14.167 · Cited by 906 · see citing works

Regulation of E2F1 activity by acetylation

Martínez‐Balbás, M. A., Bauer, U., Nielsen, S. J., Brehm, A., & Kouzarides, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.662 · Cited by 670 · see citing works

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Vannini, A., Volpari, C., Filocamo, G., Casavola, E. C., Brunetti, M., Renzoni, D., Chakravarty, P., Paolini, C., De Francesco, R., Gallinari, P., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404603101 · Cited by 638 · see citing works

Discovery and development of SAHA as an anticancer agent

Marks, P. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210204 · Cited by 637 · see citing works

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

Peart, M. J., Smyth, G. K., van Laar, R. K., Bowtell, D. D. L., Richon, V. M., Marks, P. A., Holloway, A. J., & Johnstone, R. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500369102 · Cited by 538 · see citing works

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

Krämer, O. H., Zhu, P., Ostendorff, H. P., Golebiewski, M., Tiefenbach, J., Peters, M. A., Brill, B., Groner, B., Bach, I., Heinzel, T., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg315 · Cited by 523 · see citing works

Untitled work

(2003) · PubMed · Cited by 519 · see citing works

Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.

Warrell, R. P., He, L.-Z., Richon, V., Calleja, E., & Pandolfi, P. P. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.21.1621 · Cited by 502 · see citing works

Rapid Alteration of MicroRNA Levels by Histone Deacetylase Inhibition

Scott, G. K., Mattie, M. D., Berger, C. E., Benz, S. C., & Benz, C. C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3632 · Cited by 493 · see citing works

Histone Deacetylase Inhibitors Radiosensitize Human Melanoma Cells by Suppressing DNA Repair Activity

Munshi, A., Kurland, J. F., Nishikawa, T., Tanaka, T., Hobbs, M. L., Tucker, S. L., Ismail, S. M., Stevens, C., & Meyn, R. E. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2088 · Cited by 345 · see citing works

Class II Histone Deacetylases Are Associated with VHL-Independent Regulation of Hypoxia-Inducible Factor 1α

Qian, D. Z., Kachhap, S. K., Collis, S. J., Verheul, H. M. W., Carducci, M. A., Atadja, P. W., & Пили, Р. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4598 · Cited by 302 · see citing works

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

Ropero, S., Fraga, M. F., Ballestar, E., Hamelin, R., Yamamoto, H., Boix-Chornet, M., Caballero, R., Alaminos, M., Setién, F., Paz, M. F., et al. (2006) · Nature Genetics · doi:10.1038/ng1773 · Cited by 290 · see citing works

Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

Vrana, J. A., Decker, R. H., Johnson, C. R., Wang, Z., Jarvis, W. D., Richon, V. M., Ehinger, M., Fisher, P. B., & Grant, S. (1999) · Oncogene · doi:10.1038/sj.onc.1203176 · Cited by 285 · see citing works

Acetylation of p53 at Lysine 373/382 by the Histone Deacetylase Inhibitor Depsipeptide Induces Expression of p21Waf1/Cip1

Zhao, Y., Lu, S., Wu, L., Chai, G., Wang, H., Chen, Y., Sun, J. T., Yu, Y., Zhou, W., Zheng, Q., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2782-2790.2006 · Cited by 277 · see citing works

Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design

Hodawadekar, S. C., & Marmorstein, R. (2007) · Oncogene · doi:10.1038/sj.onc.1210619 · Cited by 271 · see citing works

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

Schuetz, A., Min, J., Allali‐Hassani, A., Schapira, M., Shuen, M., Loppnau, P., Mazitschek, R., Kwiatkowski, N. P., Lewis, T. A., Maglathin, R. L., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707362200 · Cited by 261 · see citing works

Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim

Zhao, Y., Tan, J. Y., Zhuang, L., Jiang, X., Liu, E. T., & Yu, Q. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505585102 · Cited by 246 · see citing works

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

Kim, Y. B., Lee, K.-H., Sugita, K., Yoshida, M., & Horinouchi, S. (1999) · Oncogene · doi:10.1038/sj.onc.1202564 · Cited by 232 · see citing works

Role of Class I and Class II histone deacetylases in carcinoma cells using siRNA

Glaser, K. B., Li, J., Staver, M. J., Wei, R.-Q., Albert, D. H., & Davidsen, S. K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.043 · Cited by 220 · see citing works

Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2

Lin, Y.-C., Lin, J., Chou, C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5807 · Cited by 199 · see citing works

Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

Lindemann, R. K., Newbold, A., Whitecross, K. F., Cluse, L. A., Frew, A. J., Ellis, L., Williams, S. P., Wiegmans, A. P., Dear, A. E., Scott, C. L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702294104 · Cited by 199 · see citing works

HDAC1 Acetylation Is Linked to Progressive Modulation of Steroid Receptor-Induced Gene Transcription

Qiu, Y., Zhao, Y., Becker, M., John, S., Parekh, B. S., Huang, S., Hendarwanto, A., Martínez, E. D., Chen, Y., Lu, H., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.019 · Cited by 184 · see citing works

Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells

Kumagai, T., Wakimoto, N., Yin, D., Gery, S., Kawamata, N., Takai, N., Komatsu, N., Чумаков, А. Е., Imai, Y., & Koeffler, H. P. (2007) · International Journal of Cancer · doi:10.1002/ijc.22558 · Cited by 181 · see citing works

Inhibition of Histone Deacetylases Promotes Ubiquitin-Dependent Proteasomal Degradation of DNA Methyltransferase 1 in Human Breast Cancer Cells

Zhou, Q. Y., Agoston, A. T., Atadja, P. W., Nelson, W. G., & Davidson, N. E. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-07-0330 · Cited by 167 · see citing works

Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor α, in response to deacetylase inhibition by valproic acid and trichostatin A

Reid, G., Métivier, R., Lin, C., Denger, S., Ibberson, D., Ivacevic, T., Brand, H., Beneš, V., Liu, E. T., & Gannon, F. (2005) · Oncogene · doi:10.1038/sj.onc.1208662 · Cited by 152 · see citing works

Regulation of the HIF-1α stability by histone deacetylases

Kim, S. H., Jeong, J.-W., Park, J. Y., Lee, J., Seo, J., Jung, B., Bae, M., & Kim, K. (2007) · Oncology Reports · doi:10.3892/or.17.3.647 · Cited by 144 · see citing works

Histone Deacetylase Inhibitors Decrease DNA Methyltransferase-3B Messenger RNA Stability and Down-regulate De novo DNA Methyltransferase Activity in Human Endometrial Cells

Xiong, Y., Dowdy, S. C., Podratz, K. C., Jin, F., Attewell, J. R., Eberhardt, N. L., & Jiang, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2843 · Cited by 139 · see citing works

Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB

Joseph, J., Mudduluru, G., Antony, S., Vashistha, S., Ajitkumar, P., & Somasundaram, K. (2004) · Oncogene · doi:10.1038/sj.onc.1207852 · Cited by 128 · see citing works

Histone Deacetylase Inhibitor Depsipeptide Activates Silenced Genes through Decreasing both CpG and H3K9 Methylation on the Promoter

Wu, L., Wang, X., Li, L., Zhao, Y., Lu, S., Yu, Y., Zhou, W., Liu, X., Yang, J., Zheng, Z., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01516-07 · Cited by 123 · see citing works

SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells

Komatsu, N., Kawamata, N., Takeuchi, S., et al. (2006) · Oncology Reports · doi:10.3892/or.15.1.187 · Cited by 117 · see citing works

Histone Deacetylase Inhibitor Trichostatin A Represses Estrogen Receptor α-Dependent Transcription and Promotes Proteasomal Degradation of Cyclin D1 in Human Breast Carcinoma Cell Lines

Alao, J. P., Lam, E. W. ‐., Ali, S., Buluwela, L., Bordogna, W., Lockey, P. M., Varshochi, R., Stavropoulou, A. V., Coombes, R. C., & Vigushin, D. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1023 · Cited by 110 · see citing works

Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate

Sekhavat, A., Sun, J., & Davie, J. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-145 · Cited by 108 · see citing works

Direct Inhibition of the Expression of Cyclin D1 Gene by Sodium Butyrate

Lallemand, F., Courilleau, D., Sabbah, M., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1774 · Cited by 105 · see citing works

Histone deacetylase inhibitors selectively suppress expression of HDAC7

Dokmanovic, M., Perez, G., Xu, W., Ngo, L., Clarke, C., Parmigiani, R. B., & Marks, P. A. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0251 · Cited by 100 · see citing works

The methyl-CpG binding protein MBD1 is required for PML-RARα function

Villa, R., Morey, L., Raker, V. A., Buschbeck, M., Gutiérrez, A., Santis, F. D., Corsaro, M., Varas, F., Bossi, D., Minucci, S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509343103 · Cited by 100 · see citing works

Histone Deacetylase Inhibition Down-Regulates Cyclin D1 Transcription by Inhibiting Nuclear Factor-κB/p65 DNA Binding

Hu, J., & Colburn, N. H. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-04-0070 · Cited by 98 · see citing works

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

Hahn, C. K., Ross, K. N., Warrington, I. M., Mazitschek, R., Kanegai, C. M., Wright, R. D., Kung, A. L., Golub, T. R., & Stegmaier, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710413105 · Cited by 91 · see citing works

Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells

You, J. S., Kang, J., Lee, E. K., Lee, J., Lee, S. H., Jeon, Y. J., Koh, D. H., Ahn, S., Seo, D.-W., Lee, H. Y., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210776 · Cited by 76 · see citing works

Mechanism for ubiquitylation of the leukemia fusion proteins AML1‐ETO and PML‐RARα

Krämer, O. H., Müller, S., Buchwald, M., Reichardt, S., & Heinzel, T. (2007) · The FASEB Journal · doi:10.1096/fj.06-8050com · Cited by 72 · see citing works

Valproic Acid Sensitizes Chronic Lymphocytic Leukemia Cells to Apoptosis and Restores the Balance Between Pro- and Antiapoptotic Proteins

Bokelmann, I., & Mahlknecht, U. (2008) · Molecular Medicine · doi:10.2119/2007-00084.bokelmann · Cited by 54 · see citing works

Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells

Im, J. Y., Park, H.-Y., Kang, K. W., et al. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.01.007 · Cited by 47 · see citing works

Effects of FR235222, a novel HDAC inhibitor, in proliferation and apoptosis of human leukaemia cell lines: Role of Annexin A1

Petrella, A., D’Acunto, C. W., Rodriquez, M., et al. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.01.023 · Cited by 47 · see citing works

Linkages of nuclear architecture to biological and pathological control of gene expression

Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Pockwinse, S. M., & McNeil, S. M. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1998)72:30/31+ · Cited by 6 · see citing works

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

Miller, K. M., Tjeertes, J. V., Coates, J., Legube, G., Polo, S. E., Britton, S., & Jackson, S. P. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1899 · Cited by 629 · see citing works

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

Delcuve, G. P., Khan, D. H., & Davie, J. R. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-5 · Cited by 505 · see citing works

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

Bressi, J. C., Jennings, A. J., Skene, R., Wu, Y., Melkus, R., Jong, R. D., O’Connell, S., Grimshaw, C. E., Navre, M., & Gangloff, A. R. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.03.091 · Cited by 261 · see citing works

A Sensitive and Flexible Assay for Determining Histone Deacetylase 1 (HDAC1) Activity

Wu, M.-Y., & Wu, R. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3667-0_1 · Cited by 1 · see citing works

Progress in the research of histone deacetylase inhibitors

Liu, D. (2006) · Zhongguo yaowu huaxue zazhi

Purification of a histone deacetylase complex from Xenopus laevis: Preparation of substrates and assay procedures

Wade, P. A., Jones, P. L., Vermaak, D., et al. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)04043-4 · Cited by 17 · see citing works

Advances in pharmacological study of histone deacetylase inhibitors

Na, L. (2004) · Chinese New Drugs Journal

HDAC inhibitors as anti‐inflammatory agents

Adcock, I. M. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707166 · Cited by 217 · see citing works