Cited by 45Redox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative MechanismsRheumatoid Arthritis Research and Therapies

Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes

Open access
Szabó-Taylor, Katalin É., Eggleton, Paul, Turner, Carly A.L., Faro, M. Letizia Lo, Tarr, Joanna M., Tóth, Sára, Whiteman, Matt, Haigh, Richard C. +2 more·2012·The International Journal of Biochemistry & Cell Biology

Abstract

Peroxiredoxin 2 has immune regulatory functions, but its expression in human peripheral blood lymphocytes and levels in extracellular fluid in healthy subjects and rheumatoid arthritis patients are poorly described. In the present study, the median intracellular peroxiredoxin 2 protein content of lymphocytes from rheumatoid arthritis patients was more than two-fold higher compared with healthy subjects' lymphocytes. Intracellular peroxiredoxin 3 levels were similar in healthy and rheumatoid arthritis lymphocytes. Flow cytometry detected peroxiredoxin 2 on the surface of ca. 8% of T cells and ca. 56% of B cells (median % values) of all subjects analyzed. Exofacial thioredoxin-1 was also observed. In the total lymphocyte population from rheumatoid arthritis patients, few cells (median, 6%) displayed surface peroxiredoxin 2. In contrast, a significantly increased proportion of interleukin-17(+ve) lymphocytes were exofacially peroxiredoxin 2(+ve) (median, 39%). Prdx2 was also detected in human extracellular fluids. We suggest that crucial inflammatory cell subsets, i.e. interleukin-17(+ve) T cells, exhibit increased exofacial redox-regulating enzymes and that peroxiredoxin 2 may be involved in the persistence of pro-inflammatory cells in chronic inflammation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.biocel.2012.04.016

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Peroxiredoxin 2 has been found to be secreted by inflammatory cells and is elevated in synovial fluids and serum in patients with rheumatoid arthritis.

    “PRX2 has been found to be secreted by inflammatory cells and is elevated in synovial fluids and serum in patients with rheumatoid arthritis (Szabo-Taylor et al. 2012).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Lehtonen S.T. Svensk A.M. Soini Y. Pääkkö P. Hirvikoski P. Kang S.W. A novel protein family in lung cancer International Journal of Cancer 111 2004 514 521 15239128

Cited by

Sorted by citations

Authors
Szabó-Taylor, K. É., Eggleton, P., Turner, C. A. L., Faro, M. L. L., Tarr, J. M., Tóth, S., Whiteman, M., Haigh, R. C., Littlechild, J. A., & Winyard, P. G.
Affiliations
  • Semmelweis University (HU)
  • University of Exeter (GB)
Corresponding author
Winyard, Paul G.
Venue
The International Journal of Biochemistry & Cell Biology
Publisher
Elsevier BV
Published
2012-08
Volume
44
Issue
8
Pages
1223-1231
ISSN
1357-2725 (ISSN-L)
OpenAlex
W2075658381
Cited by
45
References
54
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 2
FWCI
1.80
Type
journal article
Language
en
Open access
Locations
  • The International Journal of Biochemistry & Cell Biology (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Northcott Devon Medical Foundation
  • Peninsula Medical School
  • European Union FP7 Marie Curie ITN program (215009)
  • Arthritis Research UK (17231)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords
peroxiredoxin 2, rheumatoid arthritis, peripheral blood lymphocytes, thioredoxin-1, peroxiredoxin 3, redox regulation, chronic inflammation, B cells, T cells
MeSH terms
Adult, Aged, Arthritis, Rheumatoid, B-Lymphocytes, Female, Flow Cytometry, Humans, Intracellular Fluid, Lymphocytes, Male, Middle Aged, Oxidation-Reduction, T-Lymphocytes, Thioredoxins, Blotting, Western, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-17, Extracellular Fluid, Peroxiredoxins, Peroxiredoxin III

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review