Type 17 T helper cells-origins, features and possible roles in rheumatic disease.

Annunziato, Francesco; Cosmi, Lorenzo; Liotta, Francesco; Maggi, Enrico; Romagnani, Sergio

doi:10.1038/nrrheum.2009.80

Cited by 212Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyRheumatoid Arthritis Research and Therapies

Type 17 T helper cells-origins, features and possible roles in rheumatic disease.

Annunziato, Francesco, Cosmi, Lorenzo, Liotta, Francesco, Maggi, Enrico, Romagnani, Sergio·2009·Nature Reviews Rheumatology

DOI 10.1038/nrrheum.2009.80

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Abstract

Type 17 T helper (TH17) cells are a population of CD4+ effector T cells that are distinct from TH1 and TH2 cells owing to their ability to produce interleukin (IL)-17. Although TH1 and TH2 cells are similar in mice and humans, TH17 cells differ in several ways. The differentiation of mouse TH17 cells requires transforming growth factor beta and IL-6, whereas human naive T cells can develop into TH17 cells in the presence of IL-1beta and IL-23 alone, transforming growth factor beta having an indirect role in their development via the selective inhibition of TH1 cell expansion. in both mice and humans, a late developmental plasticity of TH17 cells towards the TH1 lineage has been shown. Mainly based on mouse gene knockout studies, TH17 lymphocytes have been found to have a pathogenic role in several autoimmune disorders; however, whether human autoimmune disorders, including rheumatoid arthritis (RA) and psoriasis, are prevalently TH1-mediated or TH17-mediated, is still unclear. research suggests that both TH1 and TH17 cells are involved in RA pathogenesis, raising the possibility that interventions that target both the IL-23-IL-17 (TH17) and the IL-12-interferon gamma (TH1) axes might be successful future therapeutic approaches for RA.

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TH1 and TH17 cells are key drivers of pathogenic immunity in RA.
“TH1 and TH17 cells have been identified as key drivers of the pathogenic immunity in RA [38,39].”
From T-cell aging in rheumatoid arthritis (2014) · cites this paper as [39]

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,438 · see citing works
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087 · see citing works
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works
Development, cytokine profile and function of human interleukin 17-producing helper T cells
Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Y., Danilenko, D., Valdez, P., Kasman, I., Eastham-Anderson, J., Wu, J., & Ouyang, W. (2007) · Nature · doi:10.1038/nature05505 · Cited by 2,034 · see citing works
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
Leonardi, C. L., Kimball, A. B., Papp, K. A., Yeilding, N. M., Guzzo, C. A., Wang, Y., Li, S., Dooley, L. T., & Gordon, K. B. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60725-4 · Cited by 1,870 · see citing works
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861 · see citing works
Self-citation
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
Ouyang, W., Kolls, J. K., & Zheng, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.004 · Cited by 1,698 · see citing works
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669 · see citing works
T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.016 · Cited by 1,605 · see citing works
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K., & Iwakura, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.566 · Cited by 1,536 · see citing works
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 1× · see citing works
“In RA, IL-17 certainly contributes to neutrophil recruitment in the synovium owing to its ability to induce IL-6 and IL-8 production by fibroblasts, endothelial and epithelial cells”
Background
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
Papp, K. A., Langley, R. G. B., Lebwohl, M., Krueger, G. G., Szapary, P. O., Yeilding, N. M., Guzzo, C. A., Hsu, M.-C., Wang, Y., Li, S., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60726-6 · Cited by 1,358 · see citing works
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
Manel, N., Unutmaz, D., & Littman, D. R. (2008) · Nature Immunology · doi:10.1038/ni.1610 · Cited by 1,284 · see citing works
Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice
Nakae, S., Nambu, A., Sudo, K., & Iwakura, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6173 · Cited by 1,272 · see citing works
THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses
Gately, M. K., Renzetti, L. M., Magram, J., STERN, A. S., Adorini, L., Gubler, U., & Presky, D. H. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.495 · Cited by 1,231 · see citing works
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157 · see citing works
Human TH1 and TH2 subsets: doubt no more
Romagnani, S. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90120-i · Cited by 1,096 · see citing works
Self-citation
The Th1/Th2 paradigm
Romagnani, S. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)80019-9 · Cited by 1,063 · see citing works
Self-citation
Late Developmental Plasticity in the T Helper 17 Lineage
Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.005 · Cited by 1,053 · see citing works
Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A.-M., Painter, S. L., Comeau, M. R., Cohen, J. I., & Spriggs, M. K. (1995) · Immunity · doi:10.1016/1074-7613(95)90070-5 · Cited by 995 · see citing works
A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses
Volpe, E., Servant, N., Zollinger, R., Bogiatzi, S. I., Hupé, P., Barillot, E., & Soumelis, V. (2008) · Nature Immunology · doi:10.1038/ni.1613 · Cited by 938 · see citing works
IL-21 and TGF-β are required for differentiation of human TH17 cells
Yang, L., Anderson, D. E., Baecher‐Allan, C., Hastings, W. D., Bettelli, E., Oukka, M., Kuchroo, V. K., & Hafler, D. A. (2008) · Nature · doi:10.1038/nature07021 · Cited by 926 · see citing works
Serum Levels of TNF‐α, IFN‐γ, IL‐6, IL‐8,IL‐12, IL‐17, and IL‐18 in Patients With Active Psoriasis andCorrelation With Disease Severity
Arican, O., Aral, M., Sasmaz, S., & Ciragil, P. (2005) · Mediators of Inflammation · doi:10.1155/mi.2005.273 · Cited by 805 · see citing works
Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22
Takatori, H., Kanno, Y., Watford, W. T., Tato, C. M., Weiss, G. E., Ivanov, I. I., Littman, D. R., & O’Shea, J. J. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072713 · Cited by 737 · see citing works
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells
Koenen, H. J. P. M., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. H., & Joosten, I. (2008) · Blood · doi:10.1182/blood-2008-01-133967 · Cited by 735 · see citing works
Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β
Xu, L., Kitani, A., Fuss, I. J., & Strober, W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6725 · Cited by 733 · see citing works
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
Luger, D., Silver, P. B., Tang, J., Cua, D., Chen, Z., Iwakura, Y., Bowman, E. P., Sgambellone, N. M., Chan, C., & Caspi, R. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071258 · Cited by 721 · see citing works
Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor
Cosmi, L., Palma, R. D., Santarlasci, V., Maggi, L., Capone, M., Frosali, F., Rodolico, G., Querci, V., Abbate, G., Angeli, R., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080397 · Cited by 708 · see citing works
Self-citation
Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
Zaba, L. C., Cardinale, I. R., Gilleaudeau, P., Sullivan-Whalen, M. M., Suárez‐Fariñas, M., Fuentes‐Duculan, J., Novitskaya, I., Khatcherian, A., Bluth, M. J., Lowes, M. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071094 · Cited by 676 · see citing works
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
Ma, C. S., Chew, G. Y. J., Simpson, N., Priyadarshi, A., Wong, M., Grimbacher, B., Fulcher, D. A., Tangye, S. G., & Cook, M. C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080218 · Cited by 652 · see citing works
IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
Kroenke, M. A., Carlson, T. J., Andjelkovic, A. V., & Segal, B. M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080159 · Cited by 580 · see citing works
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice
Bending, D., Peña, H. D. L., Veldhoen, M., Phillips, J. M., Uyttenhove, C., Stockinger, B., & Cooke, A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37865 · Cited by 559 · see citing works
Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells
Mathur, A. N., Chang, H., Zisoulis, D. G., Stritesky, G. L., Yu, Q., O’Malley, J. T., Kapur, R., Levy, D. E., Kansas, G. S., & Kaplan, M. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4901 · Cited by 548 · see citing works
Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
Veldhoen, M., Hirota, K., Christensen, J. R., O’Garra, A., & Stockinger, B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081438 · Cited by 522 · see citing works
Stimulation of the Intracellular Bacterial Sensor NOD2 Programs Dendritic Cells to Promote Interleukin-17 Production in Human Memory T Cells
van Beelen, A. J., Zelinková, Z., Taanman-Kueter, E. W., Muller, F. J. M., Hommes, D. W., Zaat, S. A. J., Kapsenberg, M. L., & de Jong, E. C. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.013 · Cited by 516 · see citing works
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
Ogawa, A., Andoh, A., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Clinical Immunology · doi:10.1016/j.clim.2003.09.013 · Cited by 495 · see citing works
IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
Nakae, S., Saijo, S., Horai, R., Sudo, K., Mori, S., & Iwakura, Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1035999100 · Cited by 490 · see citing works
IL-17–producing human peripheral regulatory T cells retain suppressive function
Bériou, G., Costantino, C. M., Ashley, C. W., Yang, L., Kuchroo, V. K., Baecher‐Allan, C., & Hafler, D. A. (2009) · Blood · doi:10.1182/blood-2008-10-183251 · Cited by 482 · see citing works
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
Hirota, K., Hashimoto, M., Yoshitomi, H., Tanaka, S., Nomura, T., Yamaguchi, T., Iwakura, Y., Sakaguchi, N., & Sakaguchi, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062259 · Cited by 475 · see citing works
In Vitro and In Situ Expression of IL-23 by Keratinocytes in Healthy Skin and Psoriasis Lesions: Enhanced Expression in Psoriatic Skin
Pişkin, G., Sylva-Steenland, R. M. R., Bos, J. D., & Teunissen, M. B. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1908 · Cited by 455 · see citing works
Mutations in STAT3 and IL12RB1 impair the development of human IL-17–producing T cells
de Beaucoudrey, L., Puel, A., Filipe‐Santos, O., Cobat, A., Ghandil, P., Chrabieh, M., Feinberg, J. M., von Bernuth, H., Samarina, A., Jannière, L., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080321 · Cited by 438 · see citing works
Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
Hofstetter, H. H., Ibrahim, S. M., Koczan, D., Kruse, N., Weishaupt, A., Toyka, K. V., & Gold, R. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2005.11.002 · Cited by 418 · see citing works
IL-17 Is Produced by Some Proinflammatory Th1/Th0 Cells But Not by Th2 Cells
Aarvak, T., Chabaud, M., Miossec, P., & Natvig, J. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1246 · Cited by 410 · see citing works
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
Capon, F., Meglio, P. D., Szaub, J., Prescott, N. J., Dunster, C., Southgate, L., Timms, K. M., Gutin, A., Abkevich, V., Burden, A. D., et al. (2007) · Human Genetics · doi:10.1007/s00439-007-0397-0 · Cited by 406 · see citing works
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
Martín‐Orozco, N., Chung, Y., Chang, S. H., Wang, Y., & Dong, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200838475 · Cited by 359 · see citing works
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
Sato, K., Suematsu, A., Nakashima, T., Takemoto‐Kimura, S., Aoki, K., Morishita, Y., Asahara, H., Ohya, K., Yamaguchi, A., Takai, T., et al. (2006) · Nature Medicine · doi:10.1038/nm1515 · Cited by 347 · see citing works
Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: A two‐year prospective study (the DAMAGE study cohort)
Kirkham, B. W., Lassere, M. N., Edmonds, J. P., Juhasz, K. M., Bird, P. A., Lee, C. S., Shnier, R., & Portek, I. J. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21749 · Cited by 336 · see citing works
Both IL-12p70 and IL-23 are synthesized during active Crohnʼs disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
Fuss, I. J., Becker, C., Yang, Z., Groden, C. A., Hornung, R. L., Heller, F., Neurath, M. F., Strober, W., & Mannon, P. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000194183.92671.b6 · Cited by 322 · see citing works
Lower limb enthesopathy in patients with psoriasis without clinical signs of arthropathy: a hospital-based case–control study
Gisondi, P., Tinazzi, I., El-Dalati, G., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.075101 · Cited by 304 · see citing works
IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis?
Lubberts, E. (2008) · Cytokine · doi:10.1016/j.cyto.2007.09.014 · Cited by 289 · see citing works
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
Huber, M., Brüstle, A., Reinhard, K., Guralnik, A., Walter, G. J., Mahiny, A. J., von Löw, E., & Lohoff, M. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809077106 · Cited by 281 · see citing works
Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis
Nair, R. P., Ruether, A., Stuart, P. E., Jenisch, S., Tejasvi, T., Hiremagalore, R., Schreiber, S., Kabelitz, D., Lim, H. W., Voorhees, J. J., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701255 · Cited by 277 · see citing works
Blockade of the interleukin‐21/interleukin‐21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
Young, D. A., Hegen, M., Margery, H. L., Whitters, M. J., Albert, L. M., Lowe, L. D., Senices, M., Wu, P. W., Sibley, B. J., Leathurby, Y., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22452 · Cited by 275 · see citing works
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation
Chen, Z., Laurence, A., & O'Shea, J. J. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.10.015 · Cited by 274 · see citing works
Th17 cytokines and mucosal immunity
Dubin, P. J., & Kolls, J. K. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00703.x · Cited by 262 · see citing works
Interleukin‐35: odd one out or part of the family?
Collison, L. W., & Vignali, D. A. A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00704.x · Cited by 262 · see citing works
Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes
Evans, H. G., Suddason, T., Jackson, I., Taams, L. S., & Lord, G. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708426104 · Cited by 254 · see citing works
Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin‐17 receptor IgG1 Fc fusion protein
Bush, K., Farmer, K. M., Walker, J. S., & Kirkham, B. W. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10173 · Cited by 251 · see citing works
Proinflammatory role of the Th17 cytokine interleukin‐22 in collagen‐induced arthritis in C57BL/6 mice
Geboes, L., Dumoutier, L., Kelchtermans, H., Schurgers, E., Mitera, T., Renauld, J., & Matthys, P. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24220 · Cited by 235 · see citing works
Interleukin‐6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses
Fujimoto, M., Serada, S., Mihara, M., Uchiyama, Y., Yoshida, H., Koike, N., Ohsugi, Y., Nishikawa, T., Ripley, B., Kimura, A., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24126 · Cited by 225 · see citing works
Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
Notley, C. A., Inglis, J. J., Alzabin, S., McCann, F. E., McNamee, K., & Williams, R. O. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072707 · Cited by 196 · see citing works
Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy.
Singh, R., Aggarwal, A., & Misra, R. (2007) · PubMed · Cited by 160 · see citing works
Treatment with gamma‐interferon triggers the onset of collagen arthritis in mice
Mauritz, N. J., Holmdahl, R., Jonsson, R., van der Meide, P. H., Scheynius, A., & Klareskog, L. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780311012 · Cited by 157 · see citing works
TGF‐β indirectly favors the development of human Th17 cells by inhibiting Th1 cells
Santarlasci, V., Maggi, L., Capone, M., Frosali, F., Querci, V., Palma, R. D., Liotta, F., Cosmi, L., Maggi, E., Romagnani, S., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200838748 · Cited by 157 · see citing works
Self-citation
Phenotype Switching by Inflammation-Inducing Polarized Th17 Cells, but Not by Th1 Cells
Shi, G., Cox, C. A., Vistica, B. P., Tan, C., Wawrousek, E. F., & Gery, I. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7205 · Cited by 156 · see citing works
Th17 cells in immunity and autoimmunity
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Authors: Annunziato, F., Cosmi, L., Liotta, F., Maggi, E., & Romagnani, S.
Affiliations: University of Florence (IT)
Corresponding author: Romagnani, Sergio
ORCID: Annunziato, Francesco
Cosmi, Lorenzo
Liotta, Francesco
Maggi, Enrico
Venue: Nature Reviews Rheumatology
Publisher: Springer Science and Business Media LLC
Published: 2009-05-12
Volume: 5
Issue: 6
Pages: 325-331
ISSN: 1759-4790 (ISSN-L)
1759-4804
DOI: 10.1038/nrrheum.2009.80
OpenAlex: W2028839726
Cited by: 212
References: 80
Citations by year: 2025: 4 · 2024: 2 · 2023: 4 · 2021: 7 · 2020: 4 · 2019: 9 · 2018: 14 · 2017: 10 · 2016: 15 · 2015: 20 · 2014: 15 · 2013: 20 · 2012: 15
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Rheumatology (publishedVersion)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion)
Funders: Ministero della Salute
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: Th17 cells, IL-17, rheumatic diseases, rheumatoid arthritis, psoriasis, autoimmune disease pathogenesis, Th1 cells, Th17 cell differentiation, IL-23, IL-12, interferon-gamma, T cell plasticity, CD4+ T cells
MeSH terms: Animals, Humans, Rheumatic Diseases, T-Lymphocyte Subsets, Interleukin-17

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Type 17 T helper cells-origins, features and possible roles in rheumatic disease.

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