The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Regulation of muscle protein synthesis and the effects of catabolic states
Open accessAbstract
Protein synthesis and degradation are dynamically regulated processes that act in concert to control the accretion or loss of muscle mass. The present article focuses on the mechanisms involved in the impairment of protein synthesis that are associated with skeletal muscle atrophy. The vast majority of mechanisms known to regulate protein synthesis involve modulation of the initiation phase of mRNA translation, which comprises a series of reactions that result in the binding of initiator methionyl-tRNAi and mRNA to the 40S ribosomal subunit. The function of the proteins involved in both events has been shown to be repressed under atrophic conditions such as sepsis, cachexia, chronic kidney disease, sarcopenia, and disuse atrophy. The basis for the inhibition of protein synthesis under such conditions is likely to be multifactorial and includes insulin/insulin-like growth factor 1 resistance, pro-inflammatory cytokine expression, malnutrition, corticosteroids, and/or physical inactivity. The present article provides an overview of the existing literature regarding mechanisms and signaling pathways involved in the regulation of mRNA translation as they apply to skeletal muscle wasting, as well as the efficacy of potential clinical interventions such as nutrition and exercise in the maintenance of skeletal muscle protein synthesis under atrophic conditions.
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“Instead, amino acids promote the assembly of a mTORC1 complex with the Rag small GTPases and a heteropentameric complex referred to as Ragulator at the late endosomal/lysosomal membrane (Sancak et al., 2010).”
BackgroundRheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
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“As noted above, impaired insulin and Akt signaling to mTORC1 may be a consequence of concomitant activation of AMPK.”
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Amino acid ingestion improves muscle protein synthesis in the young and elderly
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BackgroundMonocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation
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Background
Cited by
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich, O., Reid, M. B., Van den Berghe, G., Vanhorebeek, I., Hermans, G., Rich, M. M., & Larsson, L. (2015) · Physiological Reviews · doi:10.1152/physrev.00028.2014 · Cited by 396
Protein Consumption and the Elderly: What Is the Optimal Level of Intake?
Baum, J., Kim, I.-Y., & Wolfe, R. (2016) · Nutrients · doi:10.3390/nu8060359 · Cited by 312
Ribosome biogenesis: Emerging evidence for a central role in the regulation of skeletal muscle mass
Chaillou, T., Kirby, T. J., & McCarthy, J. J. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24604 · Cited by 211
The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size
Watt, K. I., Turner, B. J., Hagg, A., Zhang, X., Davey, J. R., Qian, H., Beyer, C., Winbanks, C. E., Harvey, K. F., & Gregorevic, P. (2015) · Nature Communications · doi:10.1038/ncomms7048 · Cited by 164
Rivas, D. A., McDonald, D. J., Rice, N. P., Haran, P. H., Dolnikowski, G. G., & Fielding, R. A. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00198.2015 · Cited by 132
Metadata
- Authors
- Gordon, B. S., Kelleher, A. R., & Kimball, S. R.
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 45
- Issue
- 10
- Pages
- 2147-2157
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W2029296519
- Cited by
- 208
- References
- 28
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Gordon, B. S., Kelleher, A. R., & Kimball, S. R. (2013). Regulation of muscle protein synthesis and the effects of catabolic states. The International Journal of Biochemistry & Cell Biology. https://doi.org/10.1016/j.biocel.2013.05.039
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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