The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size
Open accessAbstract
The Yes-associated protein (YAP) is a core effector of the Hippo pathway, which regulates proliferation and apoptosis in organ development. YAP function has been extensively characterized in epithelial cells and tissues, but its function in adult skeletal muscle remains poorly defined. Here we show that YAP positively regulates basal skeletal muscle mass and protein synthesis. Mechanistically, we show that YAP regulates muscle mass via interaction with TEAD transcription factors. Furthermore, YAP abundance and activity in muscles is increased following injury or degeneration of motor nerves, as a process to mitigate neurogenic muscle atrophy. Our findings highlight an essential role for YAP as a positive regulator of skeletal muscle size. Further investigation of interventions that promote YAP activity in skeletal muscle might aid the development of therapeutics to combat muscle wasting and neuromuscular disorders. The Yes-associated protein (YAP) is a core effector of the Hippo pathway, which regulates proliferation and apoptosis in organ development, but its function in adult skeletal muscle remains poorly defined. Here the authors show that YAP is an essential regulator of myofibre size in adult skeletal muscle, via interaction with TEAD transcription factors.
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Nuclear deformation can affect pore dynamics, chromatin organization, and intranuclear trafficking of mechanosensitive regulators.
“Experimental studies indicate that nuclear deformation can affect pore dynamics, chromatin organization, and the intranuclear trafficking of mechanosensitive regulators [204,205,206].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [205]
The Discussion (page unavailable) reports increased nuclear accumulation of YAP after disruption of the neuromuscular junction, supporting a change in a regulator’s nuclear localization. It does not show that nuclear deformation caused that change, or address pore dynamics or chromatin organization; the mechanisms linking mechanical cues to YAP signaling are described as a subject for future investigation. (LLM, conf=0.86)
Experimental — accuracy not yet measuredYap in muscle fibres promotes skeletal muscle hypertrophy.
“whereas Yap in 45 muscle fibres and cardiomyocytes promotes skeletal muscle hypertrophy and cardiomyocyte 46 adaptations, respectively.”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [148]
Increased Yap activity can promote muscle hypertrophy.
“Given that increased Yap activity can promote muscle hypertrophy (46, 148)”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [148]
Overexpressing the predominant YAP isoform in mouse muscle via rAAV6 increased muscle mass, cross-sectional area, and protein synthesis.
“Additionally, they used the same rAAV6 system to over express the predominant YAP isoform in muscle and found increases in muscle mass, cross sectional area and protein synthesis (Table 1, (148)).”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [148]
Experimental — accuracy not yet measuredReducing Yap levels in mouse limb muscles via rAAV6-mediated shRNA decreased muscle fibre size and protein synthesis.
“They found a decreased muscle fibre size and reduced protein synthesis (148).”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [148]
YAP interventions in mouse muscle did not appear to affect mTOR activity.
“Intriguingly, despite the extensive evidence of cross-talk between Hippo and mTOR signalling discussed in the first part of this review, their YAP interventions did not seem to affect mTOR activity.”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [148]
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- Authors
- Watt, K. I., Turner, B. J., Hagg, A., Zhang, X., Davey, J. R., Qian, H., Beyer, C., Winbanks, C. E., Harvey, K. F., & Gregorevic, P.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- The University of Melbourne (AU)
- Corresponding author
- Gregorevic, P.
- Venue
- Nature Communications
- Published
- 2015-01-12
- Volume
- 6
- Issue
- 1
- Pages
- 6048-6048
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2001714642
- Cited by
- 164
- References
- 46
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 12 · 2023: 28 · 2022: 15 · 2021: 19 · 2020: 11 · 2019: 16 · 2018: 12 · 2017: 11 · 2016: 7 · 2015: 4
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- Monash University Research Portal (Monash University) (acceptedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Pfizer
- Motor Neurone Disease Research Institute of Australia
- Pfizer Australia
- State Government of Victoria
- Medical Research Council
- National Health and Medical Research Council (1046782, 1009995)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- YAP, Hippo signaling pathway, muscle mass, TEAD transcription factors, muscle protein synthesis, neurogenic atrophy, motor nerve injury, muscle degeneration, muscle atrophy, neuromuscular disorders
- MeSH terms
- Hippo Signaling Pathway, YAP-Signaling Proteins, Animals, Denervation, Female, Humans, Hypertrophy, Male, Mice, Inbred C57BL, Muscular Atrophy, Nerve Degeneration, Organ Size, Phosphoproteins, RNA, Messenger, Transcription Factors, Blotting, Western, Signal Transduction, Up-Regulation, Protein Serine-Threonine Kinases, Muscle Fibers, Skeletal, Cell Cycle Proteins, Adaptor Proteins, Signal Transducing, HEK293 Cells
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