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Cited by 56Autism Spectrum Disorder ResearchCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Plasma Oxysterol Profiling in Children Reveals 24-Hydroxycholesterol as a Potential Marker for Autism Spectrum Disorders

Grayaa, S., Zerbinati, C., Messedi, M., HadjKacem, I., Chtourou, M., Ben Touhemi, D., Naifar, M., Ayadi, H. +2 more·2018·Biochimie
DOI 10.1016/j.biochi.2018.04.026
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Abstract

Cholesterol and its oxygenated metabolites, such as oxysterols, are intensively investigated as potential players in the pathophysiology of brain disorder. Altered oxysterol levels have been described in patients with numerous neuropsychiatric disorders, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Parkinson's disease, X-linked adrenoleukodystrophy, and Smith-Lemli-Opitz Syndrome. Recent studies have shown that Autism Spectrum Disorders are associated with disruption of cholesterol metabolism. The present study aimed at investigating the profile of oxysterols in plasma and their association with clinical parameters in patients with Autism Spectrum Disorders. Thirty-six children with Autism Spectrum Disorders and thirty-eight healthy children, from Sfax (a southern area of Tunisia) matched for age and sex, were included in the study. The severity of Autism Spectrum Disorders was evaluated using the childhood autism rating scale. Standard lipid profile (total cholesterol, triglycerides, and high-density lipoprotein-cholesterol), serum glucose, high-sensitive C-reactive protein and orosomucoid levels were measured utilizing standard techniques. Oxysterol levels were measured by isotope-dilution gas chromatography/mass spectrometry. Standard lipid profile, serum glucose, high-sensitive C-reactive protein and orosomucoid levels were similar between the two studied populations. Compared to the control group, children with Autism Spectrum Disorders showed a signific…

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  • Modulation of CYP46A1 has been indirectly demonstrated in autistic children, who showed higher plasma 24 HC levels, which progressively decreased with age.

    “Interestingly, modulation of CYP46A1 has been indirectly demonstrated in autistic children, who showed higher plasma 24 HC levels, which progressively decreased with age [49].”

    From Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome (2022) · cites this paper as [49]

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Authors
Grayaa, S., Zerbinati, C., Messedi, M., HadjKacem, I., Chtourou, M., Ben Touhemi, D., Naifar, M., Ayadi, H., Ayedi, F., & Iuliano, L.
Affiliations
  • University of Sfax (TN)
  • University of Rome Tor Vergata (IT)
Corresponding author
  • Grayaa, S.
  • Iuliano, L.
ORCID
Venue
Biochimie
Publisher
Elsevier BV
Published
2018-10
Volume
153
Pages
80-85
ISSN
  • 0037-9042 (ISSN-L)
  • 0300-9084
DOI
10.1016/j.biochi.2018.04.026
OpenAlex
W2799612996
Cited by
56
References
3
Citations by year
2026: 5 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 6 · 2021: 12 · 2020: 7 · 2019: 4 · 2018: 1
FWCI
3.57
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biochimie (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
  • Ministry of Higher Education and Scientific Research
  • Ministry of Health
  • University of Rome
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
autism spectrum disorder, oxysterols, 24S-hydroxycholesterol, plasma biomarkers, cholesterol metabolism, 7α-hydroxycholesterol, 25-hydroxycholesterol, diagnostic biomarkers, children, lipid profile, C-reactive protein, alpha-1-acid glycoprotein
MeSH terms
Oxysterols, Autistic Disorder, Child, Child, Preschool, Female, Humans, Hydroxycholesterols, Male, Risk Factors, Biomarkers

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