Can Cholesterol Metabolism Modulation Affect Brain Function and Behavior?

CNS synaptogenesis promoted by glia-derived cholesterol

Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβPreprint

Repa, J. J., Liang, G., Ou, J., Bashmakov, Y. K., Lobaccaro, J. A., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., & Mangelsdorf, D. J. (2000) · Genes & Development · doi:10.1101/gad.844900 · Cited by 1,693 · see citing works

Autism and Abnormal Development of Brain Connectivity: Figure 1.

Belmonte, M. K., Allen, G., Beckel-Mitchener, A., Boulanger, L. M., Carper, R. A., & Webb, S. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3340-04.2004 · Cited by 1,217 · see citing works

Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

Dietschy, J. M., & Turley, S. D. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400004-jlr200 · Cited by 1,095 · see citing works

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

Lütjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Sidén, A., Diczfalusy, U., & Björkhem, I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9799 · Cited by 682 · see citing works

Statin Adverse Effects: A Review of the Literature and Evidence for a Mitochondrial Mechanism

Golomb, B. A., & Evans, M. A. (2008) · American Journal of Cardiovascular Drugs · doi:10.2165/0129784-200808060-00004 · Cited by 677 · see citing works

Autism spectrum disorders-a genetics review

Miles, J. H. (2011) · Genetics in Medicine · doi:10.1097/gim.0b013e3181ff67ba · Cited by 567 · see citing works

A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls

Goff, D. C., Sullivan, L. M., McEvoy, J. P., Meyer, J. M., Nasrallah, H. A., Daumit, G. L., Lamberti, S., D'Agostino, R. B., Stroup, T. S., Davis, S., et al. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.08.010 · Cited by 528 · see citing works

Serotonin selectively influences moral judgment and behavior through effects on harm aversion

Crockett, M. J., Clark, L., Hauser, M. D., & Robbins, T. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009396107 · Cited by 526 · see citing works

Changes in Glucose and Cholesterol Levels in Patients With Schizophrenia Treated With Typical or Atypical Antipsychotics

Lindenmayer, J., Czobor, P., Volavka, J., Citrome, L., Sheitman, B., McEvoy, J. P., Cooper, T. B., Chakos, M., & Lieberman, J. A. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.290 · Cited by 465 · see citing works

The role of cholesterol in membrane fusion

Yang, S.-T., Kreutzberger, A. J. B., Lee, J., Kiessling, V., & Tamm, L. K. (2016) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2016.05.003 · Cited by 421 · see citing works

Central nervous system: cholesterol turnover, brain development and neurodegeneration

Dietschy, J. M. (2009) · bchm · doi:10.1515/bc.2009.035 · Cited by 394 · see citing works

Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

Wolozin, B. L., Wang, S. W., Li, N.-C., Lee, A. F., Lee, T. A., & Kazis, L. E. (2007) · BMC Medicine · doi:10.1186/1741-7015-5-20 · Cited by 385 · see citing works

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization

Bosco, D. A., Fowler, D. M., Zhang, Q., Nieva, J. J., Powers, E. T., Wentworth, P., Lerner, R. A., & Kelly, J. W. (2006) · Nature Chemical Biology · doi:10.1038/nchembio782 · Cited by 349 · see citing works

Serotonin Uptake Sites and Serotonin Receptors Are Altered in the Limbic System of Schizophrenics

Joyce, J. N., Shane, A. L., Lexow, N., Winokur, A., Casanova, M. F., & Kleinman, J. E. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.32 · Cited by 340 · see citing works

Role of cholesterol in synapse formation and function

Pfrieger, F. W. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00024-5 · Cited by 325 · see citing works

Serum cholesterol changes after midlife and late-life cognition

Solomon, A., Kåreholt, I., Ngandu, T., Winblad, B. G., Nissinen, A. M., Tuomilehto, J. O., Soininen, H. S., & Kivipelto, M. (2007) · Neurology · doi:10.1212/01.wnl.0000256368.57375.b7 · Cited by 311 · see citing works

Outsourcing in the brain: Do neurons depend on cholesterol delivery by astrocytes?

Pfrieger, F. W. (2003) · BioEssays · doi:10.1002/bies.10195 · Cited by 308 · see citing works

Cholesterol in brain disease: Sometimes determinant and frequently implicated

Martín, M. G., Pfrieger, F., & Dotti, C. G. (2014) · The EMBO Reports · doi:10.15252/embr.201439225 · Cited by 304 · see citing works

Importance of a Novel Oxidative Mechanism for Elimination of Brain Cholesterol

Björkhem, I., Lütjohann, D., Breuer, O., Sakinis, A., & Wennmalm, Å. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30178 · Cited by 281 · see citing works

The Cholesterol Quartet

Goldstein, J. L., & Brown, M. S. (2001) · Science · doi:10.1126/science.1061815 · Cited by 242 · see citing works

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

Buchovecky, C. M., Turley, S. D., Brown, H. M., Kyle, S. M., McDonald, J. G., Liu, B., Pieper, A. A., Huang, W., Katz, D. M., Russell, D. W., et al. (2013) · Nature Genetics · doi:10.1038/ng.2714 · Cited by 234 · cited 2× · see citing works

Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome

Osterweil, E. K., Chuang, S.-C., Chubykin, A. A., Sidorov, M., Bianchi, R., Wong, R. K. S., & Bear, M. F. (2013) · Neuron · doi:10.1016/j.neuron.2012.01.034 · Cited by 230 · see citing works

Allelic variation in 5-HT 1A receptor expression is associated with anxiety- and depression-related personality traits

Strobel, A., Gutknecht, L., Rothe, C., Reif, A., M�ssner, R., Zeng, Y., Brocke, B., & Lesch, K. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-003-0072-0 · Cited by 228 · see citing works

Alterations in the serotonin system in schizophrenia: A systematic review and meta-analysis of postmortem and molecular imaging studies

Selvaraj, S., Arnone, D., Cappai, A., & Howes, O. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.06.005 · Cited by 223 · see citing works

Low brain serotonin turnover rate (low CSF 5-HIAA) and impulsive violence.

Virkkunen, M., Goldman, D. A., Nielsen, D. A., & Linnoila, M. (1995) · PubMed Central · Cited by 211 · see citing works

Total cholesterol and the risk of Parkinson disease

Hu, G., Antikaínen, R., Jousilahti, P., Kivipelto, M., & Tuomilehto, J. (2008) · Neurology · doi:10.1212/01.wnl.0000312511.62699.a8 · Cited by 205 · see citing works

Serum Cholesterol Levels and the Risk of Parkinson's Disease

de Lau, L. M. L., Koudstaal, P. J., Albert Hofman, D., & Breteler, M. M. B. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj283 · Cited by 205 · see citing works

Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia

Jow, G., Yang, T., & Chen, C.-L. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.09.015 · Cited by 200 · see citing works

Familial Aggregation of Suicidal Behavior: A Family Study of Male Suicide Completers From the General Population

Kim, C. D., Seguin, M., Therrien, N., Riopel, G., Chawky, N., Lesage, A. D., & Turecki, G. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.5.1017 · Cited by 178 · see citing works

Ontogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse

Quan, G., Xie, C., Dietschy, J. M., & Turley, S. D. (2003) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.09.015 · Cited by 177 · see citing works

Reduction in Levels of 24S-Hydroxycholesterol by Statin Treatment in Patients With Alzheimer Disease

Vega, G. L., Weiner, M., Lipton, A. M., von Bergmann, K., Lütjohann, D., Moore, C. B., & Svetlik, D. A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.4.510 · Cited by 172 · see citing works

Statins reduce neuronal α‐synuclein aggregation in in vitro models of Parkinson’s disease

Bar‐On, P., Crews, L. A., Koob, A. O., Mizuno, H., Adame, A., Spencer, B. J., & Masliah, E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05254.x · Cited by 166 · see citing works

Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington's Disease and Is Manifest in Astrocytes

Valenza, M., Leoni, V., Karasinska, J. M., Petricca, L., Fan, J., Carroll, J., Pouladi, M. A., Fossale, E., Nguyen, H. P., Riess, O., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0917-10.2010 · Cited by 166 · see citing works

Abnormalities of cholesterol metabolism in autism spectrum disorders

Tierney, E., Bukelis, I., Thompson, R. E., Ahmed, K., Aneja, A., Kratz, L., & Kelley, R. I. (2006) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30368 · Cited by 163 · see citing works

Membrane Cholesterol Modulates the Outward Facing Conformation of the Dopamine Transporter and Alters Cocaine Binding

Hong, W. C., & Amara, S. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.150565 · Cited by 153 · see citing works

Effects of membrane cholesterol on the sensitivity of the GABAA receptor to GABA in acutely dissociated rat hippocampal neurones

Sooksawate, T., & Simmonds, M. A. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00159-3 · Cited by 153 · see citing works

Chronic Cholesterol Depletion Using Statin Impairs the Function and Dynamics of Human Serotonin1A Receptors

Shrivastava, S. K., Pucadyil, T. J., Paila, Y. D., Ganguly, S., & Chattopadhyay, A. (2010) · Biochemistry · doi:10.1021/bi100276b · Cited by 150 · see citing works

Serum total cholesterol, statins and cognition in non-demented elderly

Solomon, A., Kåreholt, I., Ngandu, T., Wolozin, B., MacDonald, S. W. S., Winblad, B., Nissinen, A., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.09.012 · Cited by 149 · see citing works

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease

Leoni, V., Mariotti, C., Tabrizi, S. J., Valenza, M., Wild, E. J., Henley, S. M. D., Hobbs, N. Z., Mandelli, M. L., Grisoli, M., Björkhem, I., et al. (2008) · Brain · doi:10.1093/brain/awn212 · Cited by 146 · see citing works

Treatment of Smith-Lemli-Opitz syndrome: Results of a multicenter trial

Irons, M., Elias, E. R., Abuelo, D. N., Bull, M. J., Greene, C. L., Johnson, V. P., Keppen, L. D., Schanen, C., Tint, G. S., & Salen, G. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970131)68:3 · Cited by 138 · see citing works

Low serum cholesterol concentration and serotonin metabolism in men

Steegmans, P. H. A., Fekkes, D., Hoes, A. W., Bak, A. A. A., van der Does, E., & Grobbee, D. E. (1996) · BMJ · doi:10.1136/bmj.312.7025.221 · Cited by 133 · see citing works

Emerging roles for cholesterol in Huntington's disease

Valenza, M., & Cattaneo, E. F. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.005 · Cited by 123 · see citing works

Levels of triglycerides, cholesterol, LDL, HDL and glucose in patients with schizophrenia, unipolar depression and bipolar disorder

Wysokiński, A., Strzelecki, D., & Kłoszewska, I. (2015) · Diabetes & Metabolic Syndrome: Clinical Research & Reviews · doi:10.1016/j.dsx.2015.04.004 · Cited by 120 · see citing works

A Meta-Analysis of Early Sustained Response Rates Between Antidepressants and Placebo for the Treatment of Major Depressive Disorder

Papakostas, G. I., Perlis, R. H., Scalia, M. J., Petersen, T., & D, M. F. M. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000195042.62724.76 · Cited by 117 · see citing works

24S-hydroxycholesterol in plasma: A marker of cholesterol turnover in neurodegenerative diseases

Leoni, V., & Caccia, C. (2012) · Biochimie · doi:10.1016/j.biochi.2012.09.025 · Cited by 114 · see citing works

Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies

Koob, A. O., Ubhi, K. K., Paulsson, J. F., Kelly, J. W., Rockenstein, E. M., Mante, M., Adame, A., & Masliah, E. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.11.015 · Cited by 113 · see citing works

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

Eckert, G. P., Hooff, G. P., Talsness, D. M., Igbavboa, U., Volmer, D. A., Müller, W. E., & Wood, W. G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.005 · Cited by 113 · see citing works

Understanding impulsivity in severe depression? A psychometrical contribution

Corruble, E., Benyamina, A., Bayle, F., Falissard, B., & Hardy, P. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00115-5 · Cited by 111 · see citing works

The effects of cholesterol on learning and memory

Schreurs, B. G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.04.010 · Cited by 105 · see citing works

Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts.

Montes, L. G. A., Valles-Sánchez, V., Moreno-Aguilar, J., Chavez-Balderas, R. A., García-Marín, J. A., Sotres, J. F. C., & Hheinze-Martin, G. (2000) · PubMed Central · Cited by 101 · see citing works

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

Kumar, A., Sharma, N., Gupta, A. K., Kalonia, H., & Mishra, J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.050 · Cited by 98 · see citing works

Prospects of Statins in Parkinson Disease

Roy, A., & Pahan, K. (2011) · The Neuroscientist · doi:10.1177/1073858410385006 · Cited by 96 · see citing works

Acute atorvastatin treatment exerts antidepressant-like effect in mice via the l-arginine–nitric oxide–cyclic guanosine monophosphate pathway and increases BDNF levels

Ludka, F. K., Zomkowski, A. D. E., Cunha, M. P., Dal-Cim, T., Zeni, A. L. B., Rodrigues, A. L. S., & Tasca, C. I. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.005 · Cited by 92 · see citing works

Low cholesterol is associated with depression among US household population

Tedders, S. H., Fokong, K., McKenzie, L. E., Wesley, C., Yu, L., & Zhang, J. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.06.045 · Cited by 91 · see citing works

Whole body cholesterol metabolism is impaired in Huntington's disease

Leoni, V., Mariotti, C., Nanetti, L., Salvatore, E., Squitieri, F., Bentivoglio, A. R., del Poggio, M. B., Piacentini, S., Monza, D., Valenza, M., et al. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.025 · Cited by 90 · see citing works

Serum lipids and memory in a population based cohort of middle age women

Henderson, V. W. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.11.1530 · Cited by 90 · see citing works

Autism: The role of cholesterol in treatment

Aneja, A., & Tierney, E. (2008) · International Review of Psychiatry · doi:10.1080/09540260801889062 · Cited by 82 · see citing works

Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients

Wang, R., Ross, C. A., Cai, H., Cong, W., Daimon, C. M., Carlson, O. D., Egan, J. M., Siddiqui, S., Maudsley, S. R., & Martin, B. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00231 · Cited by 75 · see citing works

Membrane cholesterol stabilizes the human serotonin1A receptor

Saxena, R., & Chattopadhyay, A. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.07.032 · Cited by 74 · see citing works

Stereospecific requirement of cholesterol in the function of the serotonin1A receptor

Jafurulla, M., Rao, B. D., Sugunan, S., Ruysschaert, J., Covey, D. F., & Chattopadhyay, A. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.08.015 · Cited by 73 · see citing works

Cholesterol homeostasis failure in the brain: Implications for synaptic dysfunction and cognitive decline

Segatto, M., Leboffe, L., Trapani, L., & Pallottini, V. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140303142902 · Cited by 65 · see citing works

Statin use and risk of Parkinson’s disease: a meta-analysis of observational studies

Undela, K., Gudala, K., Malla, S., & Bansal, D. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6606-3 · Cited by 62 · see citing works

A role for metabolism in Rett syndrome pathogenesis: New clinical findings and potential treatment targets

Justice, M. J., Buchovecky, C. M., Kyle, S. M., & Djukic, A. (2013) · Rare Diseases · doi:10.4161/rdis.27265 · Cited by 61 · see citing works

Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: Implications for Parkinson's disease

Choi, H. J., Lee, S. Y., Cho, Y., No, H., Kim, S. W., & Hwang, O. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.10.011 · Cited by 58 · see citing works

A Metabolic Study of Huntington’s Disease

Nambron, R., Silajdžić, E., Kalliolia, E., Ottolenghi, C., Hindmarsh, P. C., Hill, N. R., Costelloe, S. J., Martin, N. G., Positano, V., Watt, H., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146480 · Cited by 58 · see citing works

Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation

Mans, R. A., McMahon, L. L., & Li, L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.007 · Cited by 58 · see citing works

Chronic vascular risk factors (cholesterol, homocysteine, ethanol) impair spatial memory, decline cholinergic neurons and induce blood–brain barrier leakage in rats in vivo

Ehrlich, D., & Humpel, C. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.07.002 · Cited by 52 · see citing works

Cholesterol-enriched diet affects spatial learning and synaptic function in hippocampal synapses

Dufour, F., Liu, Q.-Y., Gusev, P., Alkon, D. L., & Atzori, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.086 · Cited by 52 · see citing works

Lipid rafts: A signaling platform linking cholesterol metabolism to synaptic deficits in autism spectrum disorders

Wang, H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00104 · Cited by 52 · see citing works

Analysis of the protein network of cholesterol homeostasis in different brain regions: An age and sex dependent perspective

Segatto, M., Di Giovanni, A., Marino, M., & Pallottini, V. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24315 · Cited by 52 · see citing works

Hypercholesterolemia in Asperger syndrome: Independence from lifestyle, obsessive–compulsive behavior, and social anxiety

Dziobek, I., Gold, S. M., Wolf, O. T., & Convit, A. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.02.003 · Cited by 52 · see citing works

Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats

Segatto, M., Manduca, A., Lecis, C., Rosso, P., Jozwiak, A., Swiezewska, E., Moreno, S., Trezza, V., & Pallottini, V. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.284 · Cited by 51 · see citing works

Low cholesterol is a risk factor for attentional impulsivity in patients with mood symptoms

Troisi, A. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.11.005 · Cited by 50 · see citing works

Simvastatin improves learning and memory in control but not in olfactory bulbectomized rats

Douma, T. N., Borre, Y. E., Hendriksen, H., Olivier, B., & Oosting, R. S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2245-0 · Cited by 50 · see citing works

Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-HT1A receptor

Sun, S., Yang, S., Mao, Y., Jia, X., & Zhang, Z. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0020-7 · Cited by 49 · see citing works

Cholesterol and Cognitive Performance in Normal Controls and the Influence of Elective Statin Use after Conversion to Mild Cognitive Impairment: Results in a Clinical Trial Cohort

Sparks, D. L., Kryscio, R. J., Connor, D. J., Sabbagh, M. N., Sparks, L. M., Lin, Y., & Liebsack, C. (2010) · Neurodegenerative Diseases · doi:10.1159/000295660 · Cited by 48 · see citing works

Serum cholesterol concentrations are associated with visuomotor speed in men: findings from the third National Health and Nutrition Examination Survey, 1988–1994

Zhang, J., Muldoon, M. F., & McKeown, R. E. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.291 · Cited by 45 · see citing works

Synergistic Effects of Galantamine and Memantine in Attenuating Scopolamine-Induced Amnesia in Mice

Busquet, P., Capurro, V., Cavalli, A., Piomelli, D., Reggiani, A. M., & Bertorelli, R. (2012) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12166sc · Cited by 44 · see citing works

Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress

Lin, P.-Y., Chang, A. Y. W., & Lin, T.-K. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.06.006 · Cited by 43 · cited 1× · see citing works

Agonist-dependent Signaling by Group I Metabotropic Glutamate Receptors Is Regulated by Association with Lipid Domains

Kumari, R., Castillo, C., & Francesconi, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.475863 · Cited by 42 · see citing works

Age- and sex-related differences in extra-hepatic low-density lipoprotein receptor

Segatto, M., Trapani, L., Marino, M., & Pallottini, V. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22607 · Cited by 37 · see citing works

Age-dependent effect of high cholesterol diets on anxiety-like behavior in elevated plus maze test in rats

Hu, X., Wang, T., Luo, J., Liang, S., Li, W., Wu, X., Jin, F., & Wang, L. (2014) · Behavioral and Brain Functions · doi:10.1186/1744-9081-10-30 · Cited by 35 · see citing works

Regulation of cholesterol biosynthetic pathway in different regions of the rat central nervous system

Segatto, M., Trapani, L., Lecis, C., & Pallottini, V. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02450.x · Cited by 34 · see citing works

Low plasma total cholesterol in patients with Huntington’s disease and first-degree relatives

Markianos, M., Πάνας, Μ., Kalfakis, N., & Vassilopoulos, D. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.10.002 · Cited by 33 · see citing works

Simvastatin Impairs Spatial Memory in Rats at a Specific Dose Level

Baytan, S. H., Alkanat, M., Okuyan, M., Ekіncі, M., Gedikli, E., Özeren, M., & Akgün, A. (2008) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.214.341 · Cited by 33 · see citing works

H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment

Ali-Rahmani, F. G., Grigson, P. S., Lee, S. Y., Neely, E. B., Connor, J. R., & Schengrund, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.014 · Cited by 32 · see citing works

Thrombocyte serotonin and serum cholesterol concentration in suicidal and non-suicidal depressed patients

Ruljančić, N., Mihanović, M., & Čepelak, I. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.02.007 · Cited by 28 · see citing works

Modulation of the Isoprenoid/Cholesterol Biosynthetic Pathway During Neuronal Differentiation In Vitro

Cartocci, V., Segatto, M., Di Tunno, I., Leone, S., Pfrieger, F. W., & Pallottini, V. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25500 · Cited by 28 · see citing works

Atorvastatin evokes a serotonergic system-dependent antidepressant-like effect in mice

Ludka, F. K., Constantino, L. C., Kuminek, G., Binder, L. B., Zomkowski, A. D. E., Cunha, M. P., Dal-Cim, T. A., Rodrigues, A. L. S., & Tasca, C. I. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.04.005 · Cited by 27 · see citing works

Brain Cholesterol Synthesis and Metabolism is Progressively Disturbed in the R6/1 Mouse Model of Huntington’s Disease: A Targeted GC-MS/MS Sterol Analysis

Kreilaus, F., Spiro, A. S., Hannan, A. J., Garner, B., & Jenner, A. M. (2015) · Journal of Huntington s Disease · doi:10.3233/jhd-150170 · Cited by 26 · see citing works

A comparative effect of atorvastatin with other statins in patients of hyperlipidemia

Jose, M., Anandkumar, S., Narmadha, M. P., & Sandeep, M. (2012) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.93864 · Cited by 25 · see citing works

Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks

Micale, V., Scapagnini, G., Colombrita, C., Mazzola, C., Alkon, D. L., & Drago, F. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.11.006 · Cited by 23 · see citing works

Probing extracellular Sonic hedgehog in neurons

Eitan, E., Petralia, R. S., Wang, Y., Indig, F. E., Mattson, M. P., & Yao, P. J. (2016) · Biology Open · doi:10.1242/bio.019422 · Cited by 22 · see citing works

Abnormal cholesterol metabolism in Smith-Lemli-Opitz syndrome

Elias, E. R., & Irons, M. (1995) · The Journal of Pediatrics · doi:10.1097/00008480-199512000-00015 · Cited by 21 · see citing works

Safety and efficacy of combined clozapine–azathioprine treatment in a case of resistant schizophrenia associated with Behçet's disease: a 2-year follow-up

Berardis, D. D., Serroni, N., Campanella, D., Olivieri, L., Marini, S., Moschetta, F. S., Martinotti, G., & Giannantonio, M. D. (2012) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2012.06.007 · Cited by 19 · see citing works

Statins enhance cognitive performance in object location test in albino Swiss mice: Involvement of beta-adrenoceptors

Vandresen-Filho, S., França, L. M., Alcantara-Junior, J., Nogueira, L. C., Brito, T. M., Lopes, L., Júnior, F. M., Vanzeler, M. L. A., Bertoldo, D. B., Dias, P. G., et al. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.024 · Cited by 13 · see citing works

Antisocial Personality Disorder—Stable and Unstable Subtypes

Ullrich, S., & Coid, J. (2010) · Journal of Personality Disorders · doi:10.1521/pedi.2010.24.2.171 · Cited by 12 · see citing works

COMMON THEMES IN PERIPHERAL NEUROPATHY DISEASE GENES

Snipes, G. J., & Orfali, W. (1998) · Cell Biology International · doi:10.1006/cbir.1998.0389 · Cited by 9 · see citing works

First-degree relatives with behavioural adverse effects on statins: Table 1

Reilly, D., Cham, S., & Golomb, B. A. (2011) · BMJ Case Reports · doi:10.1136/bcr.09.2011.4758 · Cited by 6 · see citing works

Further study of blood cholesterol in schizophrenia.

Nadeau, G., & Gh, L. (1952) · PubMed Central · Cited by 5 · see citing works

Human Milk Lipids

Koletzko, B. V. (2016) · Annals of Nutrition and Metabolism · doi:10.1159/000452819 · Cited by 313 · see citing works

Analytical methods for cholesterol quantification

Li, L., Dutkiewicz, E. P., Huang, Y.-C., Zhou, H.-B., & Hsu, C. (2018) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.09.001 · Cited by 161 · see citing works

Statins and the Brain: More than Lipid Lowering Agents?

Fracassi, A., Marangoni, M., Rosso, P., Pallottini, V., Fioramonti, M., Siteni, S., & Segatto, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170703101816 · Cited by 116 · see citing works

Milk polar lipids composition and functionality: a systematic review

Venkat, M., Chia, L. W., & Lambers, T. T. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2104211 · Cited by 79 · see citing works

Cholesterol imbalance and neurotransmission defects in neurodegeneration

Shin, K. C., Moussa, H. Y. A., & Park, Y. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01273-4 · Cited by 81 · see citing works

Morus nigra and its major phenolic, syringic acid, have antidepressant-like and neuroprotective effects in mice

Dalmagro, A. P., Camargo, A., & Zeni, A. L. B. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0089-y · Cited by 68 · see citing works

Plasma Oxysterol Profiling in Children Reveals 24-Hydroxycholesterol as a Potential Marker for Autism Spectrum Disorders

Grayaa, S., Zerbinati, C., Messedi, M., HadjKacem, I., Chtourou, M., Ben Touhemi, D., Naifar, M., Ayadi, H., Ayedi, F., & Iuliano, L. (2018) · Biochimie · doi:10.1016/j.biochi.2018.04.026 · Cited by 56 · see citing works

Altered Brain Cholesterol/Isoprenoid Metabolism in a Rat Model of Autism Spectrum Disorders

Cartocci, V., Catallo, M., Tempestilli, M., Segatto, M., Pfrieger, F. W., Bronzuoli, M. R., Scuderi, C., Servadio, M., Trezza, V., & Pallottini, V. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.053 · Cited by 57 · see citing works

Brain‐derived neurotrophic factor modulates cholesterol homeostasis and Apolipoprotein E synthesis in human cell models of astrocytes and neurons

Spagnuolo, M. S., Donizetti, A., Iannotta, L., Aliperti, V., Cupidi, C., Bruni, A. C., & Cigliano, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26480 · Cited by 52 · see citing works

Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome

Segatto, M., Tonini, C., Pfrieger, F. W., Trezza, V., & Pallottini, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133317 · Cited by 51 · see citing works

Neuroprotective effects of statins against amyloid β-induced neurotoxicity

Huang, C., Li, H., & Lin, C. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.226379 · Cited by 47 · see citing works

Bile Acids in Hepatic Encephalopathy

DeMorrow, S. (2018) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2018.04.011 · Cited by 47 · see citing works

Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition

Emami, A., Shojaei, S., Rosa, S. C. D. S., Aghaei, M., Samiei, E., Vosoughi, A. R., Kalantari, F., Kawalec, P., Thliveris, J. A., Sharma, P. K., et al. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172616 · Cited by 42 · see citing works

Regulation of Synaptic Development by Astrocyte Signaling Factors and Their Emerging Roles in Substance Abuse

Walker, C. D., Risher, W. C., & Risher, M. (2020) · Cells · doi:10.3390/cells9020297 · Cited by 36 · see citing works

FXR-Mediated Cortical Cholesterol Accumulation Contributes to the Pathogenesis of Type A Hepatic Encephalopathy

McMillin, M., Grant, S. M., Frampton, G. A., Petrescu, A. D., Kain, J., Williams, E., Haines, R., Canady, L., & DeMorrow, S. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.02.008 · Cited by 38 · see citing works

Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain

Chen, Y., Yin, M., Cao, X., Hu, G., & Xiao, M. (2018) · Aging and Disease · doi:10.14336/ad.2017.0706 · Cited by 36 · see citing works

Serum lipid profiles and post-stroke depression in acute ischemic stroke patients

Shen, H., Tu, X., Luan, X., Zeng, Y., He, J., & Tang, W. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s204791 · Cited by 33 · see citing works

Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration

Moaddel, R., Zanos, P., Farmer, C., Kadriu, B., Morris, P. J., Lovett, J., Acevedo-Diaz, E. E., Cavanaugh, G. W., Yuan, P., Yavi, M., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01941-x · Cited by 31 · see citing works

The potential role of cholesterol in Parkinson’s disease neuropathology: perpetrator or victim

Alrouji, M., Al-Kuraishy, H. M., Al-Mahammadawy, A.-K. A. A., Al-Gareeb, A. I., Saad, ‏. M., & Batiha, G. E. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06926-2 · Cited by 32 · see citing works

A critical review of bile acids and their receptors in hepatic encephalopathy

Williams, E., Chu, C. S., & DeMorrow, S. (2021) · Analytical Biochemistry · doi:10.1016/j.ab.2021.114436 · Cited by 31 · see citing works

Plasma Lipidomic Analyses in Cohorts With mTBI and/or PTSD Reveal Lipids Differentially Associated With Diagnosis and APOE ε4 Carrier Status

Huguenard, C. J. C., Cseresznye, A., Evans, J. E., Oberlin, S., Langlois, H., Ferguson, S., Darcey, T. S., Nkiliza, A., Dretsch, M. N., MULLAN, M. J., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00012 · Cited by 28 · see citing works

The pharmacological bases for repurposing statins in depression: a review of mechanistic studies

Giorgi, R. D., Pesci, N. R., Rosso, G., Maina, G., Cowen, P. J., & Harmer, C. J. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02533-z · Cited by 29 · see citing works

Requirement of Cholesterol for Calcium‐Dependent Vesicle Fusion by Strengthening Synaptotagmin‐1‐Induced Membrane Bending

Moussa, H. Y. A., Shin, K. C., Ponraj, J., Kim, S. J., Ryu, J., Mansour, S. A., & Park, Y. (2023) · Advanced Science · doi:10.1002/advs.202206823 · Cited by 26 · see citing works

The potential of CYP46A1 as a novel therapeutic target for neurological disorders: An updated review of mechanisms

Alavi, M. S., Karimi, G., Ghanimi, H. A., & Roohbakhsh, A. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175726 · Cited by 25 · see citing works

Maternal Dietary Exposure to Low-Dose Bisphenol A Affects Metabolic and Signaling Pathways in the Brain of Rat Fetuses

Tonini, C., Segatto, M., Gagliardi, S., Bertoli, S., Leone, A., Barberio, L., Mandalà, M., & Pallottini, V. (2020) · Nutrients · doi:10.3390/nu12051448 · Cited by 25 · see citing works

Brain Targeting of Acyl-CoA:Cholesterol O -Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution

Shibuya, K., Morikawa, S., Miyamoto, M., Ogawa, S.-I., Tsunenari, Y., Urano, Y., & Noguchi, N. (2019) · ACS Omega · doi:10.1021/acsomega.9b02307 · Cited by 24 · see citing works

Membrane cholesterol depletion in cortical neurons highlights altered NMDA receptor functionality in a mouse model of amyotrophic lateral sclerosis

Antonini, A., Caioli, S., Saba, L., Vindigni, G., Biocca, S., Canu, N., & Zona, C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.11.008 · Cited by 22 · see citing works

Association between atherogenic index of plasma and post-stroke depression: a cross-sectional study

Kong, D., & Zou, W. (2024) · European Journal of Psychotraumatology · doi:10.1080/20008066.2024.2429266 · Cited by 21 · see citing works

Abnormalities of lipid metabolism in the progression and treatment of depression

Luan, X., Wang, X., Shi, Y., Zhang, X., Wang, Y., Zhou, M., Wu, Z., Liu, Z., Li, X., Zhang, L., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1589663 · Cited by 21 · see citing works

A Short‐Term Western Diet Impairs Cholesterol Homeostasis and Key Players of Beta Amyloid Metabolism in Brain of Middle Aged Rats

Spagnuolo, M. S., Pallottini, V., Mazzoli, A., Iannotta, L., Tonini, C., Morone, B., Ståhlman, M., Crescenzo, R., Strazzullo, M., Iossa, S., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000541 · Cited by 20 · see citing works

Psychological issues and cognitive impairment in adults with familial hypercholesterolemia

Bagnasco, M. S. (2017) · Family Practice · doi:10.1093/fampra/cmx052 · Cited by 17 · see citing works

Mevastatin promotes neuronal survival against Aβ-induced neurotoxicity through AMPK activation

Kornelius, E., Li, H., Peng, C., Hsiao, H., Yang, Y., Huang, C., & Lin, C. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0091-4 · Cited by 17 · see citing works

Macronutrient content and fatty acid composition and their positional distribution in human breast milk from Zhejiang Province, China in different lactation periods

He, G., Li, G., Jiang, Y., Hua, J., Chu, X., Xiong, L., Gong, J., Xiao, G., & Ye, X. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2626 · Cited by 15 · see citing works

Membrane cholesterol removal and replenishment affect rat and monkey brain monoamine transporters

Morissette, M., Morin, N., Rouillard, C., & Paolo, T. D. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.039 · Cited by 14 · see citing works

Neuronal Dysfunction Associated with Cholesterol Deregulation

Marcuzzi, A., Loganes, C., Valencic, E., Piscianz, E., Monasta, L., Bilel, S., Bortul, R., Celeghini, C., Zweyer, M., & Tommasini, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051523 · Cited by 14 · see citing works

Long-lasting impact of perinatal dietary supplementation of omega 3 fatty acids on mevalonate pathway: potential role on neuron trophism in male offspring hippocampal formation

Tonini, C., Schiavi, S., Macca, F., Segatto, M., Trezza, V., & Pallottini, V. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1724452 · Cited by 13 · see citing works

Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks

Roversi, P., Johnson, S., Preston, S. G., Nunn, M. A., Paesen, G. C., Austyn, J. M., Nuttall, P. A., & Lea, S. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16413-2 · Cited by 12 · see citing works

Brain Cholesterol Biosynthetic Pathway Is Altered in a Preclinical Model of Fragile X Syndrome

Parente, M., Tonini, C., Buzzelli, V., Carbone, E., Trezza, V., & Pallottini, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063408 · Cited by 11 · see citing works

The contributions of bacteria metabolites to the development of hepatic encephalopathy

Gilbert, M. C., Setayesh, T., & Wan, Y. Y. (2022) · Liver Research · doi:10.1016/j.livres.2022.11.005 · Cited by 11 · see citing works

Labelfree mapping and profiling of altered lipid homeostasis in the rat hippocampus after traumatic stress: Role of oxidative homeostasis

Kelley, D. P., Chaichi, A., Duplooy, A., Singh, D. P., Gartia, M. R., & Francis, J. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100476 · Cited by 11 · see citing works

Dopamine Burden Triggers Cholesterol Overload Following Disruption of Synaptogenesis in Minimal Hepatic Encephalopathy

Zhuge, W., Wen, F., Ni, Z., Zheng, Z., Zhu, X., Lin, J., Wang, J., Zhuge, Q., & Ding, S. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.04.056 · Cited by 11 · see citing works

Role of Lipids in Regulation of Neuroglial Interactions

Galkina, O. V., Vetrovoy, O. V., Krasovskaya, I. E., & Eschenko, N. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923030045 · Cited by 10 · see citing works

Unde venisti PGRMC? Grand-Scale Biology from Early Eukaryotes and Eumetazoan Animal Origins

Cahill, M. A. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2711317 · Cited by 9 · see citing works

Mathematical Models for Cholesterol Metabolism and Transport

Zhang, F., Macshane, B., Searcy, R., & Huang, Z. J. (2022) · Processes · doi:10.3390/pr10010155 · Cited by 9 · see citing works

Association of lipid rafts cholesterol with clinical profile in fragile X syndrome

Toupin, A., Benachenhou, S., Abolghasemi, A., Laroui, A., Galarneau, L., Fülöp, T., Corbin, F., & Çaku, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-07064-z · Cited by 9 · see citing works

Impact of Sex and Age on the Mevalonate Pathway in the Brain: A Focus on Effects Induced by Maternal Exposure to Exogenous Compounds

Tonini, C., Segatto, M., & Pallottini, V. (2020) · Metabolites · doi:10.3390/metabo10080304 · Cited by 9 · see citing works

Mechanisms of Sigma‐2/TMEM97 Involvement in Cholesterol Metabolism

Parente, M., Tonini, C., Caputo, S., Fiocchetti, M., & Pallottini, V. (2024) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30645 · Cited by 7 · see citing works

Enzyme-assisted ReMALDI-MS assay for quantification of cholesterol in food

Li, B., Gao, W., Ling, L., & Yu, S. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132444 · Cited by 7 · see citing works

Regulation of cholesterol metabolism: New players for an old physiological process

Parente, M., Tonini, C., Segatto, M., & Pallottini, V. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30477 · Cited by 7 · see citing works

Association of atherogenic index of plasma with early-onset post-stroke depression: a prospective study

Deng, M., Song, K., He, G., Zhao, W., Xu, W., Feng, T., Chen, S., Tong, Y., Fei, Y., Wang, Z., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1563289 · Cited by 5 · see citing works

Melatonin alleviates brain injury in copper-laden rats: Underlying benefits for Wilson’s disease

Zhang, X., Zhou, L., Peng, Y., He, S., Mao, Z., Cai, J., Geng, A., Yang, H., & Huang, P. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116490 · Cited by 5 · see citing works

The Role of Lipids in Implementing Specific Functions in the Central Nervous System

Galkina, O. V., Vetrovoy, O. V., & Eschenko, N. (2021) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162021050253 · Cited by 5 · see citing works

Genetic Association of Lipids and Lipid-Lowering Drug Target Genes With Attention Deficit Hyperactivity Disorder

Guo, D., Sheng, W., Cai, Y., Shu, J., & Cai, C. (2024) · Journal of Attention Disorders · doi:10.1177/10870547231222219 · Cited by 3 · see citing works

Review of methods for the determination of cellular cholesterol content: principles, advantages, limitations, applications, and perspectives

Zhou, Z.-H., Zong, J., & Xu, N. (2025) · Analytical Sciences · doi:10.1007/s44211-025-00842-5 · Cited by 3 · see citing works

Statins in Alzheimer’s disease (AD)

Vitiello, A., Troiano, V., & Porta, R. L. (2022) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-022-03315-0 · Cited by 3 · see citing works

Graduate Student Literature Review: Screening, degradation mechanisms, and applications in dairy products of cholesterol-lowering lactic acid bacteria—A review

Tian, Z., Luo, J., Yuan, W., Tan, L., Xu, C., Zhou, H., Li, M., Wu, Z. F., Zhao, W., Pan, D., et al. (2025) · Journal of Dairy Science · doi:10.3168/jds.2025-27005 · Cited by 2 · see citing works

Cholesterol and nicotinic acetylcholine receptor: An intimate nanometer-scale spatial relationship spanning the billion year time-scale

Barrantes, F. J. (2016) · Biomedical Spectroscopy and Imaging · doi:10.3233/bsi-160158 · Cited by 2 · see citing works

Neurodevelopmental clustering of gene expression identifies lipid metabolism genes associated with neuroprotection and neurodegenerationPreprint

Kohane, A. A., & Wood, T. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.02.458277 · Cited by 2 · see citing works

Macronutrients and micronutrients

Neu, J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99913-7.00002-2 · Cited by 1 · see citing works

Associations of lipids in adolescence and adulthood with self‐ and other‐directed compassion in adulthood

Pihlaja, S., Jääskeläinen, E., Heikkilä, L., & Hintsanen, M. (2024) · Scandinavian Journal of Psychology · doi:10.1111/sjop.13052 · Cited by 1 · see citing works

Neuroimaging biomarkers in school‐aged children with autism: MRI ‐measured lipid content in the limbic system

Deng, Y., Zhou, X., Yin, B., Zou, F., Zhong, S., Luo, X., Shen, L., Yang, F., & Guo, R. (2025) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.70033 · Cited by 1 · see citing works

Mevalonate kinase deficiency: therapeutic targets, treatments, and outcomes

Marcuzzi, A., Piscianz, E., Brumatti, L. V., & Tommasini, A. (2017) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2017.1328308 · Cited by 1 · see citing works

Exploring effects of Simvastatin on coagulation mediators to alleviate the advancement of high cholesterol diet triggered neurodegeneration

Khan, S. I., Hasan, N., Khan, S., Akhtar, M., Akhtar, M., & Najmi, A. K. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23342 · Cited by 1 · see citing works

Evaluation of Hippocampal Allostatic Load-Associated Factors in Animal Models of Post-Traumatic Stress Disorder: Relevance to Human PTSD

Kelley, D. P. (2022) · doi:10.31390/gradschool_dissertations.5761 · Cited by 1 · see citing works

Requirement of cholesterol for calcium-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bendingPreprint

Park, Y., Moussa, H. Y. A., Shin, K. C., Ponraj, J., Mansour, S. A., Ryu, J., & Kim, S. J. (2022) · Research Square · doi:10.21203/rs.3.rs-1313659/v2 · Cited by 1 · see citing works

Deep thoughts on lipids and cognition

Fathallah, M., & Krasuski, R. A. (2017) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000417

Risks of Statins for Lower-Risk Individuals

Regenold, W. T. (2018) · JAMA · doi:10.1001/jama.2017.19170

[Evaluation of psychophysical stress and prevalence of tiredness symptoms in private secondary school students].

Polus-Szeniawska, E. (1993) · PubMed

Requirement of cholesterol for calcium-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bendingPreprint

Moussa, H. Y. A., Shin, K. C., Ponraj, J., Kim, S. J., Ryu, J., Mansour, S. A., & Park, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.03.478933

Requirement of cholesterol for calcium-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bendingPreprint

Park, Y., Moussa, H. Y. A., Shin, K. C., Tong, Y., Mansour, S. A., Kim, S. J. S. J., & Ryu, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1313659/v1

ProRafts: A machine-learning predictor for raftophilicity , the protein affinity for biomembrane raftsPreprint

Yurtsever, D., Keşmir, C., & Sperotto, M. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.20.533471

Hypercholesterolemic diet and status epilepticus

Nogueira, R. D. A., Costa, E. V. L., da Silva, J. E. S., & Pessoa, D. T. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89834-8.00025-8

Contrasting Evidences Between High Cholesterol Levels and The Risk of Cardiovascular Disease: A Review

Saleh, A., & Esievo, K. A. N. (2024) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v14i2.6399

The role of lipid in the regulation of neuroglial interactions

Galkina, O. V., Vetrovoy, O. V., Krasovskaya, I. E., & Eschenko, N. (2023) · Biochemistry (Moscow) · doi:10.31857/s0320972523030041

Lipid Profiles and Liver Enzymes in Autistic Patients in Iraq, a Case-Control Study

Saad, R., & Dawood, Y. J. (2024) · European Multidisciplinary Journal of Modern Science · doi:10.51699/emjms.v26i4.45

Overexpression of cholesterol 24-hydroxylase CYP46A1 attenuates retinal dysfunction and ganglion cell loss via regulating the Nrf2 pathway in optic nerve crush injury

Long, Z., Zhang, J., Feng, J., & He, T. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110649

Brain-specific ORP6 deficiency in mice disrupts systemic lipid metabolism and impairs hippocampal-dependent learning and memory

Kasongo, A. A., Bhunu, B., Boucher, D. M., Vijithakumar, V., Aly, S. H., Emerton, C., Rousseaux, M. W. C., Lagace, D. C., & Ouimet, M. (2026) · Neuroscience Letters · doi:10.1016/j.neulet.2026.138682

Cholesterol Homeostasis Imbalance and Brain Functioning: Neurological Disorders and Behavioral Consequences

Lecis, C., & Segatto, M. (2014) · Journal of Neurology and Neurological Disorders · doi:10.15744/2454-4981.1.101 · Cited by 9 · see citing works

Cholesterol in brain disease: Sometimes determinant and frequently implicated

Martín, M. G., Pfrieger, F., & Dotti, C. G. (2014) · The EMBO Reports · doi:10.15252/embr.201439225 · Cited by 304 · see citing works

Impaired cholesterol metabolism, neurons, and neuropsychiatric disorders

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