Plasma oxysterols in drug-free patients with schizophrenia
Abstract
Evidence from clinical, genetic, and medical studies has shown the neuronal developmental disorder aspect of schizophrenia (SZ). Whereas oxysterols are vital factors in neurodevelopment, it is still unknown whether they are involved in the pathophysiology of SZ. The current study aims to explore the profile of oxysterols in plasma, ratio to total cholesterol (Tchol) and the association with clinical factors in patients with SZ. Forty men diagnosed with SZ and forty healthy controls matched for age and sex were included in the study. The ratios of cholestane-3β,5α,6β-triol, 27-hydroxycholesterol (27-OHC) and Cholestanol to Tchol increased in the schizophrenic group compared to controls. However, levels of 24S-hydroxycholesterol (24-OHC) were not significantly different between patients and controls. For the SZ patients, the plasma 24-OHC levels were positively correlated with the positive and negative syndrome total scores (PANSS) but negatively correlated with the Montreal Cognitive Assessment scores (MOCA). Moreover, the ratio Cholestanol to Tchol was negatively correlated with MOCA scores and positively correlated with PANSS general. The binary logistic regression analysis revealed that the ratio Cholestane-3β,5α,6β-triol/TChol could be considered as an independent risk factor for SZ. On the other hand, the receiver's operating characteristics analysis corresponding to potential biomarkers on SZ showed Areas Under the Curve (AUCs) of 82.1%; 69.7% and 77.6% for the ratio of Cholestane-3β,5α,6β-triol/TChol, 27-OHC/TChol and Cholestanol/TChol respectively. The relevance of Cholestane-3β,5α,6β-triol, 27-OHC and Cholestanol assays as biomarkers of this disease deserves further investigation.
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Plasma calcifediol levels and the ratio of cholestanol to tchol were negatively correlated with MOCA scores in SCZ.
“Plasma calcifediol levels and the ratio of cholestanol to tchol were found to be negatively correlated with Montreal Cognitive Assessment (MOCA) scores [55].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [55]
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Selva-O’Callaghan, A., Bardes, I., Jacas, C., et al. (2010) · Clinical Nuclear Medicine · doi:10.1097/rlu.0b013e3181feed83 · Cited by 8 · see citing works
Ertuğrul, G., Yankol, Y., Mecit, N., Kırımlıoğlu, H., Kanmaz, T., ACARLI, K. S., & Kalayoğlu, M. (2019) · Experimental and Clinical Transplantation · doi:10.6002/ect.2018.0131 · Cited by 6 · see citing works
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Cited by
Sorted by citations
Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers
Zorkina, Y., Ushakova, V., Ochneva, A., Tsurina, A., Abramova, O., Savenkova, V., Goncharova, A., Alekseenko, I., Morozova, I., Riabinina, D., et al. (2024) · Metabolites · doi:10.3390/metabo14020080 · Cited by 36 · see citing works
- Authors
- Guidara, W., Messedi, M., Naifar, M., Maalej, M., Khrouf, W., Grayaa, S., Maalej, M., Bonnefont-Rousselot, D., Lamari, F., & Ayadi, F.
- Affiliations
- University of Sfax (TN)
- Hopital Universitaire Hedi Chaker (TN)
- Sorbonne Université (FR)
- Corresponding author
- Guidara, Wassim
- ORCID
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 221
- Pages
- 106123
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W4229456980
- Cited by
- 11
- References
- 94
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 6
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Higher Education and Scientific Research
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- schizophrenia, 24S-hydroxycholesterol, 27-hydroxycholesterol, cholestane-3β,5α,6β-triol, cholestanol, cholesterol, biomarkers, brain development, PANSS, cognitive function, risk factors
- MeSH terms
- Oxysterols, Cholestanols, Humans, Male, Schizophrenia, Biomarkers, Area Under Curve
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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