Cited by 153biodegradable polymer synthesis and propertiesPolymer crystallization and propertiesBone Tissue Engineering Materials

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The effect of crystallinity on the deformation mechanism and bulk mechanical properties of PLLA

Renouf-Glauser, Annette C., Rose, John, Farrar, David F., Cameron, Ruth Elizabeth·2005·Biomaterials

DOI 10.1016/j.biomaterials.2005.03.002

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Abstract

Poly (l-lactide) is a widely studied biomaterial, currently approved for use in a range of medical devices, however, most in vitro studies have so far focussed upon either the bulk properties during degradation and/or deformation, or on the microstructure of the unloaded material during degradation. This study aimed to combine these approaches through the technique of simultaneous small-angle X-ray scattering and tensile testing at various stages of degradation up to 8 months, on material with a range of induced microstructures. Results showed that the amorphous material deformed by crazing in the dry, wet and degraded states, however, the mechanism by which the craze developed changed significantly on hydration. Despite this difference, there was little change in the bulk mechanical properties. Crystalline materials deformed through crystal-mediated deformation, with contributions from both cavitation and fibrillated shear, but surprisingly, differences in the length scales within the spherulitic structure caused by annealing at different temperatures had very little effect on the mechanism of deformation, though differences were seen in the bulk properties. Furthermore, hydration had little effect on the crystalline materials, though degradation over 8 months resulted in loss of mechanical properties for samples produced at higher annealing temperatures. In conclusion, the introduction of crystallinity had a huge effect on both bulk and microscopic properties of PLLA, but the spherulitic structure of the crystalline material affected the bulk properties significantly more than it did the micromechanism of deformation.

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“However, PLLA is notorious for being a brittle polymer [12,13],”
Background
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“The mechanism of the deformation of the amorphous and crystalline PLLA polymers indicates that the amorphous region could be deformed by crazing, and the crystalline region could show cavitation and fibrillated shear [12].”
Background
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“On the other hand, in crystalline PLLA, deformation under impact loading takes place through the deformation of the crystallites with the contribution of cavitation and fibrillation mechanisms [51].”
Background

Authors: Renouf-Glauser, A. C., Rose, J., Farrar, D. F., & Cameron, R. E.
Affiliations: University of Cambridge (GB)
Smith & Nephew (United Kingdom) (GB)
Corresponding author: Cameron, Ruth Elizabeth
ORCID: Farrar, David F.
Cameron, Ruth Elizabeth
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2005-10
Volume: 26
Issue: 29
Pages: 5771-5782
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2005.03.002
OpenAlex: W2075491047
Cited by: 153
References: 26
Citations by year: 2026: 5 · 2025: 10 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 12 · 2016: 12 · 2015: 8 · 2014: 8 · 2013: 10 · 2012: 8
FWCI: 2.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: Smith and Nephew
Engineering and Physical Sciences Research Council
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Physical Sciences › Materials Science › Polymers and Plastics › Polymer crystallization and properties
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords: poly(L-lactic acid), crystallinity, deformation mechanisms, bulk mechanical properties, polymer degradation, crazing, spherulitic structure, annealing temperature, hydration, cavitation
MeSH terms: Biocompatible Materials, Fourier Analysis, Materials Testing, Polyesters, Polymers, Scattering, Radiation, Stress, Mechanical, Temperature, Tensile Strength, Time Factors, Water, X-Ray Diffraction, X-Rays, Crystallography, X-Ray, Lactic Acid, Absorbable Implants

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The effect of crystallinity on the deformation mechanism and bulk mechanical properties of PLLA

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