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Cited by 153biodegradable polymer synthesis and propertiesPolymer crystallization and propertiesBone Tissue Engineering Materials

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

The effect of crystallinity on the deformation mechanism and bulk mechanical properties of PLLA

Renouf-Glauser, Annette C., Rose, John, Farrar, David F., Cameron, Ruth Elizabeth·2005·Biomaterials
DOI 10.1016/j.biomaterials.2005.03.002
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Abstract

Poly (l-lactide) is a widely studied biomaterial, currently approved for use in a range of medical devices, however, most in vitro studies have so far focussed upon either the bulk properties during degradation and/or deformation, or on the microstructure of the unloaded material during degradation. This study aimed to combine these approaches through the technique of simultaneous small-angle X-ray scattering and tensile testing at various stages of degradation up to 8 months, on material with a range of induced microstructures. Results showed that the amorphous material deformed by crazing in the dry, wet and degraded states, however, the mechanism by which the craze developed changed significantly on hydration. Despite this difference, there was little change in the bulk mechanical properties. Crystalline materials deformed through crystal-mediated deformation, with contributions from both cavitation and fibrillated shear, but surprisingly, differences in the length scales within the spherulitic structure caused by annealing at different temperatures had very little effect on the mechanism of deformation, though differences were seen in the bulk properties. Furthermore, hydration had little effect on the crystalline materials, though degradation over 8 months resulted in loss of mechanical properties for samples produced at higher annealing temperatures. In conclusion, the introduction of crystallinity had a huge effect on both bulk and microscopic properties of PLLA, but the spherulitic structure of the crystalline material affected the bulk properties significantly more than it did the micromechanism of deformation.

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Crossref · 10.1016/j.biomaterials.2005.03.002

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Research works printed but not linked: 2

  1. Kohn J, Langer R. Biresorbable and bioerodable materials. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE, editors. Biomaterials science, an introduction to materials science. San Diego: Academic Press; 1996.
  2. Tsuji, 1997, Blends of crystalline and amorphous poly(lactide) III, Hydrolysis of solution-cast blend films. J Appl Polym Sci, 63, 855

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Metadata

Authors
Renouf-Glauser, A. C., Rose, J., Farrar, D. F., & Cameron, R. E.
Affiliations
  • University of Cambridge (GB)
  • Smith & Nephew (United Kingdom) (GB)
Corresponding author
Cameron, Ruth Elizabeth
ORCID
Venue
Biomaterials
Publisher
Elsevier BV
Published
2005-10
Volume
26
Issue
29
Pages
5771-5782
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2005.03.002
OpenAlex
W2075491047
Cited by
153
References
26
Citations by year
2026: 5 · 2025: 10 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 12 · 2016: 12 · 2015: 8 · 2014: 8 · 2013: 10 · 2012: 8
FWCI
2.55
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Smith and Nephew
  • Engineering and Physical Sciences Research Council
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer crystallization and properties
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
poly(L-lactic acid), crystallinity, deformation mechanisms, bulk mechanical properties, polymer degradation, crazing, spherulitic structure, annealing temperature, hydration, cavitation
MeSH terms
Biocompatible Materials, Fourier Analysis, Materials Testing, Polyesters, Polymers, Scattering, Radiation, Stress, Mechanical, Temperature, Tensile Strength, Time Factors, Water, X-Ray Diffraction, X-Rays, Crystallography, X-Ray, Lactic Acid, Absorbable Implants

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