The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Freeze casting of hydroxyapatite scaffolds for bone tissue engineering
Open accessAbstract
Although extensive efforts have been put into the development of porous scaffolds for bone regeneration, with encouraging results, all porous materials have a common limitation: the inherent lack of strength associated with porosity. Hence, the development of porous hydroxyapatite scaffolds has been hindered to non-load bearing applications. We report here how freeze casting can be applied to synthesize porous scaffolds exhibiting unusually high compressive strength, e.g. up to 145 MPa for 47% porosity and 65 MPa for 56% porosity. The materials are characterized by well-defined pore connectivity along with directional and completely open porosity. Various parameters affecting the porosity and compressive strength have been investigated, including initial slurry concentration, freezing rate, and sintering conditions. The implications and potential application as bone substitute are discussed. These results might open the way for hydroxyapatite-based materials designed for load-bearing applications. The biological response of these materials is yet to be tested.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Biomechanics. Mechanical Properties of Living Tissues
Fung, Y. C., & Skalak, R. (1982) · Journal of Applied Mechanics · doi:10.1115/1.3162171 · Cited by 6,025
Biomechanics: Mechanical Properties of Living Tissues
Fung, Y. C., & Skalak, R. (1981) · Journal of Biomechanical Engineering · doi:10.1115/1.3138285 · Cited by 2,769
Osteoblast adhesion on biomaterials
Anselme, K. (2000) · Biomaterials · doi:10.1016/s0142-9612(99)00242-2 · Cited by 2,500
Suchanek, W., & Yoshimura, M. (1998) · Journal of Materials Research · doi:10.1557/jmr.1998.0015 · Cited by 2,028
Freezing as a Path to Build Complex Composites
Deville, S., Saiz, E., Nalla, R. K., & Tomsia, A. P. (2006) · Science · doi:10.1126/science.1120937 · Cited by 1,900
Self-citationPorous chitosan scaffolds for tissue engineering
Madihally, S. V., & Matthew, H. W. T. (1999) · Biomaterials · doi:10.1016/s0142-9612(99)00011-3 · Cited by 1,583
Zhang, R., & Ma, P. X. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19990315)44:4<446::aid-jbm11>3.0.co;2-f · Cited by 890
Pore Size of Porous Hydroxyapatite as the Cell-Substratum Controls BMP-Induced Osteogenesis
Tsuruga, E., Takita, H., Itoh, H., Wakisaka, Y., & Kuboki, Y. (1997) · Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021589 · Cited by 706
In vitro characterization of chitosan–gelatin scaffolds for tissue engineering
Huang, Y., Onyeri, S., Siewe, M., Moshfeghian, A., & Madihally, S. V. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.036 · Cited by 656
Osteoconduction at porous hydroxyapatite with various pore configurations
Chang, B.-S., Lee, >. K. >.-K., Hong, K.-S., Youn, H.-J., Ryu, H.-S., Chung, S.-S., & Park, K.-W. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00030-2 · Cited by 635
Cited by
Biological materials: Structure and mechanical properties
Meyers, M. A., Chen, P.-Y., Lin, A. Y.-M., & Seki, Y. (2008) · Progress in Materials Science · doi:10.1016/j.pmatsci.2007.05.002 · Cited by 2,573
Freeze‐Casting of Porous Ceramics: A Review of Current Achievements and Issues
Deville, S. (2008) · Advanced Engineering Materials · doi:10.1002/adem.200700270 · Cited by 1,260
Self-citationMicrostructurally inhomogeneous composites: Is a homogeneous reinforcement distribution optimal?
Huang, L. J., Geng, L., & Peng, H.-X. (2015) · Progress in Materials Science · doi:10.1016/j.pmatsci.2015.01.002 · Cited by 788
Cell proliferation and migration in silk fibroin 3D scaffolds
Mandal, B. B., & Kundu, S. C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.02.006 · Cited by 583
Bioactive polymeric scaffolds for tissue engineering
Stratton, S., Shelke, N. B., Hoshino, K., Rudraiah, S., & Kumbar, S. G. (2016) · Bioactive Materials · doi:10.1016/j.bioactmat.2016.11.001 · Cited by 469
Metadata
- Authors
- Deville, S., Saiz, E., & Tomsia, A. P.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 27
- Issue
- 32
- Pages
- 5480-5489
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2036978569
- Cited by
- 873
- References
- 50
- FWCI
- 22.18
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Freeze casting of hydroxyapatite scaffolds for bone tissue engineering. https://app.cochat.ai/papers/10.1016/j.biomaterials.2006.06.028
- The paper
- Deville, S., Saiz, E., & Tomsia, A. P. (2006). Freeze casting of hydroxyapatite scaffolds for bone tissue engineering. Biomaterials. https://doi.org/10.1016/j.biomaterials.2006.06.028
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
