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The role of cerium redox state in the SOD mimetic activity of nanoceria
Open accessAbstract
Cerium oxide nanoparticles (nanoceria) have recently been shown to protect cells against oxidative stress in both cell culture and animal models. Nanoceria has been shown to exhibit superoxide dismutase (SOD) activity using a ferricytochrome C assay, and this mimetic activity that has been postulated to be responsible for cellular protection by nanoceria. The nature of nanoceria's antioxidant properties, specifically what physical characteristics make nanoceria effective at scavenging superoxide anion, is poorly understood. In this study electron paramagnetic resonance (EPR) analysis confirms the reactivity of nanoceria as an SOD mimetic. X-ray photoelectron spectroscopy (XPS) and UV-visible analyses of nanoceria treated with hydrogen peroxide demonstrate that a decrease in the Ce 3(+)/4(+) ratio correlates directly with a loss of SOD mimetic activity. These results strongly suggest that the surface oxidation state of nanoceria plays an integral role in the SOD mimetic activity of nanoceria and that ability of nanoceria to scavenge superoxide is directly related to cerium(III) concentrations at the surface of the particle.
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Cited by
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Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Fundamentals and Catalytic Applications of CeO 2 -Based Materials
Montini, T., Melchionna, M., Monai, M., & Fornasiero, P. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00603 · Cited by 2,766
Catalytically Active Nanomaterials: A Promising Candidate for Artificial Enzymes
Lin, Y., Ren, J., & Qu, X. (2014) · Accounts of Chemical Research · doi:10.1021/ar400250z · Cited by 1,252
Cerium Oxide Nanoparticles: Applications and Prospects in Nanomedicine
Das, S., Dowding, J. M., Klump, K. E., McGinnis, J. F., Self, W., & Seal, S. (2013) · Nanomedicine · doi:10.2217/nnm.13.133 · Cited by 561
Self-citationWu, H., Tito, N., & Giraldo, J. P. (2017) · ACS Nano · doi:10.1021/acsnano.7b05723 · Cited by 533
Metadata
- Authors
- Heckert, E. G., Karakoti, A. S., Seal, S., & Self, W. T.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 29
- Issue
- 18
- Pages
- 2705-2709
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2011676749
- Cited by
- 1,014
- References
- 0
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Heckert, E. G., Karakoti, A. S., Seal, S., & Self, W. T. (2008). The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials. https://doi.org/10.1016/j.biomaterials.2008.03.014
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