The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Biohybrid thin films for measuring contractility in engineered cardiovascular muscle
Open accessAbstract
In vitro cardiovascular disease models need to recapitulate tissue-scale function in order to provide in vivo relevance. We have developed a new method for measuring the contractility of engineered cardiovascular smooth and striated muscle in vitro during electrical and pharmacological stimulation. We present a growth theory-based finite elasticity analysis for calculating the contractile stresses of a 2D anisotropic muscle tissue cultured on a flexible synthetic polymer thin film. Cardiac muscle engineered with neonatal rat ventricular myocytes and paced at 0.5 Hz generated stresses of 9.2 ± 3.5 kPa at peak systole, similar to measurements of the contractility of papillary muscle from adult rats. Vascular tissue engineered with human umbilical arterial smooth muscle cells maintained a basal contractile tone of 13.1 ± 2.1 kPa and generated another 5.1 ± 0.8 kPa when stimulated with endothelin-1. These data suggest that this method may be useful in assessing the efficacy and safety of pharmacological agents on cardiovascular tissue.
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Muscular Thin Films for Building Actuators and Powering Devices
Feinberg, A. W., Feigel, A., Shevkoplyas, S. S., Sheehy, S., Whitesides, G. M., & Parker, K. K. (2007) · Science · doi:10.1126/science.1146885 · Cited by 765
Self-citationEschenhagen, T., Fink, C., Remmers, U., Scholz, H., Wattchow, J., Weil, J., Zimmermann, W., Dohmen, H. H., Schäfer, H., Bishopric, N., et al. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.8.9240969 · Cited by 636
Cited by
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Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.005 · Cited by 1,834
Wang, G., McCain, M. L., Yang, L., He, A., Pasqualini, F. S., Agarwal, A., Yuan, H., Jiang, D., Zhang, D., Zangi, L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3545 · Cited by 837
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Fu, F., Shang, L., Chen, Z., Yu, Y., & Zhao, Y. (2018) · Science Robotics · doi:10.1126/scirobotics.aar8580 · Cited by 587
Engineered In Vitro Disease Models
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554
Self-citationNanofiber Assembly by Rotary Jet-Spinning
Badrossamay, M. R., McIlwee, H. A., Goss, J. A., & Parker, K. K. (2010) · Nano Letters · doi:10.1021/nl101355x · Cited by 518
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Metadata
- Authors
- Alford, P. W., Feinberg, A. W., Sheehy, S. P., & Parker, K. K.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 31
- Issue
- 13
- Pages
- 3613-3621
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2147086117
- Cited by
- 168
- References
- 2
- FWCI
- 10.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Alford, P. W., Feinberg, A. W., Sheehy, S. P., & Parker, K. K. (2010). Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials. https://doi.org/10.1016/j.biomaterials.2010.01.079
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