Mussel-inspired transformation of CaCO3 to bone minerals
Abstract
We report a mussel-inspired route to create carbonated bone hydroxyapatite from CaCO(3) vaterite microspheres. When catechol-containing dopamine, a biomimetic small molecule of mussel adhesive proteins, was incorporated during the mineralization of CaCO(3), the oxidative polymerization of dopamine stabilized the formation of spherical vaterite, the most unstable phase among CaCO(3) crystalline structures. Thus-formed vaterite microspheres were readily transformed to carbonated hydroxyapatite crystals when incubated in a simulated body fluid at human body temperature. We found that dopamine not only stabilized the vaterite phase but also influenced the level of conversion to carbonated hydroxyapatites. Considering that carbonated hydroxyapatites are highly bioresorbable, similar to natural bone and dentin, the synthesis of a mussel-inspired hybrid material showing good in vitro bone bioactivity should present a new prospect for future applications in the treatment of bone defects and bone degenerative diseases.
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CaCO3 crystalline microspheres incorporating DA are easily transformed into carbonated HA crystals when incubated in SBF at human body temperature.
“Kim et al. synthesized CaCO3 crystalline microspheres by incorporating DA that was easily transformed into carbonated HA crystals when incubated in SBF at human body temperature [64].”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [64]
Cites
Taking advantage of disorder: amorphous calcium carbonate and its roles in biomineralization
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Metals and the Integrity of a Biological Coating: The Cuticle of Mussel Byssus
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Dopamine Modified Organic–Inorganic Hybrid Coating for Antimicrobial and Osteogenesis
Li, M., Liu, X., Xu, Z., Yeung, K. W. K., & Wu, S. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b09457 · Cited by 154 · see citing works
Kaushik, N., Nhat Nguyen, L., Kim, J. H., Choi, E. H., & Kumar Kaushik, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186544 · Cited by 76 · see citing works
“synthesized CaCO3 crystalline microspheres by incorporating DA that was easily transformed into carbonated HA crystals when incubated in SBF at human body temperature [64].”
BackgroundLiu, Z., Qu, S., Zheng, X., Xiong, X., Fu, R., Tang, K., Zhong, Z., & Weng, J. (2014) · Materials Science and Engineering: C · doi:10.1016/j.msec.2014.07.063 · Cited by 67 · see citing works
- Authors
- Kim, S., & Park, C. B.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Corresponding author
- Park, Chan Beum
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 31
- Issue
- 25
- Pages
- 6628-6634
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2080623509
- Cited by
- 125
- References
- 2
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 10 · 2021: 7 · 2020: 12 · 2019: 9 · 2018: 14 · 2017: 5 · 2016: 9 · 2015: 10 · 2014: 14 · 2013: 4 · 2012: 5
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Calcium Carbonate Crystallization and Inhibition
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Applications in Construction Materials
- Keywords
- mussel-inspired synthesis, vaterite, carbonated hydroxyapatite, dopamine, catechol, biomimetic mineralization, calcium carbonate, simulated body fluid, bioresorbable materials, bone defect repair, oxidative polymerization
- MeSH terms
- Animals, Bone and Bones, Calcium Carbonate, Crystallization, Dopamine, Minerals, Durapatite, Biomimetics, Bivalvia
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