Cited by 155Bone Tissue Engineering MaterialsSurface Treatment and CoatingsNanoparticles: synthesis and applications

Dopamine Modified Organic–Inorganic Hybrid Coating for Antimicrobial and Osteogenesis

Li, Man, Liu, Xiangmei, Xu, Ziqiang, Yeung, K.W.K., Wu, Shuilin·2016·ACS Applied Materials & Interfaces

Abstract

A hybrid coating composed of hydroxyapatite (HA), Ag nanoparticles (NPs), and chitosan (CS) was successfully prepared on a Ti substrate by a layer-by-layer assembly process. A polydopamine-assisted (PDA-assisted) coating showed a good bond with HA. Ag NPs were uniformly distributed into the hybrid coating through a solution method and ultraviolet light reduction. A CS nanofilm was deposited via spin-coating to control the release of Ag + from the hybrid coating. The results disclosed that the 3-layer CS coating could efficiently control the release of Ag + from the hybrid coating via the Fickian diffusion mechanism and that the PDA/HA/Ag/CS-1 coating exhibited antibacterial ratios of 63.0% and 51.8% against E. coli and S. aureus, respectively. Furthermore, the normal structure of E. coli was obviously destroyed by two types of Ag doped coatings. The cell viability assay showed that CS effectively reduced the cytotoxicity of the hybrid coating after a 7 day incubation. The hybrid coating presented high ALP activities at days 3 and 14. The results reveal that hybrid coatings can endow Ti implants with good antibacterial capability as well as cell viability and osteogenic activity.

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Crossref · 10.1021/acsami.6b09457

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Authors
Li, M., Liu, X., Xu, Z., Yeung, K. W. K., & Wu, S.
Affiliations
  • Hubei University (CN)
  • University of Hong Kong - Shenzhen Hospital (CN)
Corresponding author
Wu, Shuilin
Venue
ACS Applied Materials & Interfaces
Published
2016-11-30
Volume
8
Issue
49
Pages
33972-33981
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W2557402634
Cited by
154
References
60
Citations by year
2026: 1 · 2025: 2 · 2024: 14 · 2023: 13 · 2022: 14 · 2021: 21 · 2020: 19 · 2019: 24 · 2018: 24 · 2017: 21 · 2016: 1
FWCI
11.23
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Funders
  • Ministry of Science and Technology of the People's Republic of China (2014CB660809)
  • National Natural Science Foundation of China (21603067, 51422102, 51671081, 81271715)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Keywords
polydopamine, hydroxyapatite, silver nanoparticles, chitosan, organic-inorganic hybrid coatings, titanium implants, antibacterial coatings, osteogenic activity, silver ion release, layer-by-layer assembly, Escherichia coli, Staphylococcus aureus, cytotoxicity, alkaline phosphatase activity
MeSH terms
Anti-Bacterial Agents, Dopamine, Escherichia coli, Osteogenesis, Silver, Staphylococcus aureus, Titanium, Durapatite, Coated Materials, Biocompatible

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