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Cited by 827Bone Tissue Engineering MaterialsDental Implant Techniques and OutcomesSurface Treatment and Coatings

The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation

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Gittens, Rolando A., McLachlan, Taylor, Olivares-Navarrete, Rene, Cai, Ye, Berner, Simon, Tannenbaum, Rina, Schwartz, Zvi, Sandhage, Kenneth H. +1 more·2011·Biomaterials
DOI 10.1016/j.biomaterials.2011.01.029PMC PMC3350795
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Abstract

Titanium (Ti) osseointegration is critical for the success of dental and orthopedic implants. Previous studies have shown that surface roughness at the micro- and submicro-scales promotes osseointegration by enhancing osteoblast differentiation and local factor production. Only relatively recently have the effects of nanoscale roughness on cell response been considered. The aim of the present study was to develop a simple and scalable surface modification treatment that introduces nanoscale features to the surfaces of Ti substrates without greatly affecting other surface features, and to determine the effects of such superimposed nano-features on the differentiation and local factor production of osteoblasts. A simple oxidation treatment was developed for generating controlled nanoscale topographies on Ti surfaces, while retaining the starting micro-/submicro-scale roughness. Such nano-modified surfaces also possessed similar elemental compositions, and exhibited similar contact angles, as the original surfaces, but possessed a different surface crystal structure. MG63 cells were seeded on machined (PT), nano-modified PT (NMPT), sandblasted/acid-etched (SLA), and nano-modified SLA (NMSLA) Ti disks. The results suggested that the introduction of such nanoscale structures in combination with micro-/submicro-scale roughness improves osteoblast differentiation and local factor production, which, in turn, indicates the potential for improved implant osseointegration in vivo.

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Authors
Gittens, R. A., McLachlan, T., Olivares-Navarrete, R., Cai, Y., Berner, S., Tannenbaum, R., Schwartz, Z., Sandhage, K. H., & Boyan, B. D.
Affiliations
  • Georgia Institute of Technology (US)
  • Straumann (Switzerland) (CH)
Corresponding author
Boyan, Barbara D.
ORCID
Venue
Biomaterials
Publisher
Elsevier BV
Published
2011-05
Volume
32
Issue
13
Pages
3395-3403
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2011.01.029
PMC
PMC3350795
OpenAlex
W2116790557
Cited by
827
References
0
Citations by year
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FWCI
25.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Public Health Service
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR052102, AR052102)
  • Air Force Office of Scientific Research
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
  • Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
Keywords
titanium implants, osseointegration, surface roughness, nanoscale surface features, osteogenic differentiation, cell proliferation, sandblasted acid-etched titanium, machined titanium, surface topography, MG-63 cells, dental implants
MeSH terms
Cell Differentiation, Humans, Osteoblasts, Surface Properties, Titanium, X-Ray Diffraction, Microscopy, Atomic Force, Cell Line, Tumor, Microscopy, Electron, Transmission, Cell Proliferation

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