Carboxyl-ebselen-based layer-by-layer films as potential antithrombotic and antimicrobial coatings
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A carboxyl-ebselen-based layer-by-layer (LbL) film was fabricated by alternatively assembling carboxyl-ebselen immobilized polyethylenimine (e-PEI) and alginate (Alg) onto substrates followed by salt annealing and cross-linking. The annealed films exhibiting significantly improved stability are capable of generating nitric oxide (NO) from endogeneous S-nitrosothiols (RSNOs) in the presence of a reducing agent. The NO generation behaviors of different organoselenium species in solution phase are compared and the annealing mechanism to create stable LbL films is studied in detail. An LbL film coated polyurethane catheter is capable of generating physiological levels of NO from RSNOs even after blood soaking for 24 h, indicating potential antithrombotic applications of the coating. Further, the LbL film is also demonstrated to be capable of reducing living bacterial surface attachment and killing a broad spectrum of bacteria, likely through generation of superoxide (O(2)(·-)) from oxygen. This type of film is expected to have potential application as an antithrombotic and antimicrobial coating for different biomedical device surfaces.
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Enzymes such as CuZn-SOD or GPx can convert RSNO to NO in the presence of a reducing agent like GSH.
“Further, certain enzymes such as copper-containing superoxide dismutase (CuZn-SOD)140,176 or the selenium-containing enzyme glutathione peroxidase (GPx)140,171,173 can also convert RSNO to NO in the presence of a reducing agent, such as glutathione (GSH)”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [173]
Metal ions such as copper or ferrous ions, or organoselenium compounds, can catalyze RSNO decomposition.
“Metal ions (such as copper or ferrous ions)169,170 or organoselenium compounds can catalyze RSNO decomposition.114,171–173”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [173]
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Cites
Frost, M. C., Reynolds, M. M., & Meyerhoff, M. E. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.006 · Cited by 343 · see citing works
Self-citationEstimation of nitric oxide production and reactionrates in tissue by use of a mathematical model
Vaughn, M. W., Kuo, L., & Liao, J. C. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.6.h2163 · Cited by 338 · see citing works
Catalytic generation of nitric oxide from S-nitrosothiols using immobilized organoselenium species
Cha, W., & Meyerhoff, M. E. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.08.019 · Cited by 140 · see citing works
Self-citationYang, J., Welby, J. L., & Meyerhoff, M. E. (2008) · Langmuir · doi:10.1021/la801466e · Cited by 55 · see citing works
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Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Self-citationColletta, A., Wu, J., Wo, Y., Kappler, M., Chen, H., Xi, C., & Meyerhoff, M. E. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00032 · Cited by 89 · see citing works
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- Authors
- Cai, W., Wu, J., Xi, C., Ashe, A. J., & Meyerhoff, M. E.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Meyerhoff, Mark E.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 32
- Issue
- 31
- Pages
- 7774-7784
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC3159861
- OpenAlex
- W2030971921
- Cited by
- 72
- References
- 4
- Citations by year
- 2024: 5 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 2 · 2016: 6 · 2015: 11 · 2014: 13 · 2013: 3 · 2012: 3
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (EB-004527)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Organoselenium and organotellurium chemistry
- Keywords
- layer-by-layer films, polyethyleneimine, alginate, crosslinking, nitric oxide production, S-nitrosothiols, antithrombotic coatings, antimicrobial coatings, polyurethane catheters, bacterial adhesion, superoxide, organoselenium compounds
- MeSH terms
- Animals, Anti-Infective Agents, Antithrombins, Azoles, Catalysis, Cross-Linking Reagents, Escherichia coli, Microbial Sensitivity Tests, Microscopy, Electron, Scanning, Microscopy, Fluorescence, Nitric Oxide, Polyethyleneimine, Selenium, Sheep, Spectrophotometry, Ultraviolet, Superoxides, Free Radical Scavengers, Organoselenium Compounds, Coated Materials, Biocompatible, S-Nitrosothiols, Microbial Viability, Isoindoles
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