Estimation of nitric oxide production and reactionrates in tissue by use of a mathematical model
Abstract
Nitric oxide (NO) produced by the vascular endothelium is an important biologic messenger that regulates vessel tone and permeability and inhibits platelet adhesion and aggregation. NO exerts its control of vessel tone by interacting with guanylyl cyclase in the vascular smooth muscle to initiate a series of reactions that lead to vessel dilation. Previous efforts to investigate this interaction by mathematical modeling of NO diffusion and reaction have been hampered by the lack of information on the production and degradation rate of NO. We use a mathematical model and previously published experimental data to estimate the rate of NO production, 6.8 × 10 −14 μmol ⋅ μm −2 ⋅ s −1 ; the NO diffusion coefficient, 3,300 μm 2 s −1 ; and the NO consumption rate coefficient in the vascular smooth muscle, 0.01 s −1 (1st-order rate expression) or 0.05 μM −1 ⋅ s −1 (2nd-order rate expression). The modeling approach is discussed in detail. It provides a general framework for modeling the NO produced from the endothelium and for estimating relevant physical parameters.
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The human body synthesizes bio-regulatory NO from L-arginine via three NOS isoforms: eNOS, nNOS, and iNOS.
“The human body synthesizes a large quantity of bio-regulatory NO from the substrate L-arginine via three distinct isoforms of nitric oxide synthase (NOS), including endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS).118–120”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [118]
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- Authors
- Vaughn, M. W., Kuo, L., & Liao, J. C.
- Affiliations
- Texas A&M Health Science Center (US)
- University of California, Los Angeles (US)
- Venue
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Published
- 1998-06-01
- Volume
- 274
- Issue
- 6
- Pages
- H2163-H2176
- ISSN
- 0363-6135 (ISSN-L)
- 1522-1539
- OpenAlex
- W1827044363
- Cited by
- 338
- References
- 27
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 17 · 2020: 16 · 2019: 17 · 2018: 11 · 2017: 16 · 2016: 14 · 2015: 16 · 2014: 12 · 2013: 13 · 2012: 12
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- nitric oxide, vascular endothelium, vascular smooth muscle, guanylate cyclase, parameter estimation, mathematical modeling, vasodilation
- MeSH terms
- Endothelium, Vascular, Models, Biological, Muscle, Smooth, Vascular, Nitric Oxide
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