The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Polymer encapsulated upconversion nanoparticle/iron oxide nanocomposites for multimodal imaging and magnetic targeted drug delivery
Abstract
Multimodal imaging and imaging-guided therapies have become a new trend in the current development of cancer theranostics. In this work, we encapsulate hydrophobic upconversion nanoparticles (UCNPs) together with iron oxide nanoparticles (IONPs) by using an amphiphilic block copolymer, poly (styrene-block-allyl alcohol) (PS(16)-b-PAA(10)), via a microemulsion method, obtaining an UC-IO@Polymer multi-functional nanocomposite system. Fluorescent dye and anti-cancer drug molecules can be further loaded inside the UC-IO@Polymer nanocomposite for additional functionalities. Utilizing the Squaraine (SQ) dye loaded nanocomposite (UC-IO@Polymer-SQ), triple-modal upconversion luminescence (UCL)/down-conversion fluorescence (FL)/magnetic resonance (MR) imaging is demonstrated in vitro and in vivo, and also applied for in vivo cancer cell tracking in mice. On the other hand, a chemotherapy drug, doxorubicin, is also loaded into the nanocomposite, forming an UC-IO@Polymer-DOX complex, which enables novel imaging-guided and magnetic targeted drug delivery. Our work provides a method to fabricate a nanocomposite system with highly integrated functionalities for multimodal biomedical imaging and cancer therapy.
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“Upon surface-modification, the resulting superparamagnetic iron oxide nanoparticles (SPION) can be employed for magnetic resonance imaging (MRI) [4–8], magnetic particle imaging (MPI) [9–12], targeted delivery of drugs, proteins, antibodies, and nucleic acids [6, 7, 13, 14], hyperthermia [15–17], biosensing [18], tissue repair [19], and separation of biomolecules [20].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [6]
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Biopolymeric-inorganic composites for drug delivery
Goel, R., & Bhardwaj, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-323-95751-9.00007-6
Metadata
- Authors
- Xu, H., Cheng, L., Wang, C., Ma, X., Li, Y., & Liu, Z.
- Affiliations
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Corresponding author
- Li, Yonggang
- Liu, Zhuang
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 32
- Issue
- 35
- Pages
- 9364-9373
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1964991943
- Cited by
- 301
- References
- 33
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 14 · 2022: 17 · 2021: 20 · 2020: 13 · 2019: 18 · 2018: 24 · 2017: 30 · 2016: 21 · 2015: 27 · 2014: 28 · 2013: 34 · 2012: 32
- FWCI
- 14.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Soochow University
- Specialized Research Fund for the Doctoral Program of Higher Education of China
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- upconversion nanoparticles, iron oxide nanoparticles, polymer nanocomposites, amphiphilic block copolymers, microemulsion polymerization, multimodal imaging, upconversion luminescence, magnetic resonance imaging, squaraine dyes, doxorubicin, cancer theranostics, tumor cell tracking, image-guided therapy
- MeSH terms
- Animals, Doxorubicin, Ferric Compounds, Fluorescence, Humans, Injections, Intravenous, Magnetic Resonance Spectroscopy, Polymers, Drug Delivery Systems, Imaging, Three-Dimensional, Cell Line, Tumor, Mice, Nanoparticles, Nanocomposites
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