The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments
Open accessAbstract
Angiogenesis is the formation of new blood vessels from existing blood vessels and is critical for many physiological and pathophysiological processes. In this study we have shown the unique property of cerium oxide nanoparticle (CNPs) to induce angiogenesis, observed using both in vitro and in vivo model systems. In particular, CNPs trigger angiogenesis by modulating the intracellular oxygen environment and stabilizing hypoxia inducing factor 1α endogenously. Furthermore, correlations between angiogenesis induction and CNPs physicochemical properties including: surface Ce3+/Ce4+ ratio, surface charge, size, and shape were also explored. High surface area and increased Ce3+/Ce4+ ratio make CNPs more catalytically active towards regulating intracellular oxygen, which in turn led to more robust induction of angiogenesis. Atomistic simulation was also used, in partnership with in vitro and in vivo experimentation, to reveal that the surface reactivity of CNPs and facile oxygen transport promotes pro-angiogenesis.
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Cites
1 retracted
Mitochondrial dysfunction and HIF1α stabilization in inflammation
Garedew, A., & Moncada, S. (2008) · Journal of Cell Science · doi:10.1242/jcs.034660 · Cited by 28
RetractedOxygen Vacancies and Catalysis on Ceria Surfaces
Campbell, C. T., & Peden, C. H. F. (2005) · Science · doi:10.1126/science.1113955 · Cited by 1,400
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
Facciabene, A., Peng, X., Hagemann, I. S., Balint, K., Barchetti, A., Wang, L.-P., Gimotty, P. A., Gilks, C. B., Lal, P., Zhang, L., et al. (2011) · Nature · doi:10.1038/nature10169 · Cited by 1,376
Pharmacological potential of cerium oxide nanoparticles
Celardo, I., Pedersen, J. Z., Traversa, E., & Ghibelli, L. (2011) · Nanoscale · doi:10.1039/c0nr00875c · Cited by 1,151
Size dependency variation in lattice parameter and valency states in nanocrystalline cerium oxide
Deshpande, S., Patil, S., Kuchibhatla, S. V., & Seal, S. (2005) · Applied Physics Letters · doi:10.1063/1.2061873 · Cited by 1,135
Self-citationTargeting the tumour vasculature: insights from physiological angiogenesis
Chung, A. S., Lee, J., & Ferrara, N. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2868 · Cited by 752
Anti‐inflammatory Properties of Cerium Oxide Nanoparticles
Hirst, S. M., Karakoti, A. S., Tyler, R. D., Sriranganathan, N., Seal, S., & Reilly, C. M. (2009) · Small · doi:10.1002/smll.200901048 · Cited by 727
Self-citationYoshida, S., Ono, M., Shono, T., Izumi, H., Ishibashi, T., Suzuki, H., & Kuwano, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.4015 · Cited by 696
Converting Ceria Polyhedral Nanoparticles into Single-Crystal Nanospheres
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Self-citationRedox signaling in angiogenesis: Role of NADPH oxidase
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Cited by
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Cerium Oxide Nanoparticles: Applications and Prospects in Nanomedicine
Das, S., Dowding, J. M., Klump, K. E., McGinnis, J. F., Self, W., & Seal, S. (2013) · Nanomedicine · doi:10.2217/nnm.13.133 · Cited by 561
Self-citationCerium Oxide Nanoparticles: A Brief Review of Their Synthesis Methods and Biomedical Applications
Dhall, A., & Self, W. (2018) · Antioxidants · doi:10.3390/antiox7080097 · Cited by 482
Self-citationNguyen, D. D., & Lai, J.-Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.134970 · Cited by 178
Ren, S., Zhou, Y., Zheng, K., Xu, X., Yang, J., Wang, X., Miao, L., Wei, H., & Xu, Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.05.037 · Cited by 147
Metadata
- Authors
- Das, S., Singh, S., Dowding, J. M., Oommen, S., Kumar, A., Sayle, T. X. T., Saraf, S., Patra, C. R., Vlahakis, N. E., Sayle, D. C., Self, W. T., & Seal, S.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 33
- Issue
- 31
- Pages
- 7746-7755
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2079526353
- Cited by
- 309
- References
- 28
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Das, S., Singh, S., Dowding, J. M., Oommen, S., Kumar, A., Sayle, T. X. T., Saraf, S., Patra, C. R., Vlahakis, N. E., Sayle, D. C., Self, W. T., & Seal, S. (2012). The induction of angiogenesis by cerium oxide nanoparticles through the modulation of oxygen in intracellular environments. Biomaterials. https://doi.org/10.1016/j.biomaterials.2012.07.019
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