Cited by 54Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsRNA Interference and Gene Delivery

Tumor cells-specific targeting delivery achieved by A54 peptide functionalized polymeric micelles

Du, Yong-Zhong, Cai, Li-Li, Liu, Ping, You, Jian, Yuan, Hong, Hu, Fu-Qiang·2012·Biomaterials

Abstract

The delivery of all of administrated chemotherapeutics into tumor cells is an extreme object for tumor targeting therapy to enhance the curative effect and eliminate the side effect. However, until now, the targeting delivery has only partial been realized by passive targeting, which was called "enhanced permeability and retention" effect, and only few targeting delivery system was commercialized. Here, we designed and synthesized a hepatocarcinoma-binding peptide (A54 peptide, which was identified from a phage-display random peptide library) functionalized and PEGylated stearic acid grafted chitosan (A54-PEG-CS-SA) micelles for targeting therapy of doxorubicin. The A54-PEG-CS-SA micelles presented special internalization ability into human hepatoma cells (BEL-7402) when the cells were co-incubated with normal liver cells in vitro, and high distribution ability to liver and hepatoma tissue in vivo. In vitro and in vivo anti-tumor activity results showed that A54-PEG-CS-SA micelles loading doxorubicin treatments suppressed tumor growth more effectively and reduced toxicity compared with commercial adriamycin injection.

Integrity signals

Registry

Crossref · 10.1016/j.biomaterials.2012.08.043

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A54-functionalized PEG-CS-SA micelle exhibits special internalization ability for liver cancer cells in vitro, high distribution in liver and liver cancer tissues in vivo, more effectively inhibits tumor growth, and reduces toxicity.

    “It exhibits special internalization ability for liver cancer cells in vitro, and has a high distribution ability in liver and liver cancer tissues in vivo. It can more effectively inhibit tumor growth and reduce toxicity.223”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [223]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Du, Y.-Z., Cai, L.-L., Liu, P., You, J., Yuan, H., & Hu, F.-Q.
Affiliations
Zhejiang University (CN)
Venue
Biomaterials
Publisher
Elsevier BV
Published
2012-12
Volume
33
Issue
34
Pages
8858-8867
ISSN
0142-9612 (ISSN-L)
OpenAlex
W2007514493
Cited by
54
References
42
Citations by year
2025: 3 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 10 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 1
FWCI
1.95
Type
journal article
Language
en
Open access
closed
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
polymeric micelles, chitosan, PEGylation, doxorubicin, hepatocellular carcinoma, phage display, passive targeting, enhanced permeability and retention effect, BEL-7402 cells, anticancer activity
MeSH terms
Animals, Antibiotics, Antineoplastic, Doxorubicin, Drug Carriers, Carcinoma, Hepatocellular, Humans, Liver, Liver Neoplasms, Mice, Inbred BALB C, Mice, Nude, Micelles, Oligopeptides, Polyethylene Glycols, Stearic Acids, Drug Delivery Systems, Cell Line, Tumor, Chitosan, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review