Gadolinium-loaded calcium phosphate nanoparticles for magnetic resonance imaging of orthotopic hepatocarcinoma and primary hepatocellular carcinoma
Abstract
Schematic illustration of the formation and the MR imaging effect of A54-CaPNPs.
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A54-TPGS combined with calcium phosphate nanoparticles has higher tumor tissue homing characteristics and longer tumor tissue residence time.
“Zhang et al. have synthesized A54-TPGS (Polyethylene glycol 1000 vitamin E succinate) through esterification, and combined with calcium phosphate nanoparticles to form a multifunctional drug-carrying system, which has higher tumors tissue homing characteristics and longer tumor tissue residence time.222”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [222]
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Smart nanoparticles for cancer therapy
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- Authors
- Zhang, N.-N., Lu, C.-Y., Shu, G.-F., Li, J., Chen, M.-J., Chen, C.-M., Lv, X.-L., Xu, X.-L., Weng, W., Weng, Q.-Y., Tang, B.-F., Du, Y.-Z., & Ji, J.-S.
- Affiliations
- Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research
- Zhejiang University (CN)
- Department of Radiology
- Institute of Pharmaceutics
- Wenzhou Medical University (CN)
- Corresponding author
- Du, Yong-Zhong
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2020
- Volume
- 8
- Issue
- 7
- Pages
- 1961-1972
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W3002822358
- Cited by
- 25
- References
- 36
- Citations by year
- 2025: 6 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 3
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81901852, 81901848)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- MRI contrast agents, hepatocellular carcinoma, T1 relaxivity, BEL-7402 cells
- MeSH terms
- Animals, Calcium Phosphates, Contrast Media, Female, Gadolinium, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Magnetic Resonance Imaging, Male, Neoplasm Transplantation, Particle Size, Cell Line, Tumor, Mice, Nanoparticles, Early Detection of Cancer, Hep G2 Cells, Cell-Penetrating Peptides
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