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Cited by 147Bone Tissue Engineering MaterialsTissue Engineering and Regenerative MedicineBone health and osteoporosis research

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Bone regeneration with BMP-2 delivered from keratose scaffolds

de Guzman, Roche C., Saul, Justin M., Ellenburg, Mary D., Merrill, Michelle R., Coan, Heather B., Smith, Thomas L., Van Dyke, Mark E.·2013·Biomaterials
DOI 10.1016/j.biomaterials.2012.11.002
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Abstract

Infuse(®) is used clinically to promote bone repair. Its efficacy is dependent on a crosslinked collagen carrier/scaffold system that has come under scrutiny due to an inability to control BMP-2 release, which may result in unwanted outcomes such as heterotopic ossification. In this study, keratose biomaterial was evaluated as a new carrier/scaffold. Keratose was mixed with BMP-2, fabricated into a scaffold, and implanted into a critical-size rat femoral defect. This construct showed bridging as early as 4 weeks and induced trabecular morphology characteristic of a remodeling hard fracture callus at 16 weeks. Compared to the normal cortical bone, the regenerated tissue had greater volume and mineral content but less density and ultimate shear stress values. Moreover, μ-CT, biomechanics, FTIR-ATR spectroscopy, and polarized light microscopy data showed regeneration using keratose was similar to an Infuse control. However, unlike Infuse's collagen carrier system, in vitro analysis showed that BMP-2 release correlated with keratose scaffold degradation. Surprisingly, treatment with keratose only led to deposition of more bone outgrowth than the untreated negative control at the 8-week time point. The application of keratose also demonstrated a notable reduction of adipose tissues within the gap. While not able to induce osteogenesis on its own, keratose may be the first biomaterial capable of suppressing adipose tissue formation, thereby indirectly enhancing bone regeneration.

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Crossref · 10.1016/j.biomaterials.2012.11.002

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Citations

Cites

Research works printed but not linked: 2

  1. Schwartz, 2006, Segmental bone defects treated using recombinant human bone morphogenetic protein, J Orthop, 3, e2
  2. Mann, 1989, Bone healing, Semin Vet Med Surg, 4, 312

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Metadata

Authors
de Guzman, R. C., Saul, J. M., Ellenburg, M. D., Merrill, M. R., Coan, H. B., Smith, T. L., & Van Dyke, M. E.
Affiliations
  • Miami University (US)
  • Wake Forest University Health Sciences (US)
ORCID
Venue
Biomaterials
Publisher
Elsevier BV
Published
2013-02
Volume
34
Issue
6
Pages
1644-1656
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2012.11.002
OpenAlex
W2024743274
Cited by
147
References
45
Citations by year
2026: 2 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 15 · 2019: 13 · 2018: 16 · 2017: 19 · 2016: 14 · 2015: 12 · 2014: 13 · 2013: 7
FWCI
5.83
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • US Army
  • KeraNetics, LLC
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
bone regeneration, BMP-2, keratosis, bone graft substitutes, scaffold degradation, critical-size femoral defect, heterotopic ossification, trabecular bone remodeling, bone biomechanics, collagen carrier
MeSH terms
Animals, Biomechanical Phenomena, Bone and Bones, Regeneration, Spectrophotometry, Infrared, Rats, Tissue Scaffolds, Bone Morphogenetic Protein 2

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