Cited by 190Tissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applicationsOsteoarthritis Treatment and Mechanisms

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The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs

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Rowland, Christopher R., Lennon, Donald P., Caplan, Arnold I., Guilak, Farshid·2013·Biomaterials

DOI 10.1016/j.biomaterials.2013.04.027PMC PMC3660461

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Abstract

Scaffolds fabricated from cartilage extracellular matrix provide a chondroinductive environment that stimulates cartilaginous matrix synthesis in a variety of cell types. A limitation of these cartilage-derived matrix (CDM) scaffolds is that they contract during in vitro culture, which unpredictably alters their shape. The current study examined the hypothesis that collagen crosslinking techniques could inhibit cell-mediated contraction of CDM scaffolds. We analyzed the effects of dehydrothermal (DHT) treatment, ultraviolet light irradiation (UV), and the chemical crosslinker carbodiimide (CAR) on scaffold contraction and chondrogenic differentiation of adult human bone marrow-derived stem cells (MSCs). Both physical and chemical crosslinking treatments retained the original scaffold dimensions. DHT and UV treatments produced significantly higher glycosaminoglycan and collagen contents than CAR crosslinked and non-crosslinked constructs. Crosslinking treatments influenced the composition of newly synthesized matrix, and DHT treatment best matched the composition of native cartilage. DHT, UV, and non-crosslinked CDM films supported cell attachment, while CAR crosslinking inhibited cell adhesion. These results affirm that collagen crosslinking treatments can prevent cell-mediated contraction of CDM scaffolds. Interestingly, crosslinking treatments influence chondrogenic differentiation. These effects seem to be mediated by modifications to cell-matrix interactions between MSCs and the CDM; however, further work is necessary to elucidate the specific mechanisms involved in this process.

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Authors: Rowland, C. R., Lennon, D. P., Caplan, A. I., & Guilak, F.
Affiliations: Duke Medical Center (US)
Case Western Reserve University (US)
Corresponding author: Guilak, Farshid
ORCID: Rowland, Christopher R.
Caplan, Arnold I.
Guilak, Farshid
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2013-07
Volume: 34
Issue: 23
Pages: 5802-5812
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2013.04.027
PMC: PMC3660461
OpenAlex: W2021219047
Cited by: 190
References: 70
Citations by year: 2026: 6 · 2025: 4 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 18 · 2020: 14 · 2019: 23 · 2018: 18 · 2017: 12 · 2016: 16 · 2015: 22 · 2014: 14 · 2013: 3
FWCI: 16.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (AG 15768, R01AG015768)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 50245, AR48182, AR-48852, P01AR050245, R01AR048852, P01AR053622, AR53622, R01AR048182)
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: collagen cross-linking, chondrogenic differentiation, mesenchymal stem cells, dehydrothermal treatment, UV irradiation, carbodiimide crosslinking, cell adhesion, cell-matrix interactions, glycosaminoglycans, collagen, cartilage tissue engineering
MeSH terms: Adult, Animals, Cartilage, Cell Adhesion, Cell Differentiation, Collagen, Cross-Linking Reagents, DNA, Extracellular Matrix, Female, Glycosaminoglycans, Humans, Immunohistochemistry, Porosity, Chondrogenesis, Tissue Engineering, Sus scrofa, Green Fluorescent Proteins, Transforming Growth Factor beta3, Tissue Scaffolds, Mesenchymal Stem Cells

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The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs

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