Cited by 286Metal-Organic Frameworks: Synthesis and ApplicationsNanoparticle-Based Drug DeliveryMesoporous Materials and Catalysis

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Positioning metal-organic framework nanoparticles within the context of drug delivery – A comparison with mesoporous silica nanoparticles and dendrimers

Wuttke, Stefan, Lismont, Marjorie, Escudero, Alberto, Rungtaweevoranit, Bunyarat, Parak, Wolfgang J.·2017·Biomaterials

DOI 10.1016/j.biomaterials.2017.01.025

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Abstract

Nanotechnology enables the creation of delivery vehicles able to overcome physiologically imposed barriers, allowing new approaches for reducing the unwanted side effects of systemic delivery of drug, increasing targeting efficiency and so improving therapy efficacy. Owing to the considerable advances in material sciences and pharmaceutics, a broad range of different inorganic or organic drug nanocarriers have been developed. Furthermore, researchers have shown that the combination of inorganic and organic chemistries in one single material, named metal-organic framework (MOF), offers structural designability at the molecular level together with tunable porosity and chemical functionalisability. While the MOF size can be controlled at the nanometer scale, these features are of paramount interest in the development of the next generation of drug delivery systems. After a short state-of-the-art about MOF technology and within the drug delivery context, this paper discusses the benefits of using MOF nanoparticles compared to dendrimers and mesoporous silica nanoparticles in order to understand the challenges that must still be overcome.

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Background

Authors: Wuttke, S., Lismont, M., Escudero, A., Rungtaweevoranit, B., & Parak, W. J.
Affiliations: Center for NanoScience (DE)
University of Liège (BE)
Philipps University of Marburg (DE)
Kavli Energy NanoScience Institute (US)
Corresponding author: Wuttke, Stefan
Parak, Wolfgang J.
ORCID: Wuttke, Stefan
Escudero, Alberto
Rungtaweevoranit, Bunyarat
Parak, Wolfgang J.
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2017-04
Volume: 123
Pages: 172-183
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2017.01.025
OpenAlex: W2580236852
Cited by: 286
References: 196
Citations by year: 2026: 13 · 2025: 30 · 2024: 15 · 2023: 24 · 2022: 22 · 2021: 31 · 2020: 32 · 2019: 50 · 2018: 54 · 2017: 15
FWCI: 15.79
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Deutsche Forschungsgemeinschaft (WU 622/4-1)
University of Liège, Belgium (CRA2015)
Topics: Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Organic Frameworks: Synthesis and Applications
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
Keywords: metal-organic frameworks, drug delivery, mesoporous silica nanoparticles, dendrimers, drug nanocarriers, nanoparticle drug delivery, tunable porosity, chemical functionalization, targeted drug delivery
MeSH terms: Metal-Organic Frameworks, Diffusion, Particle Size, Silicon Dioxide, Porosity, Dendrimers, Nanocapsules, Nanopores, Absorption, Physicochemical

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Positioning metal-organic framework nanoparticles within the context of drug delivery – A comparison with mesoporous silica nanoparticles and dendrimers

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