The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
When stem cells meet graphene: Opportunities and challenges in regenerative medicine
Open accessAbstract
Recent advances in stem cell research and nanotechnology have significantly influenced the landscape of tissue engineering and regenerative medicine. Precise and reproducible control of the fate of stem cells and their lineage specification have, therefore, become more crucial than ever for the success of stem cell-based technologies. Extensive research has been geared towards developing materials that are capable of mimicking the physiological microenvironment of stem cells and at the same time, controlling their eventual fate. An interesting example of these materials is two-dimensional graphene and its related derivatives. A high specific surface area coupled with superior chemical stability, biocompatibility, and flexibility in functionalization render graphene-based nanomaterials one of the most exciting platforms for tissue engineering and regenerative medicine applications, especially for stem cell growth, proliferation, and differentiation. In this review, we discuss the love-hate relationship between stem cells and graphene-based nanomaterials in tissue engineering and regenerative medicine. We first discuss the role and importance of stem cells in tissue engineering and regenerative medicine. We then highlight the use of nanomaterials for stem cell control, the interaction between stem cells and graphene nanomaterials as well as their biocompatibility, biodistribution, and biodegradability considerations. We also offer our perspectives on the various challenges and opportunities facing the use of graphene and its derivatives for stem cell growth and differentiation.
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Cites
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Cited by
Zhang, X., Chen, X., Hong, H., Hu, R., Liu, J., & Liu, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.014 · Cited by 680
Graphene and graphene oxide as nanomaterials for medicine and biology application
Priyadarsini, S., Mohanty, S., Mukherjee, S., Basu, S., & Mishra, M. (2018) · Journal of Nanostructure in Chemistry · doi:10.1007/s40097-018-0265-6 · Cited by 570
Review of hybrid PLGA nanoparticles: Future of smart drug delivery and theranostics medicine
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Metadata
- Authors
- Kenry, Lee, W. C., Loh, K. P., & Lim, C. T.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 155
- Pages
- 236-250
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2763815711
- Cited by
- 293
- References
- 156
- FWCI
- 15.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kenry, Lee, W. C., Loh, K. P., & Lim, C. T. (2018). When stem cells meet graphene: Opportunities and challenges in regenerative medicine. Biomaterials. https://doi.org/10.1016/j.biomaterials.2017.10.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
