The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents
Open accessAbstract
Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro. In vivo, the resulting paclitaxel-SPION-co-loaded PEG-PE micelles retained their Magnetic Resonance contrast properties and apoptotic activity in breast and melanoma tumor mouse models. Such theranostic systems are likely to play a significant role in the combined diagnosis and therapy that leads to a more personalized and effective form of treatment.
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“Among them, polymeric micelles formed by amphiphilic block copolymers have gained more attention due to their unique properties such as the core/shell structure, excellent stability, and ideal encapsulation and delivery efficiency of hydrophobic drugs.34–37”
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Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565
Imaging in the era of molecular oncology
Weissleder, R., & Pittet, M. J. (2008) · Nature · doi:10.1038/nature06917 · Cited by 2,420
Nanoparticle-based theranostic agents
Xie, J., Lee, S., & Chen, X. S. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.009 · Cited by 1,444
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J. (2006) · Nano Letters · doi:10.1021/nl061412u · Cited by 1,238
Barriers to Drug Delivery in Solid Tumors
Jain, R. K. (1994) · Scientific American · doi:10.1038/scientificamerican0794-58 · Cited by 1,074
Superparamagnetic iron oxide: pharmacokinetics and toxicity
Weissleder, R., Stark, D., Engelstad, B. L., Bacon, B., Compton, C. C., White, D., Jacobs, P. M., & Lewis, J. M. (1989) · American Journal of Roentgenology · doi:10.2214/ajr.152.1.167 · Cited by 1,045
Gold, R., Schmied, M. C., Giegerich, G., Breitschopf, H., Hartung, H., Toyka, K. V., & Lassmann, H. (1994) · PubMed · Cited by 675
Yu, M. K., Jeong, Y. Y., Park, J., Park, S.-J., Kim, J. W., Min, J. J., Kim, K., & Jon, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800857 · Cited by 621
Surface-Engineered Magnetic Nanoparticle Platforms for Cancer Imaging and Therapy
Xie, J., Liu, G., Eden, H. S., Ai, H., & Chen, X. S. (2011) · Accounts of Chemical Research · doi:10.1021/ar200044b · Cited by 582
Sanson, C., Diou, O., Thévenot, J., Ibarboure, E., Soum, A. H., Brûlet, A., Miraux, S., Thiaudière, E., Tan, S., Brisson, A. R., et al. (2011) · ACS Nano · doi:10.1021/nn102762f · Cited by 506
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Theranostic Applications of Functionalized Polymeric Micelles
Aiwale, B. S., Deore, M. S., Jain, K., & Naqvi, S. (2023) · Springer eBooks · doi:10.1007/978-981-99-0538-6_13
Theranostic polymeric micelles mediated drug delivery
Maddila, J. R., Murugaiyan, K., Saha, S., & Rengan, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22044-9.00004-8
Functional Magnetic Solid Lipid Nanoparticles for Theranostic Applications
Raut, S. Y., Vitore, J. G., Alandikar, P., Singh, S., Jadhav, R., Benival, D. M., & Giram, P. S. (2024) · Wiley eBooks · doi:10.1002/9781394172917.ch7
Patel, Y. H., Ranch, K. M., Jani, H., Patel, C. R., Jacob, S., Mohamed, M. R., & Boddu, S. H. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-36453-2.00012-4
Recent advances in paclitaxel polymer nanomedicine delivery for cancer therapy
Zhang, Y., Liu, H., Zhen, W., Jiang, T., & Cui, J. (2026) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902026e24609
Metadata
- Authors
- Upponi, J. R., Jerajani, K., Nagesha, D. K., Kulkarni, P., Sridhar, S., Ferris, C., & Torchilin, V. P.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Torchilin, Vladimir P.
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 170
- Pages
- 26-36
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC5918157
- OpenAlex
- W2794954838
- Cited by
- 105
- References
- 52
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 25 · 2019: 21 · 2018: 5
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1RO1CA121838, 1U54CA151881)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- polymeric micelles, theranostics, co-delivery, paclitaxel, superparamagnetic iron oxide nanoparticles, MRI contrast agents, poorly water-soluble drugs, cancer diagnosis and treatment, breast cancer, melanoma, apoptosis
- MeSH terms
- Theranostic Nanomedicine, Animals, Contrast Media, Female, Magnetic Resonance Imaging, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Micelles, Neoplasms, Polymers, Solubility, Water, Drug Delivery Systems, Apoptosis, Paclitaxel, Cell Line, Tumor, Magnetite Nanoparticles
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