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Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents
Open accessAbstract
Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro. In vivo, the resulting paclitaxel-SPION-co-loaded PEG-PE micelles retained their Magnetic Resonance contrast properties and apoptotic activity in breast and melanoma tumor mouse models. Such theranostic systems are likely to play a significant role in the combined diagnosis and therapy that leads to a more personalized and effective form of treatment.
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“Among them, polymeric micelles formed by amphiphilic block copolymers have gained more attention due to their unique properties such as the core/shell structure, excellent stability, and ideal encapsulation and delivery efficiency of hydrophobic drugs.34–37”
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Cites
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review
Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565
Imaging in the era of molecular oncology
Weissleder, R., & Pittet, M. J. (2008) · Nature · doi:10.1038/nature06917 · Cited by 2,420
Nanoparticle-based theranostic agents
Xie, J., Lee, S., & Chen, X. S. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.009 · Cited by 1,444
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J. (2006) · Nano Letters · doi:10.1021/nl061412u · Cited by 1,238
Barriers to Drug Delivery in Solid Tumors
Jain, R. K. (1994) · Scientific American · doi:10.1038/scientificamerican0794-58 · Cited by 1,074
Superparamagnetic iron oxide: pharmacokinetics and toxicity
Weissleder, R., Stark, D., Engelstad, B. L., Bacon, B., Compton, C. C., White, D., Jacobs, P. M., & Lewis, J. M. (1989) · American Journal of Roentgenology · doi:10.2214/ajr.152.1.167 · Cited by 1,045
Gold, R., Schmied, M. C., Giegerich, G., Breitschopf, H., Hartung, H., Toyka, K. V., & Lassmann, H. (1994) · PubMed · Cited by 675
Yu, M. K., Jeong, Y. Y., Park, J., Park, S.-J., Kim, J. W., Min, J. J., Kim, K., & Jon, S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200800857 · Cited by 621
Surface-Engineered Magnetic Nanoparticle Platforms for Cancer Imaging and Therapy
Xie, J., Liu, G., Eden, H. S., Ai, H., & Chen, X. S. (2011) · Accounts of Chemical Research · doi:10.1021/ar200044b · Cited by 582
Sanson, C., Diou, O., Thévenot, J., Ibarboure, E., Soum, A. H., Brûlet, A., Miraux, S., Thiaudière, E., Tan, S., Brisson, A. R., et al. (2011) · ACS Nano · doi:10.1021/nn102762f · Cited by 506
Development and applications of photo-triggered theranostic agents
Rai, P., Mallidi, S., Zheng, X., Rahmanzadeh, R., Mir, Y., Elrington, S. A., Khurshid, A., & Hasan, T. G. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.09.002 · Cited by 506
Nanoparticles as contrast agents for in-vivo bioimaging: current status and future perspectives
Hahn, M. A., Singh, A. K., Sharma, P., Brown, S. C., & Moudgil, B. M. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-4207-5 · Cited by 495
Magnetite-loaded polymeric micelles as ultrasensitive magnetic-resonance probes
Ai, H., Flask, C., Weinberg, B., Shuai, X. ‐., Pagel, M. D., Farrell, D., Duerk, J., & Gao, J. (2005) · Advanced Materials · doi:10.1002/adma.200401904 · Cited by 465
Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy
Dilnawaz, F., Singh, A., Mohanty, C., & Sahoo, S. K. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.057 · Cited by 385
Targeting cancer cells: magnetic nanoparticles as drug carriers
Alexiou, C., Schmid, R. J., Jurgons, R., Kremer, M., Wanner, G., Bergemann, C., Huenges, E., Nawroth, T., Arnold, W. J., & Parak, F. (2006) · European Biophysics Journal · doi:10.1007/s00249-006-0042-1 · Cited by 362
Micellar Hybrid Nanoparticles for Simultaneous Magnetofluorescent Imaging and Drug Delivery
Park, J., von Maltzahn, G., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801810 · Cited by 336
Yang, X., Grailer, J. J., Rowland, I. J., Javadi, A., Hurley, S. A., Matson, V. Z., Steeber, D. A., & Gong, S. (2010) · ACS Nano · doi:10.1021/nn101670k · Cited by 324
Wang, A. Z., Bagalkot, V., Vassiliou, C. C., Gu, F., Alexis, F., Zhang, L., Shaikh, M. R., Yuet, K. P., Cima, M. J., Langer, R., et al. (2008) · ChemMedChem · doi:10.1002/cmdc.200800091 · Cited by 317
Nitin, N., LaConte, L. E. W., Zurkiya, O., Hu, X. P., & Bao, G. (2004) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-004-0560-1 · Cited by 296
Diacyllipid-Polymer Micelles as Nanocarriers for Poorly Soluble Anticancer Drugs
Gao, Z., Lukyanov, A. N., Singhal, A., & Torchilin, V. P. (2002) · Nano Letters · doi:10.1021/nl025604a · Cited by 262
Self-citationNanoparticulates as Drug Carriers
Torchilin, V. P. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/p432 · Cited by 247
Self-citationMultifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging
Yang, X., Grailer, J. J., Rowland, I. J., Javadi, A., Hurley, S. A., Steeber, D. A., & Gong, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.039 · Cited by 224
Talelli, M., Rijcken, C. J. F., Lammers, T., Seevinck, P. R., Storm, G., van Nostrum, C. F., & Hennink, W. E. (2009) · Langmuir · doi:10.1021/la8036499 · Cited by 210
Thermoresponsive core–shell magnetic nanoparticles for combined modalities of cancer therapy
Purushotham, S., Chang, J. P.-E., Rumpel, H., Kee, I. H. C., Ng, R. T. H., Chow, P. K. H., Tan, C., & Ramanujan, R. V. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/30/305101 · Cited by 201
Polymeric nanomedicine for cancer MR imaging and drug delivery
Khemtong, C., Kessinger, C. W., & Gao, J. (2009) · Chemical Communications · doi:10.1039/b821865j · Cited by 186
Interaction of Functionalized Superparamagnetic Iron Oxide Nanoparticles with Brain Structures
Cengelli, F., Maysinger, D., Monnet‐Tschudi, F., Montet, X., Corot, C., Petri‐Fink, A., Hofmann, H., & Juillerat‐Jeanneret, L. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101915 · Cited by 178
Kaaki, K., Hervé-Aubert, K., Chiper, M., Shkilnyy, A., Soucé, M., Benoit, R., Paillard, A., Dubois, P., Saboungi, M., & Chourpa, I. (2011) · Langmuir · doi:10.1021/la2037845 · Cited by 122
Gao, G., Lee, J. W., Nguyen, M. K., Im, G. H., Yang, J., Heo, H., Jeon, P., Park, T. G., Lee, D. S., & Lee, D. S. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.09.012 · Cited by 117
Cho, E.-A., Moloney, F. J., Cai, H., Au-Yeung, A., China, C., Scolyer, R. A., Yosufi, B., Raftery, M. J., Deng, J. Z., Morton, S. W., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62166-7 · Cited by 111
He, X., Wu, X., Cai, X., Lin, S., Xie, M., Zhu, X., & Yan, D. (2012) · Langmuir · doi:10.1021/la302546m · Cited by 109
Chandrasekharan, P., Maity, D., Yong, C., Chuang, K., Ding, J., & Feng, S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.037 · Cited by 101
Synthesis and characterization of pH-sensitive glycopolymers for oral drug delivery systems
Kim, B., & Peppas, N. A. (2002) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856202320893000 · Cited by 99
Multifunctional polymer vesicles for ultrasensitive magnetic resonance imaging and drug delivery
Ren, T., Liu, Q., Lu, H., Liu, H., Zhang, X., & Du, J. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm31891a · Cited by 84
Enhanced cytotoxicity of TATp-bearing paclitaxel-loaded micelles in vitro and in vivo
Sawant, R. R., & Torchilin, V. P. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.02.022 · Cited by 79
Self-citationWu, E. X., Tang, H., & Jensen, J. H. (2004) · NMR in Biomedicine · doi:10.1002/nbm.923 · Cited by 79
Gang, J., Park, S.-B., Hyung, W., Choi, E. H., Wen, J., Kim, H.-S., Shul, Y., Haam, S., & Song, S. Y. (2007) · Journal of drug targeting · doi:10.1080/10611860701453901 · Cited by 75
Nanoparticulates as Drug Carriers
(2007) · Nano Today · doi:10.1016/s1748-0132(07)70060-9 · Cited by 75
Campbell, J. L., Arora, J. K., Cowell, S. F., Garg, A., Eu, P., Bhargava, S. K., & Bansal, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021857 · Cited by 68
Rastogi, R., Gulati, N., Kotnala, R. K., Sharma, U., Jayasundar, R., & Koul, V. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.08.037 · Cited by 67
Anirudhan, T. S., & Sandeep, S. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm31794j · Cited by 64
Andhariya, N., Chudasama, B., Mehta, R. V., & Upadhyay, R. V. (2010) · Journal of Nanoparticle Research · doi:10.1007/s11051-010-9921-6 · Cited by 63
Breast MRI: Fundamentals and Technical Aspects
Hendee, W. R. (2008) · Medical Physics · doi:10.1118/1.2840347 · Cited by 62
Nagesha, D. K., Plouffe, B. D., Phan, M. N., Lewis, L. H., Sridhar, S., & Murthy, S. K. (2009) · Journal of Applied Physics · doi:10.1063/1.3073654 · Cited by 61
Self-citationWu, X., He, X., Zhong, L., Lin, S., Wang, D., Zhu, X., & Yan, D. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm11613d · Cited by 59
Sawant, R. R., & Torchilin, V. P. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-609-2_9 · Cited by 58
Self-citationFormulation of novel lipid-coated magnetic nanoparticles as the probe for in vivo imaging
Huang, H.-C., Chang, P., Chang, K., Chen, K., Lin, C., Chen, J., Mou, C., Chang, Z.-F., & Chang, F. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-86 · Cited by 58
Sun, Q., Cheng, D., Yu, X., Zhang, Z., Dai, J., Li, H., Liang, B., & Shuai, X. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm12404h · Cited by 50
Monitoring of Magnetic Targeting to Tumor Vasculature Through MRI and Biodistribution
Gultepe, E., Reynoso, F. J., Jhaveri, A. M., Kulkarni, P. P., Nagesha, D. K., Ferris, C. F., Harisinghani, M. G., Campbell, R. B., & Sridhar, S. (2010) · Nanomedicine · doi:10.2217/nnm.10.84 · Cited by 47
Self-citationChen, D., Xia, X., Gu, H., Xu, Q., Ge, J., Li, Y., Li, N., & Lu, J. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm11195g · Cited by 44
Sawant, R., Sawant, R. R., Gultepe, E., Nagesha, D. K., Papahadjopoulos‐Sternberg, B., Sridhar, S., & Torchilin, V. P. (2009) · Journal of Nanoparticle Research · doi:10.1007/s11051-009-9611-4 · Cited by 41
Self-citationTheranostic agents that co-deliver therapeutic and imaging agents?
MacKay, J. A., & Li, Z. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.10.001 · Cited by 29
First-in-human trial of Dz13 for nodular basal-cell carcinoma
Grassi, G., & Grassi, M. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60633-9 · Cited by 10
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Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures
Khan, N. H., Mir, M., Qian, L., Baloch, M., Khan, M. F. A., Rehman, A. U., Ngowi, E. E., Wu, D., & Ji, X. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.06.014 · Cited by 254
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Metadata
- Authors
- Upponi, J. R., Jerajani, K., Nagesha, D. K., Kulkarni, P., Sridhar, S., Ferris, C., & Torchilin, V. P.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Torchilin, Vladimir P.
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 170
- Pages
- 26-36
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC5918157
- OpenAlex
- W2794954838
- Cited by
- 105
- References
- 52
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 25 · 2019: 21 · 2018: 5
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1RO1CA121838, 1U54CA151881)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- polymeric micelles, theranostics, co-delivery, paclitaxel, superparamagnetic iron oxide nanoparticles, MRI contrast agents, poorly water-soluble drugs, cancer diagnosis and treatment, breast cancer, melanoma, apoptosis
- MeSH terms
- Theranostic Nanomedicine, Animals, Contrast Media, Female, Magnetic Resonance Imaging, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Micelles, Neoplasms, Polymers, Solubility, Water, Drug Delivery Systems, Apoptosis, Paclitaxel, Cell Line, Tumor, Magnetite Nanoparticles
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