Cited by 105Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsUltrasound and Hyperthermia Applications

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Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents

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Upponi, Jaydev R., Jerajani, Kaushal, Nagesha, Dattatri K., Kulkarni, Praveen, Sridhar, Srinivas, Ferris, Craig, Torchilin, Vladimir P.·2018·Biomaterials

DOI 10.1016/j.biomaterials.2018.03.054PMC PMC5918157

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Abstract

Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro. In vivo, the resulting paclitaxel-SPION-co-loaded PEG-PE micelles retained their Magnetic Resonance contrast properties and apoptotic activity in breast and melanoma tumor mouse models. Such theranostic systems are likely to play a significant role in the combined diagnosis and therapy that leads to a more personalized and effective form of treatment.

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Authors: Upponi, J. R., Jerajani, K., Nagesha, D. K., Kulkarni, P., Sridhar, S., Ferris, C., & Torchilin, V. P.
Affiliations: Northeastern University (US)
Corresponding author: Torchilin, Vladimir P.
ORCID: Jerajani, Kaushal
Nagesha, Dattatri K.
Kulkarni, Praveen
Sridhar, Srinivas
Ferris, Craig
Torchilin, Vladimir P.
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2018-07
Volume: 170
Pages: 26-36
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2018.03.054
PMC: PMC5918157
OpenAlex: W2794954838
Cited by: 105
References: 52
Citations by year: 2026: 2 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 25 · 2019: 21 · 2018: 5
FWCI: 5.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (1RO1CA121838, 1U54CA151881)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Keywords: polymeric micelles, theranostics, co-delivery, paclitaxel, superparamagnetic iron oxide nanoparticles, MRI contrast agents, poorly water-soluble drugs, cancer diagnosis and treatment, breast cancer, melanoma, apoptosis
MeSH terms: Theranostic Nanomedicine, Animals, Contrast Media, Female, Magnetic Resonance Imaging, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Micelles, Neoplasms, Polymers, Solubility, Water, Drug Delivery Systems, Apoptosis, Paclitaxel, Cell Line, Tumor, Magnetite Nanoparticles

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Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents

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