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Cited by 570

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

Wu, Jiangyi, Kuang, Liang, Chen, Cheng, Yang, Junjun, Zeng, Wei-Nan, Li, Tao, Chen, Hao, Huang, Shu, Fu, Zhenlan, Li, Jiamiao, Liu, Renfeng, Ni, Zhenhong, Chen, Lin, Yang, Liu·2019·Biomaterials
DOI 10.1016/j.biomaterials.2019.03.022
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Abstract

Osteoarthritis (OA) is the most common disabling joint disease throughout the world and its therapeutic effect is still not satisfactory in clinic nowadays. Recent studies showed that the exosomes derived from several types of mesenchymal stem cells (MSCs) could maintain chondrocyte homeostasis and ameliorate the pathological severity of OA in animal models, indicating that MSCs-derived exosomes could be a novel promising strategy for treating OA. In this study, we investigated the role and underlying mechanisms of infrapatellar fat pad (IPFP) MSCs-derived exosomes (MSCIPFP-Exos) on OA in vitro and in vivo. Our data revealed that MSCIPFP could produce amounts of MSCIPFP-Exos, which exhibited the typical morphological features of exosomes. The MSCIPFP-Exos ameliorated the OA severity in vivo and inhibited cell apoptosis, enhanced matrix synthesis and reduced the expression of catabolic factor in vitro. Moreover, MSCIPFP-Exos could significantly enhance autophagy level in chondrocytes partially via mTOR inhibition. Exosomal RNA-seq showed that the level of miR-100-5p that could bind to the 3'-untranslated region (3'UTR) of mTOR was the highest among microRNAs. MSCIPFP-Exos decreased the luciferase activity of mTOR 3'UTR, while inhibition of miR-100-5p could reverse the MSCIPFP-Exos-decreased mTOR signaling pathway. Intra-articular injection of antagomir-miR-100-5p dramatically attenuated MSCIPFP-Exos-mediated protective effect on articular cartilage in vivo. In brief, MSCIPFP-derived exosomes protect articular cartilage from damage and ameliorate gait abnormality in OA mice by maintaining cartilage homeostasis, the mechanism of which may be related to miR100-5p-regulated inhibition of mTOR-autophagy pathway. As it is relatively feasible to obtain human IPFP from OA patients by arthroscopic operation in clinic, MSCIPFP-derived exosomes may be a potential therapy for OA in the future.

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Metadata

Authors
Wu, J., Kuang, L., Chen, C., Yang, J., Zeng, W.-N., Li, T., Chen, H., Huang, S., Fu, Z., Li, J., Liu, R., Ni, Z., Chen, L., & Yang, L.
Venue
Biomaterials
Publisher
Elsevier BV
Published
2019-06
Volume
206
Pages
87-100
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2019.03.022
OpenAlex
W2923441281
Cited by
570
References
11
FWCI
41.11
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis. https://app.cochat.ai/papers/10.1016/j.biomaterials.2019.03.022
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Wu, J., Kuang, L., Chen, C., Yang, J., Zeng, W.-N., Li, T., Chen, H., Huang, S., Fu, Z., Li, J., Liu, R., Ni, Z., Chen, L., & Yang, L. (2019). miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis. Biomaterials. https://doi.org/10.1016/j.biomaterials.2019.03.022

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.