Engineering a biomimetic bone scaffold that can regulate redox homeostasis and promote osteogenesis to repair large bone defects
Abstract
The reconstruction of a large bone defect to an extent that exceeds its self-healing capacity has been a great clinical challenge. In pursuit of this goal, a biomaterial-based scaffold that comprises radially aligned mineralized collagen (RA-MC) fibers that incorporate nanosilicon (RA-MC/nSi), is proposed. The chemical composition of the MC fibers is similar to that of natural bone matrices. The therapeutic efficacy of the RA-MC/nSi scaffold is evaluated in a mouse model with an experimentally created large calvarial defect. In vitro and in vivo results reveal that the RA-MC fibers of the scaffold guide the directional infiltration and migration of reparative cells from the host tissue toward the center of the defect, suggesting a potential application in promoting osteoconductivity. The incorporated nSi renders the scaffold able sustainably to release gaseous hydrogen and water-soluble silicic acid during the healing process. The released hydrogen gas can effectively regulate redox homeostasis and mitigate excessive inflammation, and the silicic acid can promote the proliferation of reparative cells and enhance their osteogenic differentiation, indicative of osteoinductivity. These findings support the use of the as-proposed biomimetic RA-MC/nSi scaffold as a promising bone substitute to enhance the regeneration of large bone defects.
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Repair of large-sized bone defects resulting from severe injury, open fractures, bacterial infections, tumor resection, or congenital genetic disorders constitutes a global clinical challenge.
“Repair of large-sized bone defects resulting from severe injury, open fractures, bacterial infections, tumor resection, or congenital genetic disorders constitutes a global clinical challenge [[1], [2], [3]].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [3]
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- Authors
- Mac, C.-H., Chan, H.-Y., Lin, Y.-H., Sharma, A. K., Song, H.-L., Chan, Y.-S., Lin, K.-J., Lin, Y.-J., & Sung, H.-W.
- Affiliations
- National Tsing Hua University (TW)
- National Taiwan University Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- Chang Gung University (TW)
- Corresponding author
- Lin, Kun-Ju
- Lin, Yu-Jung
- Sung, Hsing-Wen
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 286
- Pages
- 121574
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W4280613369
- Cited by
- 60
- References
- 46
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 16 · 2023: 16 · 2022: 1
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chang Gung Memorial Hospital Linkou (CORPG3L0071)
- Ministry of Education (MOE 110QR001I5)
- Ministry of Science and Technology (110-2639-E-007-001- ASP, 110-2634-F-007-023)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- bone scaffolds, nano-silicon, hydrogen release, silicic acid, redox homeostasis, bone formation, calvarial defect, osteoconductivity, osteoinductivity, inflammation reduction, bone regeneration, biomimetic biomaterials
- MeSH terms
- Animals, Bone Regeneration, Cell Differentiation, Collagen, Homeostasis, Hydrogen, Osteogenesis, Oxidation-Reduction, Silicic Acid, Tissue Engineering, Biomimetics, Mice, Tissue Scaffolds
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