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Cited by 1,301Antioxidant Activity and Oxidative StressExercise and Physiological ResponsesRedox biology and oxidative stress

Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants

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Poljsak, Borut, Šuput, Dušan, Milisav, Irina·2013·Oxidative Medicine and Cellular Longevity
DOI 10.1155/2013/956792PMC PMC3657405
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Abstract

Free radical damage is linked to formation of many degenerative diseases, including cancer, cardiovascular disease, cataracts, and aging. Excessive reactive oxygen species (ROS) formation can induce oxidative stress, leading to cell damage that can culminate in cell death. Therefore, cells have antioxidant networks to scavenge excessively produced ROS. The balance between the production and scavenging of ROS leads to homeostasis in general; however, the balance is somehow shifted towards the formation of free radicals, which results in accumulated cell damage in time. Antioxidants can attenuate the damaging effects of ROS in vitro and delay many events that contribute to cellular aging. The use of multivitamin/mineral supplements (MVMs) has grown rapidly over the past decades. Some recent studies demonstrated no effect of antioxidant therapy; sometimes the intake of antioxidants even increased mortality. Oxidative stress is damaging and beneficial for the organism, as some ROS are signaling molecules in cellular signaling pathways. Lowering the levels of oxidative stress by antioxidant supplements is not beneficial in such cases. The balance between ROS and antioxidants is optimal, as both extremes, oxidative and antioxidative stress, are damaging. Therefore, there is a need for accurate determination of individual's oxidative stress levels before prescribing the supplement antioxidants.

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Authors
Poljsak, B., Šuput, D., & Milisav, I.
Affiliations
  • University of Ljubljana, Laboratory of Oxidative Stress Research, Faculty of Health Sciences, Zdravstvena Pot 5, SI-1000 Ljubljana, Slovenia
  • University of Ljubljana (SI)
Corresponding author
Milisav, Irina
ORCID
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2013
Volume
2013
Pages
1-11
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
DOI
10.1155/2013/956792
PMC
PMC3657405
OpenAlex
W2019227799
Cited by
1,301
References
9
Citations by year
2026: 48 · 2025: 107 · 2024: 120 · 2023: 191 · 2022: 160 · 2021: 165 · 2020: 115 · 2019: 90 · 2018: 101 · 2017: 86 · 2016: 55 · 2015: 41 · 2014: 18 · 2013: 3
FWCI
3.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
reactive oxygen species, antioxidants, oxidative stress, oxidative damage, multivitamin and mineral supplements, antioxidant supplementation, cellular aging, ROS signaling, degenerative diseases
MeSH terms
Animals, Antioxidants, Humans, Models, Biological, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress

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