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Cited by 126Pesticide Exposure and ToxicityDrug-Induced Hepatotoxicity and ProtectionEnvironmental Toxicology and Ecotoxicology

Antagonistic effects of Spirulina platensis against sub-acute deltamethrin toxicity in mice: Biochemical and histopathological studies

Abdel-Daim, Mohamed, El-Bialy, Badr E., Rahman, Haidy G. Abdel, Radi, Abeer M., Hefny, Hany A., Hassan, Ahmed M.·2016·Biomedicine & Pharmacotherapy
DOI 10.1016/j.biopha.2015.12.003
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Abstract

Spirulina platensis (SP); a microalga with high antioxidant and anti-inflammatory activities, acts as a food supplement in human and as many animal species. Deltamethrin (DLM) is a synthetic pyrethroid with broad spectrum activities against acaricides and insects and widely used for veterinary and agricultural purposes. Exposure to DLM leads to hepatotoxic, nephrotoxic and neurotoxic side effects for human and many species, including birds and fish. The present study was undertaken to examine the potential hepatoprotective, nephroprotective, neuroprotective and antioxidant effects of SP against sub-acute DLM toxicity in male mice. DLM intoxicated animals revealed a significant increase in serum hepatic and renal injury biomarkers as well as TNF-α level and AChE activity. Moreover, liver, kidney and brain lipid peroxidation and oxidative stress markers were altered due to DLM toxicity. Spirulina normalized the altered serum levels of AST, ALT, APL, LDH, γ-GT, cholesterol, uric acid, urea, creatinine AChE and TNF-α. Furthermore, it reduced DLM-induced tissue lipid peroxidation, nitric oxide and oxidative stress in a dose-dependent manner. Collectively, that Spirulina supplementation could overcome DLM-induced hepatotoxicty, nephrotoxicity and neurotoxicity by abolishing oxidative tissue injuries.

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Crossref · 10.1016/j.biopha.2015.12.003

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  • Antioxidant activity accounts for the protective role of Spirulina against toxicity induced by carbon tetrachloride, metals, deltamethrin, and drugs in animal models.

    “It has been suggested that the antioxidant activity accounts for the protective role of Spirulina against the toxicity induced by carbon tetrachloride (CCl4) [40], by metals (arsenic, mercuric chloride, chromium, cadmium, and fluoride) [34, 41–44], by the insecticide deltamethrin in mice [39] and rats [45]”

    From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [39]

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Authors
Abdel-Daim, M., El-Bialy, B. E., Rahman, H. G. A., Radi, A. M., Hefny, H. A., & Hassan, A. M.
Affiliations
  • Beni-Suef University (EG)
  • Suez Canal University (EG)
ORCID
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2016-02
Volume
77
Pages
79-85
ISSN
0753-3322 (ISSN-L)
DOI
10.1016/j.biopha.2015.12.003
OpenAlex
W2197062689
Cited by
126
References
66
Citations by year
2026: 4 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 14 · 2021: 17 · 2020: 18 · 2019: 15 · 2018: 13 · 2017: 14 · 2016: 7 · 2014: 2
FWCI
13.70
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
Keywords
Spirulina platensis, deltamethrin, pyrethroid toxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, hepatoprotection, renal protection, neuroprotective activity, antioxidant activity, lipid peroxidation, oxidative stress, TNF-α, acetylcholinesterase, histopathology, microalgae
MeSH terms
Acetylcholinesterase, Animals, Antioxidants, Brain, Kidney, Liver, Male, Nitriles, Pyrethrins, Tumor Necrosis Factor-alpha, Lipid Peroxidation, Oxidative Stress, Neuroprotective Agents, Dietary Supplements, Mice, Spirulina, Chemical and Drug Induced Liver Injury, Acute Kidney Injury

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