Plant Secondary Metabolites Produced in Response to Abiotic Stresses Has Potential Application in Pharmaceutical Product Development
Open accessAbstract
Plant secondary metabolites (PSMs) are vital for human health and constitute the skeletal framework of many pharmaceutical drugs. Indeed, more than 25% of the existing drugs belong to PSMs. One of the continuing challenges for drug discovery and pharmaceutical industries is gaining access to natural products, including medicinal plants. This bottleneck is heightened for endangered species prohibited for large sample collection, even if they show biological hits. While cultivating the pharmaceutically interesting plant species may be a solution, it is not always possible to grow the organism outside its natural habitat. Plants affected by abiotic stress present a potential alternative source for drug discovery. In order to overcome abiotic environmental stressors, plants may mount a defense response by producing a diversity of PSMs to avoid cells and tissue damage. Plants either synthesize new chemicals or increase the concentration (in most instances) of existing chemicals, including the prominent bioactive lead compounds morphine, camptothecin, catharanthine, epicatechin-3-gallate (EGCG), quercetin, resveratrol, and kaempferol. Most PSMs produced under various abiotic stress conditions are plant defense chemicals and are functionally anti-inflammatory and antioxidative. The major PSM groups are terpenoids, followed by alkaloids and phenolic compounds. We have searched the literature on plants affected by abiotic stress (primarily studied in the simulated growth conditions) and their PSMs (including pharmacological activities) from PubMed, Scopus, MEDLINE Ovid, Google Scholar, Databases, and journal websites. We used search keywords: “stress-affected plants,” “plant secondary metabolites, “abiotic stress,” “climatic influence,” “pharmacological activities,” “bioactive compounds,” “drug discovery,” and “medicinal plants” and retrieved published literature between 1973 to 2021. This review provides an overview of variation in bioactive phytochemical production in plants under various abiotic stress and their potential in the biodiscovery of therapeutic drugs. We excluded studies on the effects of biotic stress on PSMs.
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Secondary metabolite expression in a given plant is a function of biotic, abiotic, and genetic factors that specify species, varieties, and cultivars.
“Indeed, the secondary metabolite expression in a given plant is a function of biotic, abiotic, and genetic factors that specify species, varieties, and cultivars [18].”
From Comprehensive Metabolomic Fingerprinting Combined with Chemometrics Identifies Species- and Variety-Specific Variation of Medicinal Herbs: An Ocimum Study (2023) · cites this paper as [18]
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Flagged first, then by citations
Research works printed but not linked: 2
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Cited by
Sorted by citations
Rizvi, S. A. A., Einstein, G. P., Tulp, O. L., Sainvil, F., & Branly, R. (2022) · Biomolecules · doi:10.3390/biom12101442 · Cited by 181 · see citing works
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- Authors
- Yeshi, K., Crayn, D., Ritmejerytė, E., & Wangchuk, P.
- Affiliations
- Australian Institute of Tropical Health and Medicine (AU)
- Australian Tropical Herbarium (AU)
- Corresponding author
- Yeshi, Karma
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2022-01-05
- Volume
- 27
- Issue
- 1
- Pages
- 313
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC8746929
- OpenAlex
- W4206442306
- Cited by
- 488
- References
- 280
- Citations by year
- 2026: 84 · 2025: 140 · 2024: 142 · 2023: 86 · 2022: 36
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Health and Medical Research Council (APP1183323)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- plant secondary metabolites, abiotic stress, plant defense response, drug discovery, medicinal plants, terpenoids, alkaloids, phenolic compounds, anti-inflammatory activity, antioxidant activity, bioactive phytochemicals, medicinal plant cultivation, threatened plant species
- MeSH terms
- Drug Development, Adaptation, Biological, Biological Products, Climate, Plants, Medicinal, Stress, Physiological, Structure-Activity Relationship, Metabolic Networks and Pathways, Drug Discovery, Phytochemicals, Secondary Metabolism
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