Metabolic Syndrome, Aging and Involvement of Oxidative Stress
Open accessAbstract
The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart diseases. One of the defects in metabolic syndrome and its associated diseases is excess of reactive oxygen species. Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. Such toxic reactions contribute significantly to the aging process. In this article we review current understandings of oxidative stress in metabolic syndrome related disease and its possible contribution to accelerated senescence.
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A high-fat diet is associated with mitochondrial dysfunction, increased levels of oxidative stress and accelerated cellular senescence.
“In contrast, a high-fat diet has been shown to be associated with mitochondrial dysfunction, increased levels of oxidative stress and accelerated cellular senescence [43].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [43]
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- Authors
- Bonomini, F., Rodella, L. F., & Rezzani, R.
- Affiliations
- University of Brescia (IT)
- Venue
- Aging and Disease
- Publisher
- Aging and Disease
- Published
- 2015
- Volume
- 6
- Issue
- 2
- Pages
- 109
- ISSN
- 2152-5250 (ISSN-L)
- PMC
- PMC4365955
- OpenAlex
- W2019486401
- Cited by
- 599
- References
- 142
- Citations by year
- 2026: 19 · 2025: 46 · 2024: 36 · 2023: 61 · 2022: 61 · 2021: 66 · 2020: 55 · 2019: 52 · 2018: 55 · 2017: 61 · 2016: 57 · 2015: 29 · 2014: 1
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Aging and Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- metabolic syndrome, oxidative stress, aging, reactive oxygen species, mitochondrial damage, insulin resistance, obesity, type 2 diabetes, atherosclerosis, vascular inflammation, hypertension, hypertriglyceridemia, accelerated senescence
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