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The macrophage polarization in inflammatory dermatosis and its potential drug candidates

Sun, Qingru, Hu, Shiyu, Lou, Zhaohuan, Gao, Jianli·2023·Biomedicine & Pharmacotherapy
DOI 10.1016/j.biopha.2023.114469
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Abstract

Inflammatory dermatosis is characterized by persistent inflammatory infiltration and hard repair of diseased skin. As a member of the human innate immune cells, macrophages usually show different phenotypes in different diseases. The macrophage phenotype (M1/M2) imbalance caused by the increase of M1 macrophages or the decrease of M2 macrophages is common in inflammatory dermatosis. In recent years, with the deepening research on inflammatory skin diseases, more and more natural medicines/traditional Chinese medicines (TCMs), represented by Shikonin and Angelica Dahurica, have shown their therapeutic effects by affecting the polarization of macrophages. This review introduced macrophage polarization in different inflammatory dermatosis, such as psoriasis. Then summarized the natural medicines/TCMs that have potential therapeutic effects so far and introduced their mechanisms of action and the proteins/signal pathways involved. We found that the TCMs with therapeutic effects listed in this review are closely related to the theory of five flavors and four properties of Chinese medicinal, and most of them are bitter, acrid and sweet. Bitter TCMs have antipyretic, anti-inflammatory and antibacterial effects, which may improve the persistent inflammation of M1 macrophage infiltration. Acrid TCMs have the effect of promoting blood circulation, while sweet TCMs have the effect of nourishing. These 2 flavors may accelerate the repair of skin lesions of inflammatory dermatosis by affe…

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Metadata

Authors
Sun, Q., Hu, S., Lou, Z., & Gao, J.
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2023-05
Volume
161
Pages
114469
ISSN
0753-3322
DOI
10.1016/j.biopha.2023.114469
Cited by
66
References
6
Language
en
Licence
Funders
National Natural Science Foundation of China (82274621)

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