The immunological anatomy of the skin

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

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Obesity is associated with macrophage accumulation in adipose tissue

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The human skin microbiome

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PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

Gordon, S. R., Maute, R. L., Dulken, B. W., Hutter, G., George, B. M., McCracken, M. N., Gupta, R., Tsai, J. M., Sinha, R., Corey, D., et al. (2017) · Nature · doi:10.1038/nature22396 · Cited by 2,247 · see citing works

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

van der Fits, L., Mourits, S., Voerman, J. S. A., Kant, M., Boon, L., Laman, J. D., Cornelissen, F., Mus, A.-M. C., Florencia, E. F., Prens, E. P., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802999 · Cited by 2,202 · see citing works

Skin immune sentinels in health and disease

Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,431 · see citing works

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity

Broz, M. L., Binnewies, M., Boldajipour, B., Nelson, A. E., Pollack, J. L., Erle, D. J., Barczak, A., Rosenblum, M. D., Daud, A., Barber, D. L., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.007 · Cited by 1,207 · see citing works

Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus

Gebhardt, T., Wakim, L. M., Eidsmo, L., Reading, P. C., Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1718 · Cited by 1,157 · see citing works

A diversity profile of the human skin microbiotaPreprint

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Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

Lämmermann, T., Afonso, P. V., Angermann, B., Wang, J. M., Kastenmüller, W., Parent, C. A., & Germain, R. N. (2013) · Nature · doi:10.1038/nature12175 · Cited by 937 · see citing works

Dendritic Cells and Cancer Immunity

Gardner, A., & Ruffell, B. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.006 · Cited by 896 · see citing works

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

SZALLASI, A., Cortright, D. N., Blum, C. A., & Eid, S. R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2280 · Cited by 884 · see citing works

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

Guilliams, M., Dutertre, C., Scott, C. L., McGovern, N. N., Sichien, D., Chakarov, S., Gassen, S. V., Chen, J., Poidinger, M., Prijck, S. D., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.015 · Cited by 824 · see citing works

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

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Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin

Tamoutounour, S., Guilliams, M., Montanana Sanchis, F., Liu, H., Terhorst, D., Malosse, C., Pollet, E., Ardouin, L., Luche, H., Sanchez, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.004 · Cited by 783 · see citing works

Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury

Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z.-R., Hooper, L. V., Schmidt, R. R., von Aulock, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2062 · Cited by 781 · see citing works

Langerhans cells arise from monocytes in vivo

Ginhoux, F., Tacke, F., Angeli, V., Bogunovic, M., Loubeau, M., Dai, X.-M., Stanley, E. R., Randolph, G. J., & Mérad, M. (2006) · Nature Immunology · doi:10.1038/ni1307 · Cited by 741 · see citing works

Plasmacytoid Dendritic Cells (Natural Interferon- α/β-Producing Cells) Accumulate in Cutaneous Lupus Erythematosus Lesions

Farkas, L., Beiske, K., Lund‐Johansen, F., Brandtzæg, P., & Jahnsen, F. L. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61689-6 · Cited by 731 · see citing works

Ectopic lymphoid-like structures in infection, cancer and autoimmunity

Pitzalis, C., Jones, G. W., Bombardieri, M., & Jones, S. A. (2014) · Nature reviews. Immunology · doi:10.1038/nri3700 · Cited by 700 · see citing works

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

Ali, N., Zirak, B., Rodriguez, R. S., Pauli, M. L., Truong, H.-A., Lai, K., Ahn, R., Corbin, K., Lowe, M. M., Scharschmidt, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.002 · Cited by 680 · see citing works

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

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Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

Mackay, L. K., Stock, A. T., Ma, J., Jones, C. M., Kent, S., Mueller, S. N., Heath, W., Carbone, F., & Gebhardt, T. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1202288109 · Cited by 638 · see citing works

Dynamic T cell migration program provides resident memory within intestinal epithelium

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Tertiary lymphoid structures in cancer and beyond

Dieu‐Nosjean, M., Goc, J., Giraldo, N. A., Sautès‐Fridman, C., & Fridman, W. H. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.09.006 · Cited by 616 · see citing works

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

Riol‐Blanco, L., Ordovás-Montañés, J., Perro, M., Naval, E., Thiriot, A., Álvarez, D., Paust, S., Wood, J. N., & von Andrian, U. H. (2014) · Nature · doi:10.1038/nature13199 · Cited by 596 · see citing works

Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence

Wakim, L. M., Davis, A. S. W., & Bevan, M. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010201107 · Cited by 577 · see citing works

Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia

Egawa, N., Egawa, K., Griffin, H. M., & Doorbar, J. (2015) · Viruses · doi:10.3390/v7072802 · Cited by 550 · see citing works

Lung‐resident memory CD8 T cells (TRM) are indispensable for optimal cross‐protection against pulmonary virus infection

Wu, T., Hu, Y., Lee, Y.-T., Bouchard, K. R., Benechet, A. P., Khanna, K., & Cauley, L. S. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313180 · Cited by 537 · see citing works

Early immune events in the induction of allergic contact dermatitis

Kaplan, D. H., Igyártó, B. Z., & Gaspari, A. A. (2012) · Nature reviews. Immunology · doi:10.1038/nri3150 · Cited by 517 · see citing works

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

Kubo, A., Nagao, K., Yokouchi, M., Sasaki, H., & Amagai, M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20091527 · Cited by 491 · see citing works

Dermal adipocytes protect against invasive <i>Staphylococcus aureus</i> skin infection

Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L. (2015) · Science · doi:10.1126/science.1260972 · Cited by 471 · see citing works

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

Linehan, J. L., Harrison, O. J., Han, S.-J., Byrd, A. L., Vujkovic-Cvijin, I., Villarino, A. V., Sen, S. K., Shaik, J., Smelkinson, M., Tamoutounour, S., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.033 · Cited by 456 · see citing works

Nociceptive Sensory Fibers Drive Interleukin-23 Production from CD301b+ Dermal Dendritic Cells and Drive Protective Cutaneous Immunity

Kashem, S. W., Riedl, M. S., Yao, C., Honda, C. N., Vulchanova, L., & Kaplan, D. H. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.016 · Cited by 448 · see citing works

Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases

Wolf, K., Müller, R., Borgmann, S., Bröcker, E., & Friedl, P. (2003) · Blood · doi:10.1182/blood-2002-12-3791 · Cited by 442 · see citing works

T cell migration, search strategies and mechanisms

Krummel, M. F., Bartumeus, F., & Gérard, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.16 · Cited by 423 · see citing works

A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells

Iijima, N., & Iwasaki, A. (2014) · Science · doi:10.1126/science.1257530 · Cited by 420 · see citing works

Immunomorphological and Ultrastructural Characterization of Langerhans Cells and a Novel, Inflammatory Dendritic Epidermal Cell (IDEC) Population in Lesional Skin of Atopic Eczema

Wollenberg, A., Kraft, S., Hanau, D., & Bieber, T. R. M. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12343596 · Cited by 414 · see citing works

Tertiary lymphoid organs in infection and autoimmunity

Neyt, K., Perros, F., GeurtsvanKessel, C. H., Hammad, H., & Lambrecht, B. N. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.04.006 · Cited by 389 · see citing works

Dissecting the formation, structure and barrier function of the stratum corneum

Matsui, T., & Amagai, M. (2015) · International Immunology · doi:10.1093/intimm/dxv013 · Cited by 368 · see citing works

Update of Immune Events in the Murine Contact Hypersensitivity Model: Toward the Understanding of Allergic Contact Dermatitis

Honda, T., Egawa, G., Grabbe, S., & Kabashima, K. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.284 · Cited by 365 · see citing works

Antigen-Presenting Cells in the Skin

Kashem, S. W., Haniffa, M. A., & Kaplan, D. H. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052215 · Cited by 363 · see citing works

Persistence of HIV-1 receptor–positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition

Zhu, J., Hladik, F., Davis, A. S. W., Klock, A. M., Peng, T., Johnston, C., Remington, M. L., Magaret, A., Koelle, D. M., Wald, A., et al. (2009) · Nature Medicine · doi:10.1038/nm.2006 · Cited by 357 · see citing works

Skin-Associated Lymphoid Tissues (SALT): Origins and Functions.

Streilein, J. W. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12536743 · Cited by 339 · see citing works

The influence of skin microorganisms on cutaneous immunity

Belkaid, Y., & Tamoutounour, S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.48 · Cited by 336 · see citing works

Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells

Engelhardt, J., Boldajipour, B. A., Beemiller, P., Pandurangi, P., Sorensen, C. M., Werb, Z., Egeblad, M., & Krummel, M. F. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.008 · Cited by 330 · see citing works

Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

Adachi, T., Kobayashi, T., Sugihara, E., Yamada, T., Ikuta, K., Pittaluga, S., Saya, H., Amagai, M., & Nagao, K. (2015) · Nature Medicine · doi:10.1038/nm.3962 · Cited by 326 · see citing works

Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide

Gao, Y., Lü, C., Su, L., Sharma, A. M., & Lee, R. M. K. W. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707228 · Cited by 323 · see citing works

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin

Nagao, K., Kobayashi, T., Moro, K., Ohyama, M., Adachi, T., Kitashima, D. Y., Ueha, S., Horiuchi, K., Tanizaki, H., Kabashima, K., et al. (2012) · Nature Immunology · doi:10.1038/ni.2353 · Cited by 319 · see citing works

Skin-Associated Lymphoid Tissues (SALT): Origins and Functions

Streilein, J. W. (1983) · Journal of Investigative Dermatology · doi:10.1038/jid.1983.4 · Cited by 318 · see citing works

Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection

Abtin, A., Jain, R., Mitchell, A. J., Roediger, B., Brzoska, A. J., Tikoo, S., Cheng, Q., Ng, L. G., Cavanagh, L. L., von Andrian, U. H., et al. (2013) · Nature Immunology · doi:10.1038/ni.2769 · Cited by 291 · see citing works

Density of DC-LAMP+ mature dendritic cells in combination with activated T lymphocytes infiltrating primary cutaneous melanoma is a strong independent prognostic factor

Ladányi, A., Kiss, J., Somlai, B., Gilde, K., Fejôs, Z., Mohos, A., Gaudi, I., & Tı́már, J. (2007) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-007-0286-3 · Cited by 287 · see citing works

Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice

Tomura, M., Honda, T., Tanizaki, H., Otsuka, A., Egawa, G., TOKURA, Y., Waldmann, H., Hori, S., Cyster, J. G., Watanabe, T., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40926 · Cited by 284 · see citing works

Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march

Egawa, G., & Kabashima, K. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.06.002 · Cited by 265 · see citing works

The Hair Follicle and Immune Privilege

Paus, R., Ito, N., Takigawa, M., & Ito, T. (2003) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2003.00807.x · Cited by 262 · see citing works

Bronchus-Associated Lymphoid Tissue (BALT)

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Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

Colbeck, E. J., Ager, A., Gallimore, A., & Jones, G. W. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01830 · Cited by 252 · see citing works

Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems

Schlitzer, A., McGovern, N. N., & Ginhoux, F. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.03.011 · Cited by 243 · see citing works

Endometrial Histopathology in Patients with Culture-proved Upper Genital Tract Infection and Laparoscopically Diagnosed Acute Salpingitis

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Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues

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Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

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Kimura’s disease: a clinico-pathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia

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Intravital analysis of vascular permeability in mice using two-photon microscopy

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Evaluation of Cutaneous Blood Flow Responses by 133Xenon Washout and a Laser-Doppler Flowmeter

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Imaging of Effector Memory T Cells during a Delayed-Type Hypersensitivity Reaction and Suppression by Kv1.3 Channel Block

Matheu, M. P., Beeton, C., Garcia, A., Chi, V., Rangaraju, S., Safrina, O., Monaghan, K. P., Uemura, M. I., Li, D., Pal, S., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.015 · Cited by 196 · see citing works

High endothelial venules (HEVs) in human melanoma lesions

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Crosstalk between perivascular adipose tissue and blood vessels

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Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

Collins, N., Jiang, X., Zaid, A., Macleod, B. L., Li, J., Park, C. O., Haque, A., Bedoui, S., Heath, W. R., Mueller, S. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11514 · Cited by 187 · see citing works

Langerin neg conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice

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CD1a on Langerhans cells controls inflammatory skin disease

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Sensory TRP channels contribute differentially to skin inflammation and persistent itch

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Induction and functional characterization of class II MHC (Ia) antigens on murine keratinocytes.

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Trogocytosis of peptide–MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils

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The Skin Immune Atlas: Three-Dimensional Analysis of Cutaneous Leukocyte Subsets by Multiphoton Microscopy

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Functional Redundancy of Langerhans Cells and Langerin+ Dermal Dendritic Cells in Contact Hypersensitivity

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Histopathologic Features of Cutaneous Herpes Virus Infections (Herpes Simplex, Herpes Varicella/Zoster)

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Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses

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CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network

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Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells

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Combined Use of Laser Capture Microdissection and cDNA Microarray Analysis Identifies Locally Expressed Disease-Related Genes in Focal Regions of Psoriasis Vulgaris Skin Lesions

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Dermal Clusters of Mature Dendritic Cells and T Cells Are Associated with the CCL20/CCR6 Chemokine System in Chronic Psoriasis

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Hair Follicles from Alopecia Areata Patients Exhibit Alterations in Immune Privilege-Associated Gene Expression in Advance of Hair Loss

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Perivascular Dendritic Macrophages as Immunobiological Constituents of the Human Dermal Microvascular Unit.

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