The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety or depressive disorders
Abstract
Background Previous studies found few abnormalities in hypothalamic-pituitary-adrenal (HPA) axis function in prepubertal children with anxiety or depressive disorders. In this study, we combined data from two independent, consecutive studies to achieve a larger sample size. Our goal was to identify potential alterations in the circadian pattern of cortisol secretion in anxious or depressed children.Methods A total of 124 prepubertal subjects from two independent samples (76 with major depressive disorder, 31 with anxiety disorders, and 17 healthy control subjects) were studied. Blood samples collected for cortisol at hourly intervals over a 24-hour period were examined. Analyses were performed aligning cortisol samples by clock-time. Additional analyses aligning samples by sleep-onset time were performed with a subsample of subjects.Results In the combined sample, significant findings emerged that were previously undetected. Anxious children exhibited significantly lower nighttime cortisol levels and an initially sluggish rise in cortisol during the nighttime when compared with depressed and healthy control children. In contrast, depressed children did not show a clear-cut pattern of differences compared with healthy control children.Conclusions Anxious children seem to exhibit an altered pattern of nighttime cortisol secretion, with an initially sluggish or delayed nocturnal rise before reaching similar peak levels of cortisol near the time of awakening. These findings suggest subtle alterations in HPA axis function in prepubertal children with anxiety disorders.
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“Non-maltreated children with early onset depression rarely display evidence of regulatory dysfunction of the HPA axis”
From The Differential Impacts of Early Physical and Sexual Abuse and Internalizing Problems on Daytime Cortisol Rhythm in School-Aged Children (2010) · cites this paper as Feder, Coplan, Goetz, Mathew, Pine, Dahl, Ryan, Greenwald, & Weissman, 2004
In the citing paper
“because cortisol dysregulation rarely occurs in depressed children who did not experience abuse early in life (Feder et al., 2004)”
From The Differential Impacts of Early Physical and Sexual Abuse and Internalizing Problems on Daytime Cortisol Rhythm in School-Aged Children (2010) · cites this paper as Feder et al., 2004
In the citing paper
“childhood depression without early physical or sexual abuse may be caused by different processes and have different neurobiological features than childhood depression with early abuse.”
From The Differential Impacts of Early Physical and Sexual Abuse and Internalizing Problems on Daytime Cortisol Rhythm in School-Aged Children (2010) · cites this paper as Feder et al., 2004
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Cites
Spitzer, R. L. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770300115013 · Cited by 6,946
Tanner, J. M. (1978) · Medical Entomology and Zoology · Cited by 3,742
Murphy, B. E. P. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-7-973 · Cited by 1,998
Pine, D. S., Cohen, P., Gurley, D., Brook, J., & Ma, Y. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.1.56 · Cited by 1,753
Self-citationThe potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
Heim, C., Ehlert, U., & Hellhammer, D. H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00035-9 · Cited by 1,688
Biological Bases of Childhood Shyness
Kagan, J., Reznick, J. S., & Snidman, N. (1988) · Science · doi:10.1126/science.3353713 · Cited by 1,577
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378
Chambers, W. J., Puig-Antich, J., Hirsch, M., Páez, P., Ambrosini, P., Tabrizi, M., & Davies, M. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790300064008 · Cited by 1,243
Depressed Adolescents Grown Up
Weissman, M. M. (1999) · JAMA · doi:10.1001/jama.281.18.1707 · Cited by 972
Self-citationKELLER, M. B., RYAN, N. D., STROBER, M., KLEIN, R. G., KUTCHER, S. P., BIRMAHER, B., HAGINO, O. R., KOPLEWICZ, H., CARLSON, G. A., CLARKE, G. N., et al. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200107000-00010 · Cited by 641
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Prenatal Anxiety Predicts Individual Differences in Cortisol in Pre-Adolescent Children
O’Connor, T. G., Ben‐Shlomo, Y., Heron, J., Golding, J., Adams, D., & Glover, V. A. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.032 · Cited by 474
Lopez-Duran, N. L., Kovacs, M., & George, C. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.016 · Cited by 425
“…(e.g., Dahl et al., 1992), time of data collection (e.g., Forbes et al., 2006; Mannie et al., 2007), or whether the comparison group consisted of youths with psychiatric diagnoses other than depression (e.g., Casat et al., 1994) or normal controls (e.g., Feder et al., 2004; Forbes et al., 2006).”
BackgroundWalter, H. J., Bukstein, O. G., Abright, A. R., Keable, H., Ramtekkar, U., Ripperger-Suhler, J., & Rockhill, C. (2020) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2020.05.005 · Cited by 335
Cicchetti, D., Rogosch, F. A., Gunnar, M. R., & Toth, S. L. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01393.x · Cited by 337
Measurement and meaning of salivary cortisol: A focus on health and disease in children
Jessop, D. S., & Turner‐Cobb, J. M. (2008) · Stress · doi:10.1080/10253890701365527 · Cited by 284
Metadata
- Authors
- Feder, A., Coplan, J. D., Goetz, R. R., Mathew, S. J., Pine, D. S., Dahl, R. E., Ryan, N. D., Greenwald†, S., & Weissman, M. M.
- Affiliations
- New York State Psychiatric Institute (US)
- State University of New York (US)
- National Institute of Mental Health (US)
- University of Pittsburgh (US)
- Corresponding author
- Feder, Adriana
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 56
- Issue
- 3
- Pages
- 198-204
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2017538352
- Cited by
- 103
- References
- 53
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 6
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH50666)
- National Alliance for Research on Schizophrenia and Depression
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- cortisol secretion, circadian rhythm, hypothalamic-pituitary-adrenal axis, prepubertal children, childhood anxiety disorders, major depressive disorder, sleep latency
- MeSH terms
- Analysis of Variance, Anxiety, Child, Circadian Rhythm, Depressive Disorder, Female, Humans, Hydrocortisone, Male, Radioimmunoassay, Time Factors, Chi-Square Distribution, Area Under Curve
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