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Cited by 103Stress Responses and CortisolChild and Adolescent Psychosocial and Emotional DevelopmentAdrenal Hormones and Disorders

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety or depressive disorders

Feder, Adriana, Coplan, Jeremy D, Goetz, Raymond R, Mathew, Sanjay J, Pine, Daniel S, Dahl, Ronald E, Ryan, Neal D, Greenwald†, Steven, Weissman, Myrna M·2004·Biological Psychiatry
DOI 10.1016/j.biopsych.2004.05.005
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Abstract

Background Previous studies found few abnormalities in hypothalamic-pituitary-adrenal (HPA) axis function in prepubertal children with anxiety or depressive disorders. In this study, we combined data from two independent, consecutive studies to achieve a larger sample size. Our goal was to identify potential alterations in the circadian pattern of cortisol secretion in anxious or depressed children.Methods A total of 124 prepubertal subjects from two independent samples (76 with major depressive disorder, 31 with anxiety disorders, and 17 healthy control subjects) were studied. Blood samples collected for cortisol at hourly intervals over a 24-hour period were examined. Analyses were performed aligning cortisol samples by clock-time. Additional analyses aligning samples by sleep-onset time were performed with a subsample of subjects.Results In the combined sample, significant findings emerged that were previously undetected. Anxious children exhibited significantly lower nighttime cortisol levels and an initially sluggish rise in cortisol during the nighttime when compared with depressed and healthy control children. In contrast, depressed children did not show a clear-cut pattern of differences compared with healthy control children.Conclusions Anxious children seem to exhibit an altered pattern of nighttime cortisol secretion, with an initially sluggish or delayed nocturnal rise before reaching similar peak levels of cortisol near the time of awakening. These findings suggest subtle alterations in HPA axis function in prepubertal children with anxiety disorders.

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Metadata

Authors
Feder, A., Coplan, J. D., Goetz, R. R., Mathew, S. J., Pine, D. S., Dahl, R. E., Ryan, N. D., Greenwald†, S., & Weissman, M. M.
Affiliations
  • New York State Psychiatric Institute (US)
  • State University of New York (US)
  • National Institute of Mental Health (US)
  • University of Pittsburgh (US)
Corresponding author
Feder, Adriana
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2004-08
Volume
56
Issue
3
Pages
198-204
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2004.05.005
OpenAlex
W2017538352
Cited by
103
References
53
Citations by year
2025: 2 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 6
FWCI
1.90
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH50666)
  • National Alliance for Research on Schizophrenia and Depression
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
cortisol secretion, circadian rhythm, hypothalamic-pituitary-adrenal axis, prepubertal children, childhood anxiety disorders, major depressive disorder, sleep latency
MeSH terms
Analysis of Variance, Anxiety, Child, Circadian Rhythm, Depressive Disorder, Female, Humans, Hydrocortisone, Male, Radioimmunoassay, Time Factors, Chi-Square Distribution, Area Under Curve

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