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Cited by 238Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

The DOI matches its Crossref record; 75 of the 80 references it cites were found in a registry or an index.

Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: Association between striatal dopamine markers and motor hyperactivity

Jucaite, Aurelija, Fernell, Elisabeth, Halldin, Christer, Forssberg, Hans, Farde, Lars·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2004.11.009
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Abstract

Background The hypothesis that altered dopamine transmission underlies hyperactive-inattentive behavior in children with attention-deficit/hyperactivity disorder (ADHD) is based on genetic studies and the efficacy of psychostimulants. Most of previous positron emission tomography (PET) and single photon emission tomography (SPET) studies have shown altered binding of dopamine markers in the basal ganglia. Yet, the functional role of the neurochemical disturbances are poorly understood. The purpose of our study was to examine dopamine transporter (DAT) and dopamine D2 receptor (D2R) binding in adolescents with ADHD and to search for its relationship with cognitive functions as well as locomotor hyperactivity.Methods Twelve adolescents with ADHD and 10 young adults were examined with PET using the selective radioligands [11C]PE2I and [11C]raclopride, indexing DAT and D2R density. The simplified reference tissue model was used to calculate binding potential (BP) values. Attention and motor behavior were investigated with a continuous performance task (CPT) and motion measurements.Results The BP value for [11C]PE2I and [11C]raclopride in the striatum of children with ADHD did not differ from that of the young adult control subjects. In the midbrain, however, the BP values for DAT were significantly lower (16%; p = .03) in children with ADHD. Dopamine D2 receptor binding in the right caudate nucleus correlated significantly with increased motor activity (r = .70, p = .01).Conclusions The lower BP values for DAT in the midbrain suggest that dopamine signaling in subjects with ADHD is altered. Altered dopamine signaling might have a causal relationship to motor hyperactivity and might be considered as a potential endophenotype of ADHD.

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Research works printed but not linked: 2

  1. Comings, 1996, Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct and oppositional defiant disorder, J Med Genet, 67, 264
  2. Lou, 2004, ADHD, Dev Med Child Neurol, 46, 179, 10.1111/j.1469-8749.2004.tb00469.x · DOI

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Metadata

Authors
Jucaite, A., Fernell, E., Halldin, C., Forssberg, H., & Farde, L.
Affiliations
Karolinska Institutet (SE)
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-02
Volume
57
Issue
3
Pages
229-238
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2004.11.009
OpenAlex
W1983779361
Cited by
236
References
80
Citations by year
2026: 3 · 2025: 3 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 14 · 2013: 13 · 2012: 21
FWCI
14.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
attention deficit hyperactivity disorder, dopamine transporter, dopamine D2 receptor, midbrain, striatum, caudate nucleus, motor hyperactivity, adolescents, dopamine signaling, endophenotypes, [11C]PE2I, [11C]raclopride, binding potential
MeSH terms
Adolescent, Adult, Age Factors, Attention, Attention Deficit Disorder with Hyperactivity, Brain Mapping, Carbon Isotopes, Child, Corpus Striatum, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Membrane Glycoproteins, Mesencephalon, Motor Activity, Nerve Tissue Proteins, Neuropsychological Tests, Nortropanes, Protein Binding, Radioligand Assay, Time Factors, Tomography, Emission-Computed, Single-Photon, Linear Models, Receptors, Dopamine D2, Dopamine Antagonists, Raclopride, Membrane Transport Proteins, Positron-Emission Tomography, Dopamine Plasma Membrane Transport Proteins

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