CoChat
Sign Up
Cited by 238Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

The DOI matches its Crossref record; 75 of the 80 references it cites were found in a registry or an index.

Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: Association between striatal dopamine markers and motor hyperactivity

Jucaite, Aurelija, Fernell, Elisabeth, Halldin, Christer, Forssberg, Hans, Farde, Lars·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2004.11.009
Open this paper in CoChat — free account

Abstract

Background The hypothesis that altered dopamine transmission underlies hyperactive-inattentive behavior in children with attention-deficit/hyperactivity disorder (ADHD) is based on genetic studies and the efficacy of psychostimulants. Most of previous positron emission tomography (PET) and single photon emission tomography (SPET) studies have shown altered binding of dopamine markers in the basal ganglia. Yet, the functional role of the neurochemical disturbances are poorly understood. The purpose of our study was to examine dopamine transporter (DAT) and dopamine D2 receptor (D2R) binding in adolescents with ADHD and to search for its relationship with cognitive functions as well as locomotor hyperactivity.Methods Twelve adolescents with ADHD and 10 young adults were examined with PET using the selective radioligands [11C]PE2I and [11C]raclopride, indexing DAT and D2R density. The simplified reference tissue model was used to calculate binding potential (BP) values. Attention and motor behavior were investigated with a continuous performance task (CPT) and motion measurements.Results The BP value for [11C]PE2I and [11C]raclopride in the striatum of children with ADHD did not differ from that of the young adult control subjects. In the midbrain, however, the BP values for DAT were significantly lower (16%; p = .03) in children with ADHD. Dopamine D2 receptor binding in the right caudate nucleus correlated significantly with increased motor activity (r = .70, p = .01).Conclusions The lower BP values for DAT in the midbrain suggest that dopamine signaling in subjects with ADHD is altered. Altered dopamine signaling might have a causal relationship to motor hyperactivity and might be considered as a potential endophenotype of ADHD.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2004.11.009

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 2

  1. Comings, 1996, Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct and oppositional defiant disorder, J Med Genet, 67, 264
  2. Lou, 2004, ADHD, Dev Med Child Neurol, 46, 179, 10.1111/j.1469-8749.2004.tb00469.x · DOI

Cited by

Sorted by citations

See all 238

Related

See all

Metadata

Authors
Jucaite, A., Fernell, E., Halldin, C., Forssberg, H., & Farde, L.
Affiliations
Karolinska Institutet (SE)
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-02
Volume
57
Issue
3
Pages
229-238
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2004.11.009
OpenAlex
W1983779361
Cited by
236
References
80
Citations by year
2026: 3 · 2025: 3 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 14 · 2013: 13 · 2012: 21
FWCI
14.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
attention deficit hyperactivity disorder, dopamine transporter, dopamine D2 receptor, midbrain, striatum, caudate nucleus, motor hyperactivity, adolescents, dopamine signaling, endophenotypes, [11C]PE2I, [11C]raclopride, binding potential
MeSH terms
Adolescent, Adult, Age Factors, Attention, Attention Deficit Disorder with Hyperactivity, Brain Mapping, Carbon Isotopes, Child, Corpus Striatum, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Membrane Glycoproteins, Mesencephalon, Motor Activity, Nerve Tissue Proteins, Neuropsychological Tests, Nortropanes, Protein Binding, Radioligand Assay, Time Factors, Tomography, Emission-Computed, Single-Photon, Linear Models, Receptors, Dopamine D2, Dopamine Antagonists, Raclopride, Membrane Transport Proteins, Positron-Emission Tomography, Dopamine Plasma Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review