The DOI matches its Crossref record; 130 of the 134 references it cites were found in a registry or an index.
Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression
Abstract
Background Alzheimer's disease (AD) is clinically characterized by cognitive impairment and behavioral disturbances. The aim of the study was to identify regional alterations in brain function associated with neuropsychiatric symptoms in early AD.Methods Patients underwent measures of cerebral glucose metabolism applying positron emission tomography (PET) and (18)F-fluorodeoxyglucose. Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory (NPI). Positron emission tomography images of patients suffering a neuropsychiatric symptom of clinical significance (NPI subscore for a specific item >/=4 points) were compared with the images of patients without the specific symptom under study (NPI subscore for a specific item = 0 points).Results A total of 53 patients with AD (Mini-Mental State Examination [MMSE] 22.5 +/- 2.94 points) entered the study. Of all symptoms, apathy and depression were most frequently encountered. The patient group with apathy (n = 17) revealed significant decreases in left orbitofrontal regions when compared with patients free of apathy. Depression of clinical significance (n = 10) was associated with hypometabolism in dorsolateral prefrontal regions.Conclusions These findings support the notion that different functional circuits underlie apathy and depression in early AD.
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“Apathy is further associated with greater amyloid burden in bilateral frontal cortex (Mori et al., 2014), reduced orbitofrontal metabolism on the left (Holthoff et al., 2005) or right (Lanctôt et al., 2007), and reduced connectivity in left-sided functional connectivity with frontal cortex (Baggio et al., 2015).”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Holthoff et al., 2005
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Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
Rosenberg, P. B., Nowrangi, M. A., & Lyketsos, C. G. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.05.005 · Cited by 302
Chen, Y., Dang, M., & Zhang, Z. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00456-1 · Cited by 238
Metadata
- Authors
- Holthoff, V. A., Beuthien-Baumann, B., Kalbe, E., Lüdecke, S., Lenz, O., Zündorf, G., Spirling, S., Schierz, K., Winiecki, P., Sorbi, S., & Herholz, K.
- Affiliations
- Max Planck Society (DE)
- Technische Universität Dresden (DE)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 57
- Issue
- 4
- Pages
- 412-421
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2141448905
- Cited by
- 190
- References
- 134
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 15 · 2019: 6 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 11 · 2012: 12
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- Alzheimer's disease, early Alzheimer's disease, regional cerebral glucose metabolism, apathy, depression, neuropsychiatric symptoms, orbitofrontal cortex, dorsolateral prefrontal cortex, hypometabolism
- MeSH terms
- Aged, Alzheimer Disease, Brain Mapping, Cerebral Cortex, Cerebrovascular Circulation, Demography, Depression, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Mood Disorders, Positron-Emission Tomography, Leukoaraiosis
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