Cited by 190Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsFunctional Brain Connectivity Studies

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Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression

Holthoff, Vjera A., Beuthien-Baumann, Bettina, Kalbe, Elke, Lüdecke, Susanne, Lenz, Olaf, Zündorf, Gerhard, Spirling, Sebastian, Schierz, Kristin, Winiecki, Peter, Sorbi, Sandro, Herholz, Karl·2005·Biological Psychiatry

DOI 10.1016/j.biopsych.2004.11.035

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Abstract

Background Alzheimer's disease (AD) is clinically characterized by cognitive impairment and behavioral disturbances. The aim of the study was to identify regional alterations in brain function associated with neuropsychiatric symptoms in early AD.Methods Patients underwent measures of cerebral glucose metabolism applying positron emission tomography (PET) and (18)F-fluorodeoxyglucose. Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory (NPI). Positron emission tomography images of patients suffering a neuropsychiatric symptom of clinical significance (NPI subscore for a specific item >/=4 points) were compared with the images of patients without the specific symptom under study (NPI subscore for a specific item = 0 points).Results A total of 53 patients with AD (Mini-Mental State Examination [MMSE] 22.5 +/- 2.94 points) entered the study. Of all symptoms, apathy and depression were most frequently encountered. The patient group with apathy (n = 17) revealed significant decreases in left orbitofrontal regions when compared with patients free of apathy. Depression of clinical significance (n = 10) was associated with hypometabolism in dorsolateral prefrontal regions.Conclusions These findings support the notion that different functional circuits underlie apathy and depression in early AD.

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Authors: Holthoff, V. A., Beuthien-Baumann, B., Kalbe, E., Lüdecke, S., Lenz, O., Zündorf, G., Spirling, S., Schierz, K., Winiecki, P., Sorbi, S., & Herholz, K.
Affiliations: Max Planck Society (DE)
Technische Universität Dresden (DE)
ORCID: Kalbe, Elke
Sorbi, Sandro
Herholz, Karl
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2005-02
Volume: 57
Issue: 4
Pages: 412-421
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2004.11.035
OpenAlex: W2141448905
Cited by: 190
References: 134
Citations by year: 2026: 2 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 15 · 2019: 6 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 11 · 2012: 12
FWCI: 5.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Florence Research (University of Florence) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: Alzheimer's disease, early Alzheimer's disease, regional cerebral glucose metabolism, apathy, depression, neuropsychiatric symptoms, orbitofrontal cortex, dorsolateral prefrontal cortex, hypometabolism
MeSH terms: Aged, Alzheimer Disease, Brain Mapping, Cerebral Cortex, Cerebrovascular Circulation, Demography, Depression, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Mood Disorders, Positron-Emission Tomography, Leukoaraiosis

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Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression

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