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Cited by 190Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsFunctional Brain Connectivity Studies

The DOI matches its Crossref record; 130 of the 134 references it cites were found in a registry or an index.

Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression

Holthoff, Vjera A., Beuthien-Baumann, Bettina, Kalbe, Elke, Lüdecke, Susanne, Lenz, Olaf, Zündorf, Gerhard, Spirling, Sebastian, Schierz, Kristin, Winiecki, Peter, Sorbi, Sandro, Herholz, Karl·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2004.11.035
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Abstract

Background Alzheimer's disease (AD) is clinically characterized by cognitive impairment and behavioral disturbances. The aim of the study was to identify regional alterations in brain function associated with neuropsychiatric symptoms in early AD.Methods Patients underwent measures of cerebral glucose metabolism applying positron emission tomography (PET) and (18)F-fluorodeoxyglucose. Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory (NPI). Positron emission tomography images of patients suffering a neuropsychiatric symptom of clinical significance (NPI subscore for a specific item >/=4 points) were compared with the images of patients without the specific symptom under study (NPI subscore for a specific item = 0 points).Results A total of 53 patients with AD (Mini-Mental State Examination [MMSE] 22.5 +/- 2.94 points) entered the study. Of all symptoms, apathy and depression were most frequently encountered. The patient group with apathy (n = 17) revealed significant decreases in left orbitofrontal regions when compared with patients free of apathy. Depression of clinical significance (n = 10) was associated with hypometabolism in dorsolateral prefrontal regions.Conclusions These findings support the notion that different functional circuits underlie apathy and depression in early AD.

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Crossref · 10.1016/j.biopsych.2004.11.035

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Cites

Research works printed but not linked: 3

  1. Cummings, 1999, Progress in the management of behavioral symptoms in Alzheimer’s disease, Alzheimer Insights, 5, 1
  2. Finkel, 1996, Behavioral and psychological signs and symptoms of dementia, Int Psychogeriatr, 8, 497
  3. Whitehouse, 1997, Quality-of-life assessment in dementia drug development, Alzheimer Dis Assoc Disord, 11, 56

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Metadata

Authors
Holthoff, V. A., Beuthien-Baumann, B., Kalbe, E., Lüdecke, S., Lenz, O., Zündorf, G., Spirling, S., Schierz, K., Winiecki, P., Sorbi, S., & Herholz, K.
Affiliations
  • Max Planck Society (DE)
  • Technische Universität Dresden (DE)
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-02
Volume
57
Issue
4
Pages
412-421
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2004.11.035
OpenAlex
W2141448905
Cited by
190
References
134
Citations by year
2026: 2 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 15 · 2019: 6 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 11 · 2012: 12
FWCI
5.60
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
Alzheimer's disease, early Alzheimer's disease, regional cerebral glucose metabolism, apathy, depression, neuropsychiatric symptoms, orbitofrontal cortex, dorsolateral prefrontal cortex, hypometabolism
MeSH terms
Aged, Alzheimer Disease, Brain Mapping, Cerebral Cortex, Cerebrovascular Circulation, Demography, Depression, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Mood Disorders, Positron-Emission Tomography, Leukoaraiosis

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